Brain：睡眠提高帕金森氏症病人记忆力

一研究人员已经证明经过一夜的睡眠后，患有帕金森氏症的人在记忆测试中明显表现得更好，而睡眠障碍可能会干扰这一效益。

通常帕金森氏症的典型症状包括震颤、动作缓慢等，同时帕金森氏也可以影响一个人的记忆。研究结果强调解决帕金森病患者睡眠障碍的重要性，并指出通过适当的训练可以提高帕金森病患者的工作记忆容量，适当训练的结果对生物学上的睡眠和记忆也会有一定的影响。

该研究结果发表在本周的Brain杂志上。埃默里大学医学院神经学教授博士后研究员、论文第一作者Donald Bliwis说：众所周知睡眠对记忆是有益的，但​​在这项最新研究中，科研人员已经能够分析出记忆的改进需要哪一种类型的睡眠。

从睡眠中的记忆性能的提升与慢波睡眠的量以及睡眠深浅有关。几个研究小组报告说，慢波睡眠对突触的可塑性、脑细胞重组以及新联系建立的能力很重要。

睡眠呼吸暂停即气道阻塞造成的睡眠中断干扰了睡眠对记忆的影响。通过参与研究的受试人员所表现出来的睡眠呼吸暂停迹象发现，如果睡眠呼吸暂停严重到足以降低他们血液中的氧含量超过五分钟的话，这些人的记忆测试将不会有所提升。Scullin和Bliwise计划将研究扩大到健康老人以及神经退行性疾病患者范围中。

编译自：Sleep improves memory in people with Parkinson's disease

doi:10.1093/brain/aws192
PMC:
PMID:

Nocturnal sleep enhances working memory training in Parkinson's disease but not Lewy body dementia

M.K. Scullin, L.M. Trotti, A.G. Wilson, S.A. Greer and D.L. Bliwise.

Working memory is essential to higher order cognition (e.g. fluid intelligence) and to performance of daily activities. Though working memory capacity was traditionally thought to be inflexible, recent studies report that working memory capacity can be trained and that offline processes occurring during sleep may facilitate improvements in working memory performance. We utilized a 48-h in-laboratory protocol consisting of repeated digit span forward (short-term attention measure) and digit span backward (working memory measure) tests and overnight polysomnography to investigate the specific sleep-dependent processes that may facilitate working memory performance improvements in the synucleinopathies. We found that digit span backward performance improved following a nocturnal sleep interval in patients with Parkinson's disease on dopaminergic medication, but not in those not taking dopaminergic medication and not in patients with dementia with Lewy bodies. Furthermore, the improvements in patients with Parkinson's disease on dopaminergic medication were positively correlated with the amount of slow-wave sleep that patients obtained between training sessions and negatively correlated with severity of nocturnal oxygen desaturation. The translational implication is that working memory capacity is potentially modifiable in patients with Parkinson's disease but that sleep disturbances may first need to be corrected.