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Clinical Translational Gastroenterology: 代谢性健康肥胖和糜烂性食管炎之间的关系

2019-12-11 不详 MedSci原创

肥胖是糜烂性食管炎的已知危险因素,代谢不健康与糜烂性食管炎的发病机制有关。然而,在没有与肥胖相关的代谢性不健康(称为“代谢健康的肥胖(MHO)”)的肥胖个体中,发生侵蚀性食管炎的风险尚不清楚,本项研究旨在研究一组代谢健康个体的体重指数(BMI)与糜烂性食管炎之间的关系。

目的:
肥胖是糜烂性食管炎的已知危险因素,代谢不健康与糜烂性食管炎的发病机制有关。然而,在没有与肥胖相关的代谢性不健康(称为“代谢健康的肥胖(MHO)”)的肥胖个体中,发生侵蚀性食管炎的风险尚不清楚,本项研究旨在研究一组代谢健康个体的体重指数(BMI)与糜烂性食管炎之间的关系。

方法:
研究人员进行了一项队列研究,研究了14725名无症状的无侵蚀性食管炎和代谢异常的成年人,代谢健康定义为不具有代谢综合征,且胰岛素抵抗的动态平衡模型评估<2.5。研究人员使用内窥镜检查确定是否有糜烂性食管炎的存在。

结果:
在81385.2人年的随访期间,有1865名参与者发生了糜烂性食管炎(发生率,每1 000人年22.9)。相对于正常体重参与者(18.5-22.9),超重(BMI 23.0-24.9)和肥胖(≥25)的糜烂性食管炎的多变量校正风险比为1.12(1.00-1.25)和1.29(1.14–1.47)。在剂量反应分析中,BMI升高也与总体和LA-B级或更高呈正相关。腰围大小也与糜烂性食管炎的发展之间的关联也很明显。

讨论:
在代谢健康的男女中,MHO表型与糜烂性食管炎的发生率增加相关,表明MHO表型对食管反流疾病没有保护作用。

原始出处:
Kim, Tae Jun. et al. Metabolically Healthy Obesity and the Risk of Erosive Esophagitis. Clinical and Translational Gastroenterology. 2019.

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channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25430, encryptionId=5e202543023, topicName=代谢性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6cc1239, createdName=sodoo, createdTime=Mon Oct 19 09:18:00 CST 2020, time=2020-10-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2072812, encodeId=6ad020e28122f, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Mon Mar 30 01:18:00 CST 2020, time=2020-03-30, status=1, 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style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504864, encodeId=08d21504864ac, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
    2020-10-19 sodoo
  5. 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style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504864, encodeId=08d21504864ac, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
    2020-03-30 仁心济世
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796017, encodeId=87731e960171a, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Fri May 08 15:18:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657273, encodeId=0e8c165e273f0, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, 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style='color:#2F92EE;'>#食管炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101081, encryptionId=d627101081d8, topicName=食管炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b8756488272, createdName=天堂的云, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504864, encodeId=08d21504864ac, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=)]
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1796017, encodeId=87731e960171a, content=<a href='/topic/show?id=8c201e758e5' target=_blank style='color:#2F92EE;'>#translational#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17758, encryptionId=8c201e758e5, topicName=translational)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d81c2500028, createdName=12498561m32(暂无昵称), createdTime=Fri May 08 15:18:00 CST 2020, time=2020-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1657273, encodeId=0e8c165e273f0, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Sun May 24 19:18:00 CST 2020, time=2020-05-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437500, encodeId=e0b5143e5000f, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Fri Dec 13 03:18:00 CST 2019, time=2019-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1462536, encodeId=5e7714625366a, content=<a href='/topic/show?id=d627101081d8' target=_blank 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ipAttribution=)]
    2020-05-24 bsmagic9140
  8. 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    2019-12-13 zhouqu_8
  9. 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  10. 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