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Radiology:大环钆对比剂钆布醇MRI强化后齿状核中会残留!

2017-10-03 MedSci MedSci原创

本研究旨在验证原发颅脑肿瘤未行线性钆对比剂(GBCAs)但多次行大环钆对比剂增强检查后,在非强化T1加权磁共振(MR)图像上齿状核(DN)可测量的强化,并将结果发表在Radiology上。

本研究旨在验证原发颅脑肿瘤未行线性钆对比剂(GBCAs)但多次行大环钆对比剂增强检查后,在非强化T1加权磁共振(MR)图像上齿状核(DN)可测量的强化,并将结果发表在Radiology上。

本研究共纳入了17例高级别胶质瘤并行10-44次大环GBCA钆布醇(0.1 mmol/kg)增强扫描的患者。由两名神经放射学医师将TIWI图像调节至最佳窗宽窗位以便观察在基线和最后一次强化检查是DN强化信号的差异。DN的信号强度(SI)通过脑桥进行校准,利用单样本T检验分析基线时DN校准SI(nSI)(nSI DN)与基线后所有检查nSI DN 变化(ΔnSI DNavg)间的差异或基线与最后一次检查时nSI DN的差异。利用线性和二次相关分析检查大环GBCA注射和ΔnSI DN 或 ΔnSI DNavg的相关性。

结果为,大环GBCA注射次数的平均数±标准差为22.2 ± 10.6,历时706天± 454。在两例患者能够发现明显的信号强化,分别进行37、44次大环GBCA注射。平均ΔnSI DN要明显>0(0.03 ± 0.05; P = .016),在大环GBCA注射次数和ΔnSI DN (r = 0.69, P = .002) 、ΔnSI DNavg (r = 0.69, P = .002) and ΔnSI DNavg (r = 0.77, P < .001)间有显着的线性相关。

本研究表明,在行多册大环GBCA注射后,DN中会出现具有剂量依赖性信号强化,这种变化具有细小的统计学差异。有两名患者在分别行37、44次检查后出现明显的信号增强。

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    2017-10-03 清风拂面

    很好的文章.学习了

    0

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    2017-10-03 清风拂面

    谢谢分享.学习了

    0

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    2017-10-03 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

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