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Eur J Cancer:吉西他滨+白蛋白结合型紫杉醇对比FOLFIRINOX一线治疗晚期胰腺癌疗效和安全性

2021-05-10 yd2015 MedSci原创

吉西他滨+白蛋白结合型紫杉醇对比FOLFIRINOX一线治疗晚期胰腺癌疗效相当

胰腺癌是常见的恶性肿瘤,恶性程度高。晚期胰腺癌5年中位生存(OS)只有3%左右。吉西他滨+白蛋白结合型紫杉醇方案一线治疗能够提高胰腺癌的生存。同样,FOLFIRINOX或调整的FOLFIRINOX方案一线治疗也可改善胰腺癌的预后。但是,目前没有头对头研究比较两者的疗效和安全性。

本研究旨在比较吉西他滨+白蛋白结合型紫杉醇(GN)对比FOLFIRINOX一线治疗晚期胰腺癌疗效和安全性。这是一项多中心的回顾性的队列研究。主要研究终点为总生存(OS),次要终点为无疾病进展生存(PFS),客观缓解率(ORR)和疾病控制率(DCR)以及安全性。

研究纳入了455例晚期胰腺癌患者,其中GN组为297例(65.3%),FOLFIRINOX组为158例(34.7%)。未调整分析,中位OS:GN vs FOLFIRINOX 为10.1个月 vs 11.2个月;经倾向评分调整分析后,中位OS:GN vs FOLFIRINOX 为10.1个月 vs 10.1个月。两组无明显统计学差异。

                                                      两组OS

未调整分析,中位PFS:GN vs FOLFIRINOX 为4.6个月 vs 4.8个月;经倾向评分调整分析后,两组中位PFS也无明显统计学差异。

                                         两组PFS

治疗相关不良事件分析两组也是相当的。

                          治疗相关不良事件

综上,吉西他滨+白蛋白结合型紫杉醇对比FOLFIRINOX一线治疗晚期胰腺癌疗效相当。

 

原始出处:

Jakob M Riedl , Florian Posch , Lena Horvath,et al. Gemcitabine/nab-Paclitaxel versus FOLFIRINOX for palliative fifirst-line treatment of advanced pancreatic cancer: A propensity score analysis. Eur J Cancer. 2021 May 2;151:3-13. doi: 10.1016/j.ejca.2021.03.040. Online ahead of print.

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    2021-05-12 珙桐
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    2021-05-10 内科新手

    谢谢梅斯提供这么好的信息,学到很多

    0

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