Baidu
map

Blood:磷脂酰肌醇转运蛋白参与调控巨核细胞TGF-β1分泌和造血作用

2018-07-25 MedSci MedSci原创

中心点:磷脂酰肌醇转运蛋白(Pitps)可刺激巨核细胞分泌TGF-β1,进而调控造血。Pitpα-/-·β-/-巨核细胞的α颗粒的形态和功能均存在缺陷。摘要:Maegan Capitano等人推测磷脂酰肌醇转运蛋白(Pitp)介导的巨核细胞(MK)磷酸肌醇信号参与造血干细胞(HSC)和造血祖细胞(HPC)调控,故建立特异性敲除MKs和血小板的Pitps的小鼠模型(pitpα-/-和pitpα-/-

中心点:

磷脂酰肌醇转运蛋白(Pitps)可刺激巨核细胞分泌TGF-β1,进而调控造血。

Pitpα-/-·β-/-巨核细胞的α颗粒的形态和功能均存在缺陷。

摘要:

Maegan Capitano等人推测磷脂酰肌醇转运蛋白(Pitp)介导的巨核细胞(MK)磷酸肌醇信号参与造血干细胞(HSC)和造血祖细胞(HPC)调控,故建立特异性敲除MKs和血小板的Pitps的小鼠模型(pitpα-/-和pitpα-/-·β-/-),对此开展研究。

pitpα-/-和pitpα-/-·β-/-小鼠骨髓(BM)中的HSC、巨核系-红系祖细胞和HPC数量均减少。竞争性移植和限制性稀释分析显示pitpα-/-·β-/-BM的移植能力明显降低。与WT BM MK相比,培养pitpα-/-和pitpα-/-·β-/-BM MKs的培养基(CM)中含有更高水平的转化生长因子β1(TGF-β1)和白介素(IL)-4。pitpα-/-和pitpα-/-·β-/-MKs的CM可显着抑制HPC的克隆形成;在体外,该抑制作用可被中和性抗TGF-β抗体完全抵消;抗TGF-β抗体治疗pitpα-/-·β-/-小鼠也可完全逆转其BM HSC和HPC数量缺陷。在体外,TGF-β和IL-4可协同抑制HPC克隆形成。pitpα-/-·β-/-MKs的电子显微镜分析其超微结构发现α颗粒缺乏,还存在大的畸形的多囊体。血管性血友病因子和血小板反应蛋白,类似于TGF-β,均储存于MKs的α颗粒,在培养pitpα-/-·β-/-MKs的CM中也表现为增高。

总而言之,敲除MKs的Pitps可通过扰乱α颗粒的正常生理、破坏TGF-β分泌间接影响造血作用。

原始出处:

Maegan Capitano,et al. Phosphatidylinositol transfer proteins regulate megakaryocyte TGF-β1 secretion and hematopoiesis in mice. Blood  2018  :blood-2017-09-806257;  doi: https://doi.org/10.1182/blood-2017-09-806257 

本文系梅斯医学(MedSci)原创编译,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2019-06-28 yzh409
  3. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2019-06-29 changhe713
  4. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2018-08-15 gwc392
  5. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2011134, encodeId=6feb2011134fc, content=<a href='/topic/show?id=0a351e34776' target=_blank style='color:#2F92EE;'>#TGF-β1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17347, encryptionId=0a351e34776, topicName=TGF-β1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f634250, createdName=chentianping, createdTime=Thu Nov 01 15:31:00 CST 2018, time=2018-11-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696314, encodeId=2e0016963145a, content=<a href='/topic/show?id=0107934e0a5' target=_blank style='color:#2F92EE;'>#转运#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=116, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93470, encryptionId=0107934e0a5, topicName=转运)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47c429881595, createdName=yzh409, createdTime=Fri Jun 28 11:31:00 CST 2019, time=2019-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2035874, encodeId=a55e20358e478, content=<a href='/topic/show?id=575c1e341a8' target=_blank style='color:#2F92EE;'>#TGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17341, encryptionId=575c1e341a8, topicName=TGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=56ea361, createdName=changhe713, createdTime=Sat Jun 29 22:31:00 CST 2019, time=2019-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682449, encodeId=19781682449ff, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Wed Aug 15 15:31:00 CST 2018, time=2018-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1801434, encodeId=8792180143413, content=<a href='/topic/show?id=0b9ee38391d' target=_blank style='color:#2F92EE;'>#磷脂酰肌醇转运蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73839, encryptionId=0b9ee38391d, topicName=磷脂酰肌醇转运蛋白)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jan 14 07:31:00 CST 2019, time=2019-01-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1441365, encodeId=dc18144136584, content=<a href='/topic/show?id=58dd1e34591' target=_blank style='color:#2F92EE;'>#TGF-β#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17345, encryptionId=58dd1e34591, topicName=TGF-β)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=496f4824495, createdName=ms6980045490879608, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1490274, encodeId=ff5a14902e4c6, content=<a href='/topic/show?id=af9f48201a9' target=_blank style='color:#2F92EE;'>#巨核细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=48201, encryptionId=af9f48201a9, topicName=巨核细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f3d78715376, createdName=liuquan, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1494634, encodeId=57bf149463490, content=<a href='/topic/show?id=084d9499599' target=_blank style='color:#2F92EE;'>#造血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=94995, encryptionId=084d9499599, topicName=造血)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=caed9138962, createdName=俅侠, createdTime=Fri Jul 27 06:31:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2018-07-27 俅侠

相关资讯

Blood:北京基因组所揭示新靶点NOTCH4在人巨核细胞发育和再生中的重要作用

近日,中国科学院北京基因组研究所精准基因组医学重点实验室王前飞研究组与美国约翰霍普金斯大学医学院程临钊教授合作,揭示了NOTCH4作为转录因子RUNX1的靶基因调控体外巨核细胞发育,并筛选出可促进体外巨核细胞再生的小分子抑制剂。该研究不仅找到了体外巨核细胞再生的新靶点,并且提供了一种利用罕见病寻找再生靶点的新思路,相关成果受邀在第58届美国血液学年会上做口头报告,并获得该年会的摘要成就奖,论文发表

Blood:ADAP缺陷可影响巨核细胞极化、促进血小板前体异位释放,从而导致微血小板减少症

中心点:小鼠ADAP缺陷可导致血小板寿命缩短和异位释放,进而导致微血小板减少。巨核细胞缺乏ADAP会损坏DMS极化和伪足小体形成。摘要:骨髓巨核细胞(MKs)通过将血小板前体延伸到窦状血管产生血小板。血小板生成缺陷可导致血小板减少症,增加出血倾向。近期,有报道称先天性常染色体隐性小血小板减少症(CARST)是由ADAP(黏附和脱颗粒促进调节蛋白,又名FYB、SLAP130/120)基因突变导致的,

先天性巨核细胞增生不良性血小板减少症的研究进展

先天性巨核细胞增生不良性血小板减少症(CAMT)是一种罕见的遗传性骨髓衰竭综合征,表现为严重的血小板减少、骨髓巨核细胞减少或缺如,不伴有特异性躯体畸形,最终发展为再生障碍性贫血或继发性骨髓恶性肿瘤。在早期报道中,由于无法及时进行血小板输注及造血干细胞移植(HSCT)等相关治疗,多数患儿最终发展为骨髓衰竭而死亡。近年来随着对该病发病机制的深入研究及HSCT的广泛开展,许多患儿已得到成功救治。国内关于

Blood:敲除CK2β基因可以减少血栓形成,甚至可降低中风风险。

血小板,巨核细胞分裂出的无核细胞质,在止血和动脉血栓形成过程中发挥重要作用。酪蛋白激酶2(CK2)在巨核细胞和血小板中都可以检测到,对于CK2依赖性信号通路对巨噬细胞/血小板的病理生理机制的作用尚不明确。

Nat Med:巨核细胞可控制造血干细胞 有望治疗多种疾病

巨核细胞被认为是产生血小板愈合伤口最好的细胞,这些在骨髓中发现的巨大细胞在调节干细胞上也扮演着重要的角色,这是近日来自美国密苏里州斯托瓦斯医学研究所(Stowers Institute for Medical Research)的研究人员的一项重大研究发现,相关研究成果刊登于国际杂志Nature Medicine上。 实际上,造血干细胞在骨髓中可以分化形成巨核细胞,而本文研究者也首次发现造血

Baidu
map
Baidu
map
Baidu
map