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Med Oncol:乳腺癌脑转移的风险及预后评估

2014-12-06 MedSci译 MedSci原创

Med Oncol:乳腺癌脑转移的风险及预后评估 研究背景:乳腺癌一旦发生脑转移对于医生和患者来说是一个巨大挑战,脑转移患者有更差的预后,初诊后2年之内是发生脑转移的高峰期,已知的脑转移危险因素包括较小的年龄、低分化肿瘤、雌激素受体(ER)阴性或三阴性乳腺癌(TNBC)、HER2阳性。 研究目的:本文拟研究乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异。 研究方案:纳入人

研究背景:乳腺癌一旦发生脑转移对于医生和患者来说是一个巨大挑战,脑转移患者有更差的预后,初诊后2年之内是发生脑转移的高峰期,已知的脑转移危险因素包括较小的年龄、低分化肿瘤、雌激素受体(ER)阴性或三阴性乳腺癌(TNBC)、HER2阳性。 研究目的: 本文拟研究乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异。 研究方案: 纳入人群来源于德国滨根大学妇科部的80名脑转移患者,回顾性分析80名经治疗及随访的初诊无转移可手术的乳腺癌患者,治疗方式根据适应情况接受了赫赛汀及雌激素内分泌治疗,脑转移通过神经扫描仪诊断(neuro-scan CCT/MR),收集临床病理资料(初诊时分期、年龄、组织学级别、淋巴结状态、ER/PR/HER2状态、),记录经NMR/CCT发现脑转移的数量以及初诊至脑转移发生的时间,分析各种临床病理因素与预后的相关性,对资料的单因素及多因素分析使用PASW程序完成、生存曲线用Kaplan-Meier分析。 研究结果: 初诊时患者临床病理特征见table1,我们可以看出最常见的病理类型是组织学3级、浸润性导管癌。组织学3级、腋窝淋巴结转移、三阴性状态是发生

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1743535, encodeId=c1db1e43535bf, content=<a href='/topic/show?id=89691002006b' target=_blank style='color:#2F92EE;'>#预后评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100200, encryptionId=89691002006b, topicName=预后评估)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d4335139306, createdName=yeye5224624, createdTime=Sat Jul 04 18:10:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30076, encodeId=02f7300e67a, content=学习了,很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ecf497512, createdName=tzf419, createdTime=Tue Jun 30 23:18:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864568, encodeId=c6861864568cd, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Apr 30 19:10:00 CST 2015, time=2015-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13079, encodeId=383e130e9de, content=乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异分析挺到位的, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 18:05:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606344, encodeId=dd3c160634455, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Dec 08 04:10:00 CST 2014, time=2014-12-08, status=1, ipAttribution=)]
    2015-06-30 tzf419

    学习了,很有收获

    0

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    2015-04-30 minlingfeng
  4. [GetPortalCommentsPageByObjectIdResponse(id=1743535, encodeId=c1db1e43535bf, content=<a href='/topic/show?id=89691002006b' target=_blank style='color:#2F92EE;'>#预后评估#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=83, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100200, encryptionId=89691002006b, topicName=预后评估)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=6d4335139306, createdName=yeye5224624, createdTime=Sat Jul 04 18:10:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30076, encodeId=02f7300e67a, content=学习了,很有收获, beContent=null, objectType=article, channel=null, level=null, likeNumber=196, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ecf497512, createdName=tzf419, createdTime=Tue Jun 30 23:18:00 CST 2015, time=2015-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1864568, encodeId=c6861864568cd, content=<a href='/topic/show?id=16ce133504e' target=_blank style='color:#2F92EE;'>#Oncol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13350, encryptionId=16ce133504e, topicName=Oncol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b63894, createdName=minlingfeng, createdTime=Thu Apr 30 19:10:00 CST 2015, time=2015-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=13079, encodeId=383e130e9de, content=乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异分析挺到位的, beContent=null, objectType=article, channel=null, level=null, likeNumber=189, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=809381710, createdName=cbp, createdTime=Sat Dec 13 18:05:00 CST 2014, time=2014-12-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606344, encodeId=dd3c160634455, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Mon Dec 08 04:10:00 CST 2014, time=2014-12-08, status=1, ipAttribution=)]
    2014-12-13 cbp

    乳腺癌发生中枢神经系统(CNS)转移的危险因素以及脑转移后预后差异分析挺到位的

    0

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