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Sci Rep:STEAP2敲除能够减少前列腺癌细胞的入侵能力

2018-04-26 AlexYang MedSci原创

与正常前列腺比较,前列腺-2的六次跨膜上皮抗原(STEAP2)表达在前列腺癌中增加,表明了STEAP2也许能够促进前列腺癌的恶化。最近,有研究人员进行了旨在阐明STEAP2在前列腺致瘤过程中的功能作用情况和评估将其敲除后是否能够减少前列腺癌细胞侵入能力的研究。研究人员将STEAP2 siRNA转化进入PC3和LNCaP细胞系中,并且分析了增殖、迁移、入侵和基因表达情况。研究人员根据格林森得分情况,

与正常前列腺比较,前列腺-2的六次跨膜上皮抗原(STEAP2)表达在前列腺癌中增加,表明了STEAP2也许能够促进前列腺癌的恶化。最近,有研究人员进行了旨在阐明STEAP2在前列腺致瘤过程中的功能作用情况和评估将其敲除后是否能够减少前列腺癌细胞侵入能力的研究。

研究人员将STEAP2 siRNA转化进入PC3和LNCaP细胞系中,并且分析了增殖、迁移、入侵和基因表达情况。研究人员根据格林森得分情况,在164名前列腺癌患者中利用STEAP2免疫组化技术来评估蛋白表达和定位情况。研究发现,在STEAP2敲除后,2个细胞系的侵入能力显著减少。PC3增殖和迁移能力均显著减少,并且LNCaP细胞形态和生长特性均发生了改变。另外,STEAP2的与促使侵入相关的下游靶标在PC3细胞中包括MMP3, MMP10, MMP13, FGFR4, IL1β, KiSS1和SERPINE1,在LNCaP细胞中包括MMP7,并且CD82在2个细胞系中均存在。在患者组织中,STEAP2的表达在前列腺癌样本中显著增加,并且与格林森得分显著相关。

最后,研究人员指出,他们的数据阐释了STEAP2能够通过促进增殖、迁移和入侵以及显著影响转移通路中10个基因的转录情况,从而促使恶性前列腺癌性状的产生。

原始出处:

Stephanie E. A. Burnell, Samantha Spencer-Harty, Suzie Howarth et al. STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Sci Rep. 19 April 2018.

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    2018-04-28 yxch36
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    2018-04-27 kafei

    学习学习谢谢分享

    0

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    2018-04-26 13718711b3m

    学习了.获益匪浅.感谢分享

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    2018-04-26 神功盖世

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