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港科大与北京天坛医院研发治疗脑癌新药,最快2年后投入治疗

2018-12-04 佚名 中国新闻网

据香港《明报》报道,香港医院管理局每年录得200宗恶性脑肿瘤新症,当中约1/4为“低级别神经胶质瘤”,大部分会早10年内恶化成致命的“继发性胶质母细胞瘤(sGBM)”。香港科技大学与北京天坛医院组成的研究团队用了2年时间,发现sGBM的基因突变机制,并成功配对药物完成一期临床试验,目前正做二期临床试验,预计最快2年后药物可投入治疗。据报道,科大生命科学部兼化学及生物工程学系助理教授王吉光领导的研究

据香港《明报》报道,香港医院管理局每年录得200宗恶性脑肿瘤新症,当中约1/4为“低级别神经胶质瘤”,大部分会早10年内恶化成致命的“继发性胶质母细胞瘤(sGBM)”。香港科技大学与北京天坛医院组成的研究团队用了2年时间,发现sGBM的基因突变机制,并成功配对药物完成一期临床试验,目前正做二期临床试验,预计最快2年后药物可投入治疗。

据报道,科大生命科学部兼化学及生物工程学系助理教授王吉光领导的研究团队,在2016年开展研究,设计数据运算模型,分析及整合188个sGBM病人的胶质瘤样本数据,并从当中80多个含RNA测序(RNA Sequencing)的样本当中,发现约14%的MET基因出现突变。MET基因突变可导致细胞降解有害蛋白的能力下降,令有害蛋白在细胞内积聚,发展成致命的sGBM。

根据这发现,北京天坛医院的研究团队为该基因突变配对针对性标靶药物PLB-1001,并招募了18名晚期sGBM患者作临床试验。结果显示,部分患者对药物有积极反应,更有2名患者的脑肿瘤在12周内明显缩小,甚至消失。7名患者的病情稳定,药物也没有呈明显副作用。目前研究已进入二期临床试验阶段,预计最快2年后药物可投入治疗。

虽然在临床试验中,脑肿瘤在12周内明显缩小,但由于会出现抗药性,现阶段不能排除复发的可能。王吉光表示,脑肿瘤会随着治疗不断变化,是一个动态过程,他们的运算模型除可发现令脑肿瘤演化成sGBM的基因突变,未来也可研究从大量的脑肿瘤样本数据中找出其变化规律,并利用机器学习的方法预测患者脑肿瘤发展进程。

团队目前已联同香港中文大学医学院开展跨校联合研究项目,前期先搜集患者的病理学、样本基因图谱、 磁力共振影像等数据。待积累数据后,便可建立人工智能系统,长远可利用系统自动辨识患者脑肿瘤发展进程,预测脑肿瘤的变化,辅助医生决定合适治疗方案。

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    2018-12-06 lqvr
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