CLIN CANCER RES：CSF1R基因改变通过改变巨噬细胞功能调节肿瘤免疫

2017-10-27 MedSci MedSci原创

通过抑制集落刺激因子1（CSF-1R）靶向肿瘤相关巨噬细胞是肿瘤治疗的策略之一。CLIN CANCER RES近期发表了一篇文章，研究CSF1R基因改变对CSF-1R信号以及CSF-1R抑制剂敏感性的影响。

通过抑制集落刺激因子1（CSF-1R）靶向肿瘤相关巨噬细胞是肿瘤治疗的策略之一。CLIN CANCER RES近期发表了一篇文章，研究CSF1R基因改变对CSF-1R信号以及CSF-1R抑制剂敏感性的影响。

作者研究了140例肿瘤患者中CSF1R基因改变情况。检测CSF-1R磷酸化，细胞内吞作用以及巨噬细胞极化以了解对CSF-1刺激的反应。利用肿瘤组织标本中的肿瘤相关巨噬细胞以及对CSF-1R抑制剂敏感性研究巨噬细胞功能。研究结果发现CSF1R c.1085＞G基因改变是在在东亚人群中出现的高频率等位基因。存在这种等位基因变化的肿瘤患者M2样肿瘤相关巨噬细胞更少，且伴随肿瘤组织中VEGF低表达。重要的是，CSF1R基因改变与结直肠癌、子宫内膜癌以及卵巢癌无病生存显着相关。存在CSF1R c.1085＞G基因改变的巨噬细胞对CSF-1刺激具有抵抗性。IC50在0.1nmol/L到1nmol/L时，巨噬细胞对CSF-1R抑制剂敏感。CSF-1诱导磷酸化以及CSF-1R快速内吞作用，导致CSF1Rc.1085基因型A_A巨噬细胞M2样磷酸化，其中IC50在10nmol/L到100nmol/L时，PLX3997，BLZ945和GW2580抑制剂抑制巨噬细胞生存。

文章最后认为，CSF1R c.1085＞G基因改变通过改变巨噬细胞磷酸化和功能调节肿瘤免疫作用，可以作为靶向CSF-1R信号进行肿瘤治疗的分子标志。

原始出处：

Yu-Min Yeh,Shan-Ju Hsu,et al.The c.1085A＞G Genetic Variant of CSF1R Gene Regulates Tumor Immunity by Altering the Proliferation,Polarization,and Function of Marcrophages.CLIN CANCER RES.October 2017 doi:10.1158/1078-0432.CCR-17-1007

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#插入话题

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2017-11-05 12498adam51暂无昵称

#基因改变#

50 0
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2018-09-26 kcb078

#CSF#

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2017-12-17 839640778

#CSF1#

40 0
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2018-05-17 ms7899726347904398

#CSF1R#

33 0
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2017-11-17 微分

学习学习了.谢谢啦

81 0
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2017-11-07 微分

非常好.幸亏个子低

82 0
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2017-10-29 般若傻瓜

#细胞功能#

29 0
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2017-10-28 flysky120

学习一下知识了

87 0
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2017-10-27 明天会更好！

不错的文章值得推荐一下

95 0

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