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Antim. Agents Chemother.:抗抑郁药氟西汀也能抗肠道病毒

2012-07-30 ZinFingerNase 生物谷

氟西汀分子结构式。 来自美国加州大学洛杉矶分校的研究人员意外发现氟西汀(fluoxetine, 也译作氟苯氧丙胺)---常被称作百忧解(Prozac)--的一种潜在的新用途:它有望作为抗病毒试剂发挥作用。这一发现可能提供另一种工具来治疗导致人们患病和死亡的人肠道病毒(enterovirus)感染。 当前还不存在抗病毒药物来治疗肠病毒感染,而且该病毒感染经常是严重性的和潜在致命性的。氟西汀是一类


氟西汀分子结构式。

来自美国加州大学洛杉矶分校的研究人员意外发现氟西汀(fluoxetine, 也译作氟苯氧丙胺)---常被称作百忧解(Prozac)--的一种潜在的新用途:它有望作为抗病毒试剂发挥作用。这一发现可能提供另一种工具来治疗导致人们患病和死亡的人肠道病毒(enterovirus)感染。

当前还不存在抗病毒药物来治疗肠病毒感染,而且该病毒感染经常是严重性的和潜在致命性的。氟西汀是一类经常被用于治疗抑郁症、焦虑症和一些人格障碍的药物。鉴于该药物具有良好的药物动力学和安全特性,研究人员发现这一项研究表明氟西汀有潜力作为抗病毒试剂来治疗肠病毒感染。

利用分子筛选方法,来自加州大学洛杉矶分校的一个研究小组发现氟西汀是一种强效地抑制柯萨奇病毒(coxsackievirus)复制的抑制剂。该病毒是包括脊髓灰质炎病毒(polio virus)和在胃肠道中发现的埃可病毒(echovirus)在内的病毒之一。感染上这种病毒会导致其他机会性感染和疾病。

研究人员说,理解氟西汀和诺氟西汀(norfloxetine)对抗柯萨奇病毒的作用机制将有助于人们肠道病毒复制和评估它们潜在的临床疗效以便在未来开发出治疗严重性肠道病毒感染的方法。研究人组发现氟西汀并不干扰病毒进入宿主细胞,也不干扰病毒基因组翻译。相反,氟西汀和诺氟西汀显著性地降低病毒RNA和蛋白产生。

本文编译自Fluoxetine -- a.k.a., Prozac -- is effective as an anti-viral: study

doi: 10.1128/​AAC.00983-12
PMC:
PMID:

Fluoxetine is a Potent Inhibitor of Coxsackievirus Replication

Jun Zuo1, Kevin K. Quinn1, Steve Kye1, Paige Cooper1, Robert Damoiseaux2 and Paul Krogstad

No antiviral drugs currently exist for the treatment of enterovirus infections, which are often severe and potentially life-threatening. Molecular screening of small molecule libraries identified fluoxetine, a selective serotonin reuptake inhibitor, as a potent inhibitor of coxsackievirus replication. Fluoxetine did not interfere with either viral entry or translation of the viral genome. Instead, fluoxetine and its metabolite norfluoxetine markedly reduced the synthesis of viral RNA and protein. In view of its favorable pharmacokinetics and safety profile, fluoxetine warrants additional study as a potential antiviral agent for enterovirus infections.

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    2022-12-22 ms9000000196853431 来自陕西省

    氟西汀可能能够治疗或预防新冠。这里有没有精神科的同事?统计一用氟西汀治疗的抑郁症患者感染新冠的情况。

    0

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    2013-06-06 wjywjy
  3. [GetPortalCommentsPageByObjectIdResponse(id=2107054, encodeId=e392210e05400, content=氟西汀可能能够治疗或预防新冠。这里有没有精神科的同事?统计一用氟西汀治疗的抑郁症患者感染新冠的情况。, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bd8486929, createdName=ms9000000196853431, createdTime=Thu Dec 22 13:29:37 CST 2022, time=2022-12-22, status=1, ipAttribution=陕西省), GetPortalCommentsPageByObjectIdResponse(id=1779538, encodeId=c3e11e7953813, content=<a href='/topic/show?id=0473209562' target=_blank style='color:#2F92EE;'>#agents#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2095, encryptionId=0473209562, topicName=agents)], attachment=null, authenticateStatus=null, createdAvatar=/img/user_icon.png, createdBy=1072181, createdName=wjywjy, createdTime=Thu Jun 06 02:54:00 CST 2013, time=2013-06-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779475, encodeId=43261e7947587, content=<a href='/topic/show?id=481a2094a9' target=_blank style='color:#2F92EE;'>#Agent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2094, encryptionId=481a2094a9, topicName=Agent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Sun Dec 02 07:54:00 CST 2012, time=2012-12-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1722392, encodeId=7d901e22392f4, content=<a href='/topic/show?id=7ff5549865a' target=_blank style='color:#2F92EE;'>#抑郁药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54986, encryptionId=7ff5549865a, topicName=抑郁药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78fa33270286, createdName=wetgdt, createdTime=Sun Jan 13 08:54:00 CST 2013, time=2013-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1454599, encodeId=4d9a14545990c, content=<a href='/topic/show?id=2bd981e071f' target=_blank style='color:#2F92EE;'>#肠道病毒#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81707, encryptionId=2bd981e071f, topicName=肠道病毒)], attachment=null, authenticateStatus=null, createdAvatar=/v1.0.0/img/user_icon.png, createdBy=2a9a5579963, createdName=liye789132253, createdTime=Wed Aug 01 03:54:00 CST 2012, time=2012-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1492099, encodeId=31651492099b0, content=<a href='/topic/show?id=7999553333c' target=_blank style='color:#2F92EE;'>#抗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55333, encryptionId=7999553333c, topicName=抗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a59b8920619, createdName=wushaoling, createdTime=Wed Aug 01 03:54:00 CST 2012, time=2012-08-01, status=1, ipAttribution=)]
    2012-12-02 grace5700
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    2013-01-13 wetgdt
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