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CLIN CANCER RES：高级别浆液性卵巢癌肿瘤微环境

2017-12-25 MedSci MedSci原创

卵巢癌浆液性肿瘤微环境
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大部分高级别浆液性卵巢癌患者在一线治疗后会出现复发，通常会导致患者死亡。CLIN CANCER RES近期发表了一篇文章，研究原发和复发高级别浆液性卵巢癌的分子生物学特征。

大部分高级别浆液性卵巢癌患者在一线治疗后会出现复发，通常会导致患者死亡。CLIN CANCER RES近期发表了一篇文章，研究原发和复发高级别浆液性卵巢癌的分子生物学特征。

作者分析了66例高级别浆液性卵巢癌患者匹配的原发和复发肿瘤新鲜冰冻标本，进行RNA测序。对匹配的肿瘤标本进行聚类分析和配对比较，并对高级别浆液性卵巢癌的分子特征进行研究。研究结果表明，原发和复发高级别浆液性卵巢癌均表现出显着的微环境基因表达差异，这种差异由控制免疫激活通路的一系列基因和许多参与基质及脂肪组织重塑的基因决定。将肿瘤组织分为免疫活化和免疫沉默组后，作者进一步发现尽管有些复发肿瘤与其原发肿瘤有相同的免疫状态，但有许多复发肿瘤免疫状态发生了变化，免疫从沉默变为活化或从活化变为沉默。有趣的是，属于B7-CD28免疫检查点家族的基因，其主要角色是免疫反应的负向调节因子，在免疫活化肿瘤中过表达。寻找潜在肿瘤抗原时，CEACAM21，癌胚抗原家族的成员之一，在免疫活化的肿瘤中显着过表达。

文章最后认为，这些研究结果说明了高级别浆液性卵巢癌的肿瘤微环境的复杂性并揭示了原发和复发肿瘤之间的关系，有多重治疗意义。

原始出处：
Caroline Kreuzinger,Angelika Geroldinger,et al.A Complex Network of Tumor Microenvironment in Human High-Grade Serous Ovarian Cancer.CLIN CANCER RES.December 2017 doi:10.1158/1078-0432.CCR-17-1159

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2046402, encodeId=2c8a204640220, content=<a href='/topic/show?id=2468368e289' target=_blank style='color:#2F92EE;'>#卵巢癌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36872, encryptionId=2468368e289, topicName=卵巢癌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Fri Dec 07 12:12:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275956, encodeId=39f02e59561e, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Sat Jan 06 09:51:27 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273510, encodeId=27572e351040, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 29 13:05:12 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272453, encodeId=e86e2e245342, content=客观性.公正性.讲得很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Dec 25 18:23:36 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272395, encodeId=a8f92e239571, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Mon Dec 25 11:09:44 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272366, encodeId=20172e236686, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Dec 25 09:45:49 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2018-12-07 nian.wang1982

    #卵巢癌肿瘤#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2046402, encodeId=2c8a204640220, content=<a href='/topic/show?id=2468368e289' target=_blank style='color:#2F92EE;'>#卵巢癌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36872, encryptionId=2468368e289, topicName=卵巢癌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Fri Dec 07 12:12:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275956, encodeId=39f02e59561e, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Sat Jan 06 09:51:27 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273510, encodeId=27572e351040, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 29 13:05:12 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272453, encodeId=e86e2e245342, content=客观性.公正性.讲得很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Dec 25 18:23:36 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272395, encodeId=a8f92e239571, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Mon Dec 25 11:09:44 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272366, encodeId=20172e236686, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Dec 25 09:45:49 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2018-01-06 sunsmile 2017

    很好

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2046402, encodeId=2c8a204640220, content=<a href='/topic/show?id=2468368e289' target=_blank style='color:#2F92EE;'>#卵巢癌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36872, encryptionId=2468368e289, topicName=卵巢癌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Fri Dec 07 12:12:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275956, encodeId=39f02e59561e, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Sat Jan 06 09:51:27 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273510, encodeId=27572e351040, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 29 13:05:12 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272453, encodeId=e86e2e245342, content=客观性.公正性.讲得很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Dec 25 18:23:36 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272395, encodeId=a8f92e239571, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Mon Dec 25 11:09:44 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272366, encodeId=20172e236686, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Dec 25 09:45:49 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-29 虈亣靌

    学习一下谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2046402, encodeId=2c8a204640220, content=<a href='/topic/show?id=2468368e289' target=_blank style='color:#2F92EE;'>#卵巢癌肿瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36872, encryptionId=2468368e289, topicName=卵巢癌肿瘤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6f63175, createdName=nian.wang1982, createdTime=Fri Dec 07 12:12:00 CST 2018, time=2018-12-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=275956, encodeId=39f02e59561e, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKdcWLjLTJBu3e8EwBibOSfO3CicIL8rP3NcFII6cPU1ibCPYbfRp7vXicxxSImo7pLR6Z8bEZB9BibZrA/0, createdBy=44b71653286, createdName=sunsmile 2017, createdTime=Sat Jan 06 09:51:27 CST 2018, time=2018-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=273510, encodeId=27572e351040, content=学习一下谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Fri Dec 29 13:05:12 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272453, encodeId=e86e2e245342, content=客观性.公正性.讲得很不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zMoyicyo6ia9f4IuLQAwZoxD6Hx4ibd5CMcOCYhStY6oDibbKK6O2X8iaicldO5ib8j1iapOIobIKCGiczU2A/0, createdBy=56251941490, createdName=虈亣靌, createdTime=Mon Dec 25 18:23:36 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272395, encodeId=a8f92e239571, content=henhao, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NcXNhUvfhzd2VdicMnaLeK2Im5gKx4Ucxd8Bwu6S7RG0uILBFQx5HTW2bU4VricDYlQqN20ibASSMYAeGrZrrTpy2Q/0, createdBy=b0041939716, createdName=hhh678, createdTime=Mon Dec 25 11:09:44 CST 2017, time=2017-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=272366, encodeId=20172e236686, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=86, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Mon Dec 25 09:45:49 CST 2017, time=2017-12-25, status=1, ipAttribution=)]
    2017-12-25 虈亣靌

    客观性.公正性.讲得很不错

    0

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    2017-12-25 hhh678

    henhao

    0

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    2017-12-25 龙胆草

    学习谢谢分享

    0

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