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Diabetes Care:新发2型糖尿病患者BMI、体重变化与痴呆风险

2019-06-09 xing.T 网络

由此可见,较低的基线BMI与新发2型糖尿病患者全因痴呆和AD风险增加有关。糖尿病诊断后体重减轻或体重增加与全因痴呆的风险增加有关。体重减轻与AD风险增加有关。

近日,糖尿病领域权威杂志Diabetes Care上发表了一篇研究文章,该研究旨在评估新诊断2型糖尿病患者的基线BMI、体重变化百分比与痴呆风险之间的关系。

研究人员使用韩国国民健康保险服务-国家健康评估队列数据库,在2007年至2012年间确定了167876名年龄≥40岁的被诊断患有新发2型糖尿病的受试者。他们的体重变化在诊断后2年被监测,随访评估平均为3.5年。研究人员使用多变量Cox比例风险回归模型估计全因痴呆、阿尔茨海默病(AD)和血管性痴呆的风险比(HRs)和Bonferroni调整的95%CI。 

研究人员在随访期间确定了2563例罹患痴呆的病例。新发2型糖尿病患者的基线BMI与全因痴呆和AD的风险呈负相关,与混杂变量无关(趋势P<0.001)。诊断为2型糖尿病后2年内体重变化百分比显示出与全因痴呆发展风险呈显著的U形关联(P<0.001); 当体重减轻或增重>10%(分别为1.34 [95%CI为1.11-1.63]和1.38[1.08-1.76])时,该疾病的HR显著增加。此外,体重减轻>10%与AD风险增加有关(HR为1.26[95%CI为1.01-1.59])。

由此可见,较低的基线BMI与新发2型糖尿病患者全因痴呆和AD风险增加有关。糖尿病诊断后体重减轻或体重增加与全因痴呆的风险增加有关。体重减轻与AD风险增加有关。 

原始出处:


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    2020-01-04 zhouqu_8
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  8. 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time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367542, encodeId=04c036e5429f, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Jun 10 11:43:11 CST 2019, time=2019-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042499, encodeId=36d4104249904, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jun 09 20:21:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048541, encodeId=9e6e10485419d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Jun 09 20:21:00 CST 2019, time=2019-06-09, status=1, ipAttribution=)]
    2019-06-10 130****4638

    学习了,谢谢分享。

    0

  9. 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time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367542, encodeId=04c036e5429f, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Jun 10 11:43:11 CST 2019, time=2019-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042499, encodeId=36d4104249904, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jun 09 20:21:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048541, encodeId=9e6e10485419d, content=老年人痴呆何药可用??, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=junJUN, createdTime=Sun Jun 09 20:21:00 CST 2019, time=2019-06-09, status=1, ipAttribution=)]
    2019-06-09 misszhang

    谢谢MedSci提供最新的资讯

    0

  10. 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time=2019-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367542, encodeId=04c036e5429f, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Jun 10 11:43:11 CST 2019, time=2019-06-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1042499, encodeId=36d4104249904, content=谢谢MedSci提供最新的资讯, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=misszhang, createdTime=Sun Jun 09 20:21:00 CST 2019, time=2019-06-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1048541, encodeId=9e6e10485419d, content=老年人痴呆何药可用??, 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    2019-06-09 junJUN

    老年人痴呆何药可用??

    0

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