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Diabetologia：胰岛素分泌和清除的作用？

2018-04-12 MedSci MedSci原创

胰岛素分泌清除
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近日，国际杂志 《Diabetologia》上在线发表一项关于适应肥胖的胰岛素抵抗-胰岛素分泌和清除的作用的研究。这项研究的目的是量化在无糖尿病的胰岛素抵抗个体的代偿性高胰岛素血症特征中增加的胰岛素分泌率（ISR）和降低的胰岛素清除率（ICR）的相对贡献。 研究人员从志愿者登记处确定肥胖（BMI≥30 kg/m 2）的无糖尿病个体（n = 91）。并对志愿者进行了以下测量：口服葡萄糖耐量；胰

近日，国际杂志 《Diabetologia》上在线发表一项关于适应肥胖的胰岛素抵抗-胰岛素分泌和清除的作用的研究。这项研究的目的是量化在无糖尿病的胰岛素抵抗个体的代偿性高胰岛素血症特征中增加的胰岛素分泌率（ISR）和降低的胰岛素清除率（ICR）的相对贡献。 研究人员从志愿者登记处确定肥胖（BMI≥30 kg/m 2）的无糖尿病个体（n = 91）。并对志愿者进行了以下测量：口服葡萄糖耐量；胰岛素抵抗（胰岛素抑制试验[IST]期间的稳态血浆葡萄糖[SSPG]浓度）;ISR（使用分级葡萄糖输注试验[GGIT]）和ICR（使用IST和GGIT）。根据SSPG浓度分为三等：SSPG-1（对胰岛素敏感）； SSPG-2（中级）和SSPG-3（胰岛素抵抗）。 研究发现SSPG三分位数在BMI和腰围方面没有差异。与SSPG-1组相比，SSPG-2和SSPG-3组的血清丙氨酸转氨酶浓度更高（p=0.02）。在口服葡萄糖激发后，从胰岛素敏感性最高的到胰岛素抵抗最强的三分位组胰岛素总应答量逐渐增加（p<0.001）。在静脉输注葡萄糖后，与SSPG-1组（30.3 [28.8-32.9] mmol /

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    2018-04-12 ms5439512287675881

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    2018-11-18 gwc392

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    2018-07-18 ms9608593228839890

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    #胰岛#

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    2018-04-14 jingyanzhu715_39486101

    #胰岛素分泌#

    0

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