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JACC:在老年人中,理想的心血管健康指标与成人全因死亡率和血管事件的关系

2017-06-20 MedSci MedSci原创

在中年患者中,理想心血管健康(CVH)对健康相关结果的好处是确定的。但随着老年人口不断增长,慢性疾病的高发病率和药物治疗可能会抵消这种益处。

背景:在中年患者中,理想心血管健康(CVH)对健康相关结果的好处是确定的。但随着老年人口不断增长,慢性疾病的高发病率和药物治疗可能会抵消这种益处。

目的:在社区中老年人群中,探讨理想心血管健康指标与死亡率、冠心病及中风事件的相关性并进行分析。

方法:从1999年到2001年,分别对来自3个城市的65岁及以上的9294名(男性和女性)患者进行了检测,并在此基础上对研究中发生的血管事件和死亡率进行了随访。通过Cox比例风险模型估计危险比(HRs),并将3到4个和5到7个理想指标的受试者分别与0到2个理想指标进行比较。

结果:平均年龄为73.8±5.3年,36.7%都是男性。只有5%的参与有5以上的指标在理想水平。在随访10.9年和8.6年后,分别发生了1,987例死亡和680例冠心病或中风事件。经多元分析,理想指标的类别中死亡率和血管事件的风险降低。特别是与理想指标≤2的受试者相比,理想指标≥5的受试者的全因死亡率降低了29%(危险比[HR]:0.71;95%可信区间[CI]:0.55 ~0.90),冠心病和中风共降低了67%(危险比:0.33;95%置信区间:0.19 ~0.57)(p < 0.001)。

结论:即使在老年人中,较高的健康指标对死亡率和血管事件风险有很大的益处。

原始出处
Bamba Gaye, Marianne Canonico, Marie-Cécile Perier,et al. Ideal Cardiovascular Health, Mortality, and Vascular Events in Elderly Subjects. JACC. 2017 June.

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    2018-02-08 hbwxf
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