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BJC:乳腺癌患者因副作用停药增复发风险

2013-09-06 MedSci原创 MedSci原创

它莫西芬乳腺癌
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乳腺癌患者在接受手术或化疗后，常被要求继续服用名为“它莫西芬”的药物以防复发。但由于这种药有副作用，许多患者往往不按医嘱，擅自停药。英国一项新研究显示，停药将增大患者癌症复发和死亡的风险。英国苏格兰格拉斯哥大学研究人员在《英国癌症期刊》上报告说，他们对 1263 名乳腺癌患者的处方记录和服药情况进行了跟踪调查，发现一些患者因为出现潮热、关节痛、疲惫或体重增加等副作用，没有按医生要求坚持服用它莫西芬

乳腺癌患者在接受手术或化疗后，常被要求继续服用名为“它莫西芬”的药物以防复发。但由于这种药有副作用，许多患者往往不按医嘱，擅自停药。英国一项新研究显示，停药将增大患者癌症复发和死亡的风险。

英国苏格兰格拉斯哥大学研究人员在《英国癌症期刊》上报告说，他们对 1263 名乳腺癌患者的处方记录和服药情况进行了跟踪调查，发现一些患者因为出现潮热、关节痛、疲惫或体重增加等副作用，没有按医生要求坚持服用它莫西芬。【原文下载】

研究人员将按期服药率不足 80% 的患者认定为“对坚持治疗配合度低”，并分析了她们的癌症复发风险。研究显示，未坚持服药的人群癌症复发和死亡风险都更高，而且因住院治疗或服用其他药物，她们需要负担人均近 6000 英镑的额外支出。

研究人员说，英国每年约有 1.3 万名乳腺癌患者被医生要求连续5年服用它莫西芬，但许多患者因副作用擅自停药，由此造成的不必要死亡病例估计每年超过 430 例，额外支出高达数百万英镑。

英国“乳腺癌运动”组织首席执行官摩根说，它莫西芬药效显著，但可能在部分人群中引发副作用。这项研究一方面提醒患者，应坚持按医嘱服药；另一方面也告诫医生，应帮助患者坚持服药，并尽量克服可能出现的副作用。

原文下载

McCowan C, Wang S, Thompson AM, Makubate B, Petrie DJ.The value of high adherence to tamoxifen in women with breast cancer: a community-based cohort study.Br J Cancer. 2013 Sep 3;109(5):1172-80. 

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    2014-06-11 showtest

    #副作用#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1824178, encodeId=54fd18241e89d, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Wed Jun 11 10:26:00 CST 2014, time=2014-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905437, encodeId=a6be190543e3e, content=<a href='/topic/show?id=0eb34259ea1' target=_blank style='color:#2F92EE;'>#复发风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42597, encryptionId=0eb34259ea1, topicName=复发风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat May 10 15:26:00 CST 2014, time=2014-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460776, encodeId=36191460e7645, content=<a href='/topic/show?id=b8012e675d7' target=_blank style='color:#2F92EE;'>#停药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27675, encryptionId=b8012e675d7, topicName=停药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d6379100, createdName=yinhl1980, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570915, encodeId=48b215e0915c7, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=)]
    2014-05-10 wushaoling

    #复发风险#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1824178, encodeId=54fd18241e89d, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Wed Jun 11 10:26:00 CST 2014, time=2014-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905437, encodeId=a6be190543e3e, content=<a href='/topic/show?id=0eb34259ea1' target=_blank style='color:#2F92EE;'>#复发风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42597, encryptionId=0eb34259ea1, topicName=复发风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat May 10 15:26:00 CST 2014, time=2014-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460776, encodeId=36191460e7645, content=<a href='/topic/show?id=b8012e675d7' target=_blank style='color:#2F92EE;'>#停药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27675, encryptionId=b8012e675d7, topicName=停药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d6379100, createdName=yinhl1980, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570915, encodeId=48b215e0915c7, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=)]
    2013-09-08 yinhl1980

    #停药#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1824178, encodeId=54fd18241e89d, content=<a href='/topic/show?id=56a932e7800' target=_blank style='color:#2F92EE;'>#副作用#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32778, encryptionId=56a932e7800, topicName=副作用)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Wed Jun 11 10:26:00 CST 2014, time=2014-06-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1905437, encodeId=a6be190543e3e, content=<a href='/topic/show?id=0eb34259ea1' target=_blank style='color:#2F92EE;'>#复发风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=42597, encryptionId=0eb34259ea1, topicName=复发风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca20190, createdName=wushaoling, createdTime=Sat May 10 15:26:00 CST 2014, time=2014-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460776, encodeId=36191460e7645, content=<a href='/topic/show?id=b8012e675d7' target=_blank style='color:#2F92EE;'>#停药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27675, encryptionId=b8012e675d7, topicName=停药)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3c6d6379100, createdName=yinhl1980, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570915, encodeId=48b215e0915c7, content=<a href='/topic/show?id=f42823e48d7' target=_blank style='color:#2F92EE;'>#乳腺癌患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23748, encryptionId=f42823e48d7, topicName=乳腺癌患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=37bc15724202, createdName=hanhaisha2013, createdTime=Sun Sep 08 05:26:00 CST 2013, time=2013-09-08, status=1, ipAttribution=)]
    2013-09-08 hanhaisha2013

    #乳腺癌患者#

    0

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