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Neurology:海绵状血管畸形出血风险分析!

2018-02-03 xing.T MedSci原创

由此可见,年龄小(<45岁)、幕下位置和存在DVA与较高的出血风险相关。CM体积(≥1cm3)和存在DVA分别按照解剖位置是CM破裂的高风险因素。

尽管有海绵状血管畸形(CM)出血相关的年度风险较低(每年0.6%-1.1%),但是再出血率和神经功能缺损的严重程度风险明显较高;近日,神经病学领域权威取杂志Neurology上发表了一篇研究文章,研究人员旨在评估CMs的破裂风险,取决于各种因素。

研究人员回顾性地分析所在机构1999年至2016年4月收治的CM患者的病历资料,并对海绵状血管瘤的体积、病灶的位置、有无发育性静脉异常(DVA)、海绵状血管瘤数量与患者特征(性别、年龄、高血压和抗栓治疗)进行评估。

一百五十四例CM患者被纳入分析,89例(58%)CM破裂患者。在统计的单变量分析中,CM破裂组患者DVA存在明显高于对照组(P<0.001,比值比[OR]为4.6)。包含所有的独立危险因素的多变量分析指定年轻(<45岁)(P<0.05;OR为2.2)、幕下位置(P<0.01;OR为2.9)和DVA的存在(P<0.0001;OR为4.7)的患者破裂风险明显增高。对这些解剖位置进行单独分析,幕上和幕下,表明幕上破裂的病例存在DVA(P<0.01;OR为4.16)和幕下破裂的病例CM体积(≥1cm3)(P<0.0001;OR为3.5)是出血的独立预测因素。

由此可见,年龄小(<45岁)、幕下位置和存在DVA与较高的出血风险相关。CM体积(≥1cm3)和存在DVA分别按照解剖位置是CM破裂的高风险因素。

原始出处:

Sepide Kashefiolasl,et al. A benchmark approach to hemorrhage risk management of cavernous malformations.Neurology. 2018. https://doi.org/10.1212/WNL.0000000000005066

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    2018-11-25 yinhl1978
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    2018-02-05 cooco
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    2018-02-03 虈亣靌

    学习了很有用不错

    0

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