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CLIN CANCER RES：利用放射性标记转铁蛋白无创检测mTORC1信号

2017-07-03 MedSci MedSci原创

mTORC1转铁蛋白放射性标记
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mTOR调节许多正常的生理过程，当其活性过高时可以导致多种肿瘤及疾病的发生。在动物模型及人体中无创检测mTOR信号难度很大。CLIN CANCER RES近期发表了一篇文章，研究利用核显像工具检测细胞内mTOR活性。

mTOR调节许多正常的生理过程，当其活性过高时可以导致多种肿瘤及疾病的发生。在动物模型及人体中无创检测mTOR信号难度很大。CLIN CANCER RES近期发表了一篇文章，研究利用核显像工具检测细胞内mTOR活性。

使用核显像不能直接的测量mTOR生化活性，但是可以利用转铁蛋白受体间接测量细胞内mTOR活性改变。在经过体外实验验证活化mTORC1可以刺激放射性标记的转铁蛋白摄取后，作者发现在老鼠正常及肿瘤组织中通过利用PET可以通过89Zr标记的转铁蛋白测量mTORC1信号强度。作者还发现89Zr标记的转铁蛋白可以检测到抗激素标准治疗时肿瘤细胞逃逸抗肿瘤作用的mTORC1上调，这是第一次有人使用PET识别治疗抵抗的肿瘤。

文章最后认为，作者开创性地使用核显像工具在体外、正常组织、以及动物模型中检测mTOR信号变化。这项技术可以后续在人体中进行应用。

原始出处：
Charles Truillet,John T.Cunningham,et al.Noninvasive Measurement of mTORC1 Signaling with 89Zr-Transferrin.CLIN CANCER RES.June 2017 doi:10.1158/1078-0432.CCR-16-2448

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    2017-07-05 雕雕

    #mTORC1#

    0

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    2017-07-05 bnurmamat

    #转铁蛋白#

    0

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    2017-07-05 zhangpaul93

    #无创检测#

    0

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    2017-07-05 zhangpaul93

    #无创检测#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1418391, encodeId=e4ac14183910d, content=<a href='/topic/show?id=2cc91232947' target=_blank style='color:#2F92EE;'>#mTORC1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12329, encryptionId=2cc91232947, topicName=mTORC1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59413348493, createdName=雕雕, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553423, encodeId=a70d15534231e, content=<a href='/topic/show?id=3c21934e7a7' target=_blank style='color:#2F92EE;'>#转铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93477, encryptionId=3c21934e7a7, topicName=转铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=053d14374839, createdName=bnurmamat, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559853, encodeId=f7ed155985365, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565862, encodeId=f0721565862b1, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218389, encodeId=dae121838997, content=好好的学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Jul 04 07:45:26 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218304, encodeId=0e0c218304c9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Tue Jul 04 00:21:48 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218275, encodeId=29762182e5e8, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:57:53 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218215, encodeId=3d1e21821536, content=受益匪浅，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 03 20:13:42 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 忠诚向上

    好好的学习一下

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1418391, encodeId=e4ac14183910d, content=<a href='/topic/show?id=2cc91232947' target=_blank style='color:#2F92EE;'>#mTORC1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12329, encryptionId=2cc91232947, topicName=mTORC1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59413348493, createdName=雕雕, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553423, encodeId=a70d15534231e, content=<a href='/topic/show?id=3c21934e7a7' target=_blank style='color:#2F92EE;'>#转铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93477, encryptionId=3c21934e7a7, topicName=转铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=053d14374839, createdName=bnurmamat, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559853, encodeId=f7ed155985365, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565862, encodeId=f0721565862b1, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218389, encodeId=dae121838997, content=好好的学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Jul 04 07:45:26 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218304, encodeId=0e0c218304c9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Tue Jul 04 00:21:48 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218275, encodeId=29762182e5e8, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:57:53 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218215, encodeId=3d1e21821536, content=受益匪浅，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 03 20:13:42 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-04 189****7206

    学习了谢谢分享

    0

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    2017-07-03 luominglian113

    学习了，谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1418391, encodeId=e4ac14183910d, content=<a href='/topic/show?id=2cc91232947' target=_blank style='color:#2F92EE;'>#mTORC1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12329, encryptionId=2cc91232947, topicName=mTORC1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=59413348493, createdName=雕雕, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553423, encodeId=a70d15534231e, content=<a href='/topic/show?id=3c21934e7a7' target=_blank style='color:#2F92EE;'>#转铁蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93477, encryptionId=3c21934e7a7, topicName=转铁蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=053d14374839, createdName=bnurmamat, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1559853, encodeId=f7ed155985365, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1565862, encodeId=f0721565862b1, content=<a href='/topic/show?id=edd15889ed4' target=_blank style='color:#2F92EE;'>#无创检测#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58897, encryptionId=edd15889ed4, topicName=无创检测)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a9de34, createdName=zhangpaul93, createdTime=Wed Jul 05 09:12:00 CST 2017, time=2017-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218389, encodeId=dae121838997, content=好好的学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Tue Jul 04 07:45:26 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218304, encodeId=0e0c218304c9, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5Kzuf9u71gZhPYMiajRtENwicoAABeQtfXOlic8ibhYSy6DvJZWUDVtjRvTfqBffr1XJ6JLtFB5kHicthl/0, createdBy=08bb2061153, createdName=189****7206, createdTime=Tue Jul 04 00:21:48 CST 2017, time=2017-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218275, encodeId=29762182e5e8, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Jul 03 23:57:53 CST 2017, time=2017-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=218215, encodeId=3d1e21821536, content=受益匪浅，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon Jul 03 20:13:42 CST 2017, time=2017-07-03, status=1, ipAttribution=)]
    2017-07-03 清风拂面

    受益匪浅，谢谢分享

    0

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