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Neurology:韩国轻中度饮酒可降低缺血性卒中的发生

2015-11-01 phylis 译 MedSci原创

目的:研究者进行了一项基于人群的病例对照研究,研究与西方酒精饮料偏好不同的韩国人在酒精摄入和缺血性卒中风险之间剂量反应关系,并且检测性别和缺血性卒中类型的影响。 方法:招募了年龄20岁以上首发卒中的患者1848名作为病例组。按照年龄(±3岁),性别及教育程度从第四和第五次韩国国家和营养调查中选取3589名无卒中的对照者与对照组进行配对。所有的受试者完成一项关于酒精摄入的结构性问卷调查的面谈。结果:

目的:研究者进行了一项基于人群的病例对照研究,研究与西方酒精饮料偏好不同的韩国人在酒精摄入和缺血性卒中风险之间的剂量反应关系,并且检测性别和缺血性卒中类型的影响。

方法:招募了年龄20岁以上首发卒中的患者1848名作为病例组。按照年龄(±3岁)、性别及教育程度从第四和第五次韩国国家和营养调查中选取3589名无卒中的对照者与对照组进行配对。所有的受试者完成一项关于酒精摄入的结构性问卷调查的面谈。

结果:校正潜在的混杂因素后,轻度到中度的酒精摄入(每天30到40g乙醇)与缺血性卒中发生的比率下降明显相关(无饮酒: 参考; <10g乙醇: OR 0.38, 95% CI 0.32-0.45; 10-20 g乙醇: 0.45, 0.36-0.57; 30-40g 酒精: 0.54, 0.39-0.74)。酒精对女性影响的阈值稍低于男性(女性10-20g乙醇 vs 男性30-40g乙醇),这种差异没有统计学意义。酒精摄入和缺血性卒中类型没有相关性。最常见的酒精饮料是一种原产于韩国的烧酒(78%的病例),酒精浓度为20%。

结论:在韩国,研究结果发现轻中度饮酒可能降低缺血性卒中的发生。

原文出处:

Lee SJ, Cho YJ, Kim JG,et al. Moderate alcohol intake reduces risk of ischemic stroke in Korea. Neurology.  2015,Oct 30


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    2016-05-27 yinhl1978
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