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Neurology:睡眠障碍的危险因素和帕金森病有相似之处,但亦有不同

2020-12-26 Freeman MedSci原创

 
REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关,这些表现可体现在多导睡眠图(PSG)上。先前的纵向研究表明,特发性 RBD (iRBD) 患者发生神经退行性疾病的风险增加,主要是 α- 突触核蛋白病,包括帕金森病(PD)、路易氏体型失智症(DLB)和多系统萎缩症。超过80% 的 iRBD 患者将在十年或更长时间后发展成为这些神经退行性疾病。
 
鉴于 iRBD 与突触核蛋白介导的神经退行性疾病之间的密切关系,研究 iRBD 的危险因素对于揭示 α- 突触核蛋白病的病因和发病机制以及制定预防策略具有重要意义。近年来,一些大规模的基于人群的研究探讨了 RBD 的危险因素。这些研究大多使用问卷作为诊断 RBD 的筛选工具,因为 PSG 的开展是耗时、昂贵和不可行的。这些研究报道 RBD 不仅与帕金森病和痴呆症有共同的危险因素,如头部损伤、低教育水平等,而且还有一些独特的危险因素,包括吸烟和饮酒。然而,以前的研究没有详细探究其他的重要因素,比如一氧化碳(CO)中毒、帕金森病或痴呆的家族史,以及帕金森病的其他前驱症状,等等。
 
首都医科大学宣武医院的团队,基于Beijing Longitudinal Study on Aging II (BLSA II) cohort,他们分析了在7225名没有帕金森综合症和痴呆症的参与者。并通过RBD量表(RBD questionnaire-Hong Kong)评估可能的RBD (Possible RBD,pRBD)患者。结果发现,219人(3.0%)被认为患有 pRBD。pRBD 参与者具有更多帕金森病(PD)的非运动和运动症状。pRBD 的参与者更有可能具有帕金森综合症或痴呆症的家族史。pRBD 与高脂血症、吸烟、一氧化碳中毒、非职业杀虫剂暴露显著相关。
 
这个基于北京衰老队列的研究,主要的临床意义在于:一方面,进一步验证了之前报道的 pRBD 与高脂血症、吸烟、农药暴露和多种 PD前驱症状之间的关系。另一方面,他们新发现了:帕金森病/痴呆症的家族史、一氧化碳中毒是pRBD的危险因素。pRBD的风险因素和PD有相似之处,但也有不同。

 

Risk factors for possible REM sleep behavior disorders-A community-based study in Beijing
Hui Zhang, Zhuqin Gu, Chun Yao, Yanning Cai, Yuan Li, Wei Mao, Erhe Xu, Ronald B. Postuma, Piu Chan
Neurology Oct 2020, 95 (16) e2214-e2224; DOI: 10.1212/WNL.0000000000010610

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    2021-11-09 湘雅科教

    已拜读,受益匪浅。

    0

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    2021-02-03 yinhl1978
  3. [GetPortalCommentsPageByObjectIdResponse(id=1068460, encodeId=95f81068460c9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:26:24 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001177, encodeId=35b420011e777, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Feb 03 23:58:50 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911176, encodeId=bd309111e61f, content=很好的文章<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:47:18 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911148, encodeId=9a3e91114865, content=REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 26 21:46:42 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911114, encodeId=71e691111412, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Dec 26 18:13:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911036, encodeId=0fab91103687, content=学习学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Dec 26 09:56:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911028, encodeId=56e29110280f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201208/d1f232a1b61443dc893e8ff95474e60b/7ad7474277f6427eb1c2305a87e1c4b2.jpg, createdBy=1a665432979, createdName=Lydia-1110, createdTime=Sat Dec 26 09:19:31 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911012, encodeId=0deb911012b0, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Dec 26 07:53:31 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 医路顺丰

    很好的文章#学习#学习了

    0

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    2020-12-26 三生有幸9135

    REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关

    0

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    2020-12-26 13c30453m58暂无昵称

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1068460, encodeId=95f81068460c9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:26:24 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001177, encodeId=35b420011e777, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Feb 03 23:58:50 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911176, encodeId=bd309111e61f, content=很好的文章<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:47:18 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911148, encodeId=9a3e91114865, content=REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 26 21:46:42 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911114, encodeId=71e691111412, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Dec 26 18:13:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911036, encodeId=0fab91103687, content=学习学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Dec 26 09:56:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911028, encodeId=56e29110280f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201208/d1f232a1b61443dc893e8ff95474e60b/7ad7474277f6427eb1c2305a87e1c4b2.jpg, createdBy=1a665432979, createdName=Lydia-1110, createdTime=Sat Dec 26 09:19:31 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911012, encodeId=0deb911012b0, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Dec 26 07:53:31 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 易水河

    学习学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1068460, encodeId=95f81068460c9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:26:24 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001177, encodeId=35b420011e777, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Feb 03 23:58:50 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911176, encodeId=bd309111e61f, content=很好的文章<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:47:18 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911148, encodeId=9a3e91114865, content=REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 26 21:46:42 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911114, encodeId=71e691111412, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Dec 26 18:13:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911036, encodeId=0fab91103687, content=学习学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Dec 26 09:56:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911028, encodeId=56e29110280f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201208/d1f232a1b61443dc893e8ff95474e60b/7ad7474277f6427eb1c2305a87e1c4b2.jpg, createdBy=1a665432979, createdName=Lydia-1110, createdTime=Sat Dec 26 09:19:31 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911012, encodeId=0deb911012b0, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Dec 26 07:53:31 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 Lydia-1110

    学习了

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1068460, encodeId=95f81068460c9, content=已拜读,受益匪浅。, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6c905475903, createdName=湘雅科教, createdTime=Tue Nov 09 10:26:24 CST 2021, time=2021-11-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2001177, encodeId=35b420011e777, content=<a href='/topic/show?id=d5df12695e6' target=_blank style='color:#2F92EE;'>#Neurol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12695, encryptionId=d5df12695e6, topicName=Neurol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8217292, createdName=yinhl1978, createdTime=Wed Feb 03 23:58:50 CST 2021, time=2021-02-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911176, encodeId=bd309111e61f, content=很好的文章<a href='/topic/show?id=23e3454e353' target=_blank style='color:#2F92EE;'>#学习#</a>学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=115, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45473, encryptionId=23e3454e353, topicName=学习)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201226/95ac6d022b194200b46211c8dd67d7d4/d7639abce33d42f18edacbf9c1818b2b.jpg, createdBy=1c242248512, createdName=医路顺丰, createdTime=Sat Dec 26 23:47:18 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911148, encodeId=9a3e91114865, content=REM睡眠行为障碍(REM sleep behavior disorder, RBD)的主要特点是容易做梦,而且这种做梦行为和正常肌肉松弛功能丧失密切相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=117, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzaiabIFicf63hKvVMjL6aJlx4yX4UcXmzX9DyibCRcicq0QtCRWMaQKh8MYjE1D3EKUBopgiaGWYuqbeR/0, createdBy=0c2b1999806, createdName=三生有幸9135, createdTime=Sat Dec 26 21:46:42 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911114, encodeId=71e691111412, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=00074131254, createdName=13c30453m58暂无昵称, createdTime=Sat Dec 26 18:13:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911036, encodeId=0fab91103687, content=学习学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKibA62IFMeUJEmSyIe8DvYFeERuOsfrRd8iano7nENqQU1dRR3tqeQOUL3eqgYgEZRT2t2iaEsib0JEw/132, createdBy=66771693911, createdName=易水河, createdTime=Sat Dec 26 09:56:41 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911028, encodeId=56e29110280f, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201208/d1f232a1b61443dc893e8ff95474e60b/7ad7474277f6427eb1c2305a87e1c4b2.jpg, createdBy=1a665432979, createdName=Lydia-1110, createdTime=Sat Dec 26 09:19:31 CST 2020, time=2020-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=911012, encodeId=0deb911012b0, content=好文章,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJlfgys76DEiaNtbYo2re3ibjrUPTRibEXRyFwAB4aAGiave842S0FQDf0wAoaH226NiaSoPPDzhndsf1g/132, createdBy=88b489038, createdName=yangchou, createdTime=Sat Dec 26 07:53:31 CST 2020, time=2020-12-26, status=1, ipAttribution=)]
    2020-12-26 yangchou

    好文章,谢谢分享。

    0

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