Baidu
map

CLIN CHEM:如何识别早期胆道闭锁?

2017-06-09 MedSci MedSci原创

胆道闭锁诊断的延误是导致终末期肝功能衰竭和肝移植的重要原因。近日,国际杂志 《CLIN CHEM》上在线发表一项关于使用使用直接胆红素反射测试识别早期胆道闭锁的研究。

胆道闭锁诊断的延误是导致终末期肝功能衰竭和肝移植的重要原因。近日,国际杂志 《CLIN CHEM》上在线发表一项关于使用使用直接胆红素反射测试识别早期胆道闭锁的研究。

研究人员回顾性分析胆总管胆红素与直接胆红素测量的时间间隔。此外还审查了两个主要实验室对直接胆红素进行反射测试的的结果。此外,还评估了直接胆红素(> 1.5 mg/dL;> 25μmol/ L)升高的婴儿中反射测试的临床影响以及成本。

在已知胆道闭锁的患者中,46%(40/87)的患者中直接胆红素测量优于分离的总胆红素测量。中位延迟19天(四分间距为3-44天)。在社区环境中,直接胆红素对胆道闭锁的临床特异性高于医院。直接胆红素报告导致1591名年龄小于2周龄的婴儿在医院接受三次入院,其中一名被诊断患有胆道闭锁。对于每个新诊断的胆道闭锁病例,两个实验室直接胆红素测试的费用估计为3200美元(4600新西兰元)。

研究认为直接胆红素未充分利用是延迟胆汁闭锁的原因,并表明对黄疸婴儿进行直接胆红素的反射测试是一种经济有效的解决方案。

原始出处:

Leo Lam, Samarina Musaad, Campbell Kyle,et al. Utilization of Reflex Testing for Direct Bilirubin in the Early Recognition of Biliary Atresia.May.2017

本文系梅斯医学(MedSci)原创编译整理,转载需授权!


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=210297, encodeId=d04421029e5b, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 13 18:52:59 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463965, encodeId=86761463965a1, content=<a href='/topic/show?id=c5af8355eea' target=_blank style='color:#2F92EE;'>#胆道闭锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83557, encryptionId=c5af8355eea, topicName=胆道闭锁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 11 13:21:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208942, encodeId=cd1420894281, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sat Jun 10 10:48:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208738, encodeId=330b208e38ab, content=有新意不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Jun 10 00:04:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-13 虈亣靌

    不错的,学习了!谢谢分享!

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=210297, encodeId=d04421029e5b, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 13 18:52:59 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463965, encodeId=86761463965a1, content=<a href='/topic/show?id=c5af8355eea' target=_blank style='color:#2F92EE;'>#胆道闭锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83557, encryptionId=c5af8355eea, topicName=胆道闭锁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 11 13:21:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208942, encodeId=cd1420894281, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sat Jun 10 10:48:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208738, encodeId=330b208e38ab, content=有新意不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Jun 10 00:04:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=210297, encodeId=d04421029e5b, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 13 18:52:59 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463965, encodeId=86761463965a1, content=<a href='/topic/show?id=c5af8355eea' target=_blank style='color:#2F92EE;'>#胆道闭锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83557, encryptionId=c5af8355eea, topicName=胆道闭锁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 11 13:21:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208942, encodeId=cd1420894281, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sat Jun 10 10:48:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208738, encodeId=330b208e38ab, content=有新意不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Jun 10 00:04:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-10 我是谁??

    学习了。。。。

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=210297, encodeId=d04421029e5b, content=不错的,学习了!谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Tue Jun 13 18:52:59 CST 2017, time=2017-06-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1463965, encodeId=86761463965a1, content=<a href='/topic/show?id=c5af8355eea' target=_blank style='color:#2F92EE;'>#胆道闭锁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=47, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83557, encryptionId=c5af8355eea, topicName=胆道闭锁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Jun 11 13:21:00 CST 2017, time=2017-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208942, encodeId=cd1420894281, content=学习了。。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo51eheDrP8dFkRicVB5LyaVk2Nc1S87J8nCBgASWQ4rrorsyzzr0UzN8N5bibeqGofE7ZtdT6YNZHEQ/0, createdBy=28d72072417, createdName=我是谁??, createdTime=Sat Jun 10 10:48:04 CST 2017, time=2017-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=208738, encodeId=330b208e38ab, content=有新意不错的研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat Jun 10 00:04:52 CST 2017, time=2017-06-10, status=1, ipAttribution=)]
    2017-06-10 飛歌

    有新意不错的研究

    0

相关资讯

NEJM:简单血检可筛查婴儿胆道闭锁

最近,得克萨斯儿童医院(Texas Children’s Hospital)和贝勒医学院(Baylor College of Medicine)的医学研究人员找到了一种简单的血液测试方法来诊断检测新生儿的胆道闭锁(biliary atresia)及其它一些新生儿肝脏疾病。他们的研究发表在了最新一期的国际知名《新英格兰医学杂志》(NEJM)。患有胆道闭锁的新生婴儿往往有生命危险,现有疾病筛选手段还很

Baidu
map
Baidu
map
Baidu
map