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Stroke:空气污染物的短期暴露与心源性脑卒中相关

2016-12-25 haofan MedSci原创

该研究结果表明,空气污染物的短期暴露与心源性脑卒中相关,在污染达到高峰时期,更应注意那些易患脑栓塞的个体。减少空气污染的公共和环境健康政策可以帮助减缓心源性脑卒中的全球增长趋势。

近日,卒中领域权威杂志Stroke上发表了一篇研究文章,旨在评估短期暴露于空气污染对缺血性脑卒中亚型的影响,并且重点评估了空气污染对心源性栓塞引起的脑卒中的影响。

该研究的数据来自一个全国性的、多中心、前瞻性卒中登记数据库,在这个研究中共有12个医疗中心其中纳入了13,535例急性缺血性脑卒中住院患者。研究人员从全国181个空气污染监测站收集了小于10μM的颗粒物、二氧化氮(NO2)、二氧化硫(SO2)、臭氧(O3)、一氧化碳(CO)的小时浓度数据。在脑卒中发病前7天从距患者最近的空气质量监测站获得的这些空气污染物的平均值用来评估脑卒中亚型的相关性。该研究的主要终点为脑卒中的亚型,包括大血管病变、小血管闭塞、心源性脑栓塞,以及其他不明原因的脑卒中。

研究人员发现与大动脉粥样硬化和非心源性脑卒中相比,小于10μM的颗粒物和SO2浓度与心源性脑卒中的风险增加独立相关。在分层分析中,心源性脑卒中患者的比例与小于10μm的颗粒物、NO2和SO2的五分位数呈正相关。此外,季节和地理因素与心源性脑卒中的比例增加也有关,这可能是由于高水平的空气污染所致。

该研究结果表明,空气污染物的短期暴露与心源性脑卒中相关,在污染达到高峰时期,更应注意那些易患脑栓塞的个体。减少空气污染的公共和环境健康政策可以帮助减缓心源性脑卒中的全球增长趋势。  

原始出处:

Jong-Won Chung, et al. Air Pollution Is Associated With Ischemic Stroke via Cardiogenic Embolism. Stroke.  2016.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

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    2016-12-27 mhm295
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    2016-12-26 Lisa971

    暴露因素的研究,属于队列研究。

    0

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