Diabetologia：维生素D缺乏与1型糖尿病

2012年11月16日 讯 /生物谷BIOON/ --近日，美国加州大学圣地亚哥医学院研究人员领导的一项研究发现血清维生素D3和1型糖尿病的发病率之间存在相关性。 这项近6年的研究，涉及了近2000人的血液样本。研究结果证实了维生素D3对糖尿病的预防作用。这一研究发表在十二月的Diabetologia杂志上。

以前的研究提出了维生素D缺乏和1型糖尿病之间的关联，但新研究首次证实了两者之间存在量效关系。

本研究分析了1000名1型糖尿病患者的血清样本，以及1000名健康对照者的血清样本。通过比较25-羟维生素D的血药浓度，研究人员能够确定了使得1型糖尿病的风险降低的最佳维生素D水平。这项研究的结果证实防止1型糖尿病发病的最佳浓度为50毫微克/毫升。

虽然有几个条件会影响维生素D的代谢，对于大多数人来说，每天补充4000IU的维生素D3就可以达到有效预防糖尿病发病的水平。

与糖尿病相关的拓展阅读：

• JAMA：研究支持对糖尿病患者进行更强力的抗血小板治疗
• Obes Surg：减重手术可能不能“治愈”糖尿病
• Cell Metab:新的血清标志物提前数年预测糖尿病风险
• Circulation：精氨酸酶抑制剂治疗糖尿病患者并发症
• JBC：维生素D或可抑制糖尿病患者动脉的阻塞 更多信息请点击：有关糖尿病更多资讯

Lower prediagnostic serum 25-hydroxyvitamin D concentration is associated with higher risk of insulin-requiring diabetes: a nested case–control study.

Aims/hypothesis   Low serum 25-hydroxyvitamin D [25(OH)D] concentration may increase risk of insulin-requiring diabetes.

Methods  A nested case–control study was performed using serum collected during 2002–2008 from military service members. One thousand subjects subsequently developed insulin-requiring diabetes. A healthy control was individually matched to each case on blood-draw date (±2 days), age (±3 months), length of service (±30 days) and sex. The median elapsed time between serum collection and first diagnosis of diabetes was 1 year (range 1 month to 10 years). Statistical analysis used matched pairs and conditional logistic regression.

Results   ORs for insulin-requiring diabetes by quintile of serum 25(OH)D, from lowest to highest, were 3.5 (95% CI 2.0, 6.0), 2.5 (1.5, 4.2), 0.8 (0.4, 1.4), 1.1 (0.6, 2.8) and 1.0 (reference) (p trend <0.001). The quintiles (based on fifths using serum 25(OH)D concentration in the controls) of serum 25(OH)D in nmol/l, were <43 (median 28), 43–59 (median 52), 60–77 (median 70), 78–99 (median 88) and ≥100 (median 128).

Conclusions/interpretation   Individuals with lower serum 25(OH)D concentrations had higher risk of insulin-requiring diabetes than those with higher concentrations. A 3.5-fold lower risk was associated with a serum 25(OH)D concentration ≥60 nmol/l.