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NEJM:甲状腺相关性并发症-案例报道

2016-07-21 chenshuo 译 MedSci原创

男性患者,56岁,近日因甲状腺相关性皮肤问题到院就诊。据该患者称,在3年前他曾被诊断患有甲状腺相关眼病和皮肤病。当时接受了放射性碘消融术进行治疗。

男性患者,56岁,近日因甲状腺相关性皮肤问题到院就诊。

 
据该患者称,在3年前他曾被诊断患有甲状腺相关眼病和皮肤病。当时接受了放射性碘消融术进行治疗。

经治疗1年后,其开始出现眼球突出和胫前粘液性水肿症状(如图A和B所示)。之后该患者又接受了眼眶减压术。 

在这次就诊中,体格检查发现其小腿部和脚部的皮肤病变越发严重,类似于橡皮肿样(如图C)。此外,其双手相对于以前显得更加的粗大,双手手指像棍棒形(如图D)。

手掌部X光拍片检查显示多指骨和掌骨骨膜炎(如图E,箭头),另外还有软组织弥漫性肿胀,与甲状腺毒症的变化一致,这与Graves病的罕见表现类似。

实验室检查结果表明,促甲状腺素受体抗体水平>40 IU/L(正常范围,≤1.75 IU/L)。

最后,该患者接受静脉注射免疫球蛋白和利妥昔单抗药物联合治疗。在接下来的几个月随访中,发现该患者的症状得到了很好地控制。 

原始出处:

Carlo Guerrero, M.D.Mark R. Pittelkow, M.D.Thyroid Ophthalmopathy, Dermopathy, and AcropachyN Engl J Med .July 21, 2016

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    2016-08-15 丁鹏鹏
  3. [GetPortalCommentsPageByObjectIdResponse(id=1837193, encodeId=5078183e19352, content=<a href='/topic/show?id=3f34e253206' target=_blank style='color:#2F92EE;'>#相关性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72532, encryptionId=3f34e253206, topicName=相关性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=shenxlcyp, createdTime=Tue Feb 28 17:08:00 CST 2017, time=2017-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1757723, encodeId=c3371e5772363, content=<a href='/topic/show?id=84ba49031f9' target=_blank style='color:#2F92EE;'>#并发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=49031, encryptionId=84ba49031f9, topicName=并发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a27e37327108, createdName=丁鹏鹏, createdTime=Mon Aug 15 14:08:00 CST 2016, time=2016-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=142685, encodeId=48e0142685e7, content=文章很好,继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Sun Oct 09 15:56:19 CST 2016, time=2016-10-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=131799, encodeId=e071131e997d, content=文章很好,非常有益, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Tue Sep 20 22:38:00 CST 2016, time=2016-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128466, encodeId=1d3b1284669a, content=不错哦,会学到很多, beContent=null, objectType=article, channel=null, level=null, likeNumber=79, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 16 09:25:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=125623, encodeId=e8ce12562385, content=学习新知识了,感谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160907/IMG57D00CF1965701770.jpg, createdBy=565c1948251, createdName=舒心和人, createdTime=Tue Sep 13 18:43:00 CST 2016, time=2016-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=111613, encodeId=dfb71116131f, content=很好,不错,以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Mon Sep 05 16:50:00 CST 2016, time=2016-09-05, status=1, ipAttribution=)]
    2016-10-09 1e10c84am36(暂无匿称)

    文章很好,继续关注

    0

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    2016-09-20 1e10c84am36(暂无匿称)

    文章很好,非常有益

    0

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    2016-09-16 1e10c84am36(暂无匿称)

    不错哦,会学到很多

    0

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    2016-09-13 舒心和人

    学习新知识了,感谢分享

    0

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    2016-09-05 李东泽

    很好,不错,以后会多学习

    0

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