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Ann Rheum Dis:原发性干燥综合征患者诊断性唇腺活检的生发中心不能预测腮腺MALT淋巴瘤发展

2017-07-15 xiangting MedSci原创

患腮腺MALT淋巴瘤的pSS患者与未发展为淋巴瘤的pSS患者,唇腺活检中的GCs没有差别。

原发性干燥综合征(pSS)患者发生非霍奇金淋巴瘤(NHL),特别是腮腺粘膜相关淋巴组织(MALT)淋巴瘤的风险增加。唇腺活检中存在生发中心(GCs)被认为是NHL的预测因子。这项研究评估了患腮腺MALT淋巴瘤(pSS中的主要NHL亚型)的pSS患者,与没有发展为淋巴瘤的pSS患者相比,唇腺活检中GCs是否增加。

将腮腺MALT淋巴瘤出现前取的pSS患者的11例唇腺活检与未发展成淋巴瘤的22例匹配的pSS对照组(1:2)进行比较。评估活检中的GCs(H&E和Bcl6)。

pSS MALT淋巴瘤患者的唇腺活检显示2/11(18%)H&E切片和3/11(27%)Bcl6染色切片中存在GCs。在对照组中,GCs存在于4/22(18%)H&E切片和5/22(23%)Bcl6染色切片中。

患腮腺MALT淋巴瘤的pSS患者与未发展为淋巴瘤的pSS患者,唇腺活检中的GCs没有差别。因此,唇腺活检中GCs的存在不是pSS相关性腮腺MALT淋巴瘤的预测因素。

原始出处:

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    2017-08-24 swallow
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    2017-07-23 shizhenshan
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createdBy=2aa512204505, createdName=dinorsor528, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222599, encodeId=dfe12225998f, content=学习新知识了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jul 15 14:12:34 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
  5. 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level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361498, encodeId=ab661361498d1, content=<a href='/topic/show?id=41828541441' target=_blank style='color:#2F92EE;'>#腮腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85414, encryptionId=41828541441, topicName=腮腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6411176, createdName=mfx799, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430890, encodeId=8e4b143089013, content=<a href='/topic/show?id=f9b9e9124a8' 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createdBy=2aa512204505, createdName=dinorsor528, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222599, encodeId=dfe12225998f, content=学习新知识了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jul 15 14:12:34 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
  6. 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level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1361498, encodeId=ab661361498d1, content=<a href='/topic/show?id=41828541441' target=_blank style='color:#2F92EE;'>#腮腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85414, encryptionId=41828541441, topicName=腮腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6411176, createdName=mfx799, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1430890, encodeId=8e4b143089013, content=<a href='/topic/show?id=f9b9e9124a8' target=_blank style='color:#2F92EE;'>#综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79124, encryptionId=f9b9e9124a8, topicName=综合征)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1531053, encodeId=b212153105376, content=<a href='/topic/show?id=06413e05695' target=_blank style='color:#2F92EE;'>#原发性干燥综合征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=37056, encryptionId=06413e05695, topicName=原发性干燥综合征)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2aa512204505, createdName=dinorsor528, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222599, encodeId=dfe12225998f, content=学习新知识了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jul 15 14:12:34 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-17 smlt2008
  7. 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createdBy=2aa512204505, createdName=dinorsor528, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222599, encodeId=dfe12225998f, content=学习新知识了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jul 15 14:12:34 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-17 mfx799
  8. 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  9. 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createdBy=2aa512204505, createdName=dinorsor528, createdTime=Mon Jul 17 02:55:00 CST 2017, time=2017-07-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=222599, encodeId=dfe12225998f, content=学习新知识了,谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jul 15 14:12:34 CST 2017, time=2017-07-15, status=1, ipAttribution=)]
    2017-07-15 flysky120

    学习新知识了,谢谢

    0

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目前,自身免疫性炎症和风湿免疫病仍然是医学界一个亟待攻克的难题,尽管医学家和研究者做了大量的努力和繁杂的科学实验,也取得了一些显而易见的成果,但对引起这类疾病的真正的环境因素尚不明确。这使我们想起了抗生素的发展历程:在明确抗生素的药理机制前,已经发现它数十年了。 因此,生活在21世纪的类风湿关节炎患者不像20世纪的大多数患者那样,有明确的疾病自然史。目前的治疗改变了这种不必要的疾病进程,

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