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CELL METAB:糖尿病前期和糖尿病中的肠道微生物群:一项基于人群的交叉剖面研究 

2020-07-12 MedSci原创 MedSci原创

肠道微生物群和2型糖尿病(T2D)之间的联系值得进一步调查,因为已有的研究显示了肠道微生物群抗糖尿病治疗的混杂效应。

肠道微生物群和2型糖尿病(T2D)之间的联系值得进一步调查,因为已有的研究显示了肠道微生物群抗糖尿病治疗的混杂效应。

最近,研究人员对一个发现(n = 1,011)和验证(n = 484)队列中的肠道微生物群进行了剖析,该队列由未接受糖尿病治疗的瑞典受试者组成,受试者按血糖状态分组。

研究人员观察到,在糖耐量受损、合并葡萄糖不耐受和T2D的群体中,整体肠道微生物群组成发生了改变,但在空腹血糖受损的群体中没有改变。

此外,在糖尿病前期和T2D组中,几种丁酸盐生产者的丰度和生产丁酸盐的潜能均有所下降。

多变量分析和机器学习的微生物组模型表明,胰岛素抵抗与微生物变化密切相关。

因此,该研究表明,在开发预防和/或延缓T2D的精准医学方法时,肠道微生物群代表了一个重要的可调节因素。

 

原始出处:

Hao Wu et al. The Gut Microbiota in Prediabetes and Diabetes: A Population-Based Cross-Sectional Study, Cell Metabolism (2020). DOI:https://doi.org/10.1016/j.cmet.2020.06.011

 

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  6. 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  8. 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objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 12 13:55:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802585, encodeId=f4e4802585c6, content=交叉剖面?是横断面,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82110268, createdName=tiancaiwxb, createdTime=Sun Jul 12 11:40:35 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802578, encodeId=f61f8025e8b4, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 12 10:57:28 CST 2020, time=2020-07-12, status=1, ipAttribution=)]
    2020-07-12 misszhang

    谢谢MedSci提供最新的资讯

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1896695, encodeId=44181896695b8, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Sat Apr 17 00:55:28 CST 2021, time=2021-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888168, encodeId=2588188816887, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, 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topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Mon Oct 12 08:55:28 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1825172, encodeId=f4e918251e20a, content=<a href='/topic/show?id=702a5065860' target=_blank style='color:#2F92EE;'>#微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50658, encryptionId=702a5065860, topicName=微生物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Tue Mar 16 20:55:28 CST 2021, time=2021-03-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1298862, encodeId=49551298862b7, content=<a href='/topic/show?id=2088816e487' target=_blank style='color:#2F92EE;'>#肠道微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81674, encryptionId=2088816e487, topicName=肠道微生物群)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6e43278, createdName=yangjxjc, createdTime=Tue Jul 14 01:55:28 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1367810, encodeId=feb3136e81071, content=<a href='/topic/show?id=2cee50e22c6' target=_blank style='color:#2F92EE;'>#微生物群#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50722, encryptionId=2cee50e22c6, topicName=微生物群)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Tue Jul 14 01:55:28 CST 2020, time=2020-07-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1043216, encodeId=20d31043216c4, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jul 12 13:55:28 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802585, encodeId=f4e4802585c6, content=交叉剖面?是横断面,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5c82110268, createdName=tiancaiwxb, createdTime=Sun Jul 12 11:40:35 CST 2020, time=2020-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=802578, encodeId=f61f8025e8b4, content=<a href='/topic/show?id=b1fd816e094' target=_blank style='color:#2F92EE;'>#肠道微生物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=149, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81670, encryptionId=b1fd816e094, topicName=肠道微生物)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Sun Jul 12 10:57:28 CST 2020, time=2020-07-12, status=1, ipAttribution=)]
    2020-07-12 tiancaiwxb

    交叉剖面?是横断面,谢谢

    0

  10. 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