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Dig Liver Dis: 荟萃分析:抗TNFα药物是预防术后克罗恩病的更佳选择

2019-07-07 不详 MedSci原创

尽管克罗恩病(CD)的术后复发率(POR)很高,但其预防达策略还未达成共识。本项研究的目的是比较生物疗法和常规疗法在预防CD的POR方面的功效。

背景
尽管克罗恩病(CD)的术后复发率(POR)很高,但其预防达策略还未达成共识。本项研究的目的是比较生物疗法和常规疗法在预防CD的POR方面的功效。

方法
研究人员搜索所有的数据库查找了不同预防疗法对预防POR的文章。其检索策略是:(P)接受肠切除的CD成人,(I)生物制剂,(C)常规疗法或安慰剂,以及(O)临床,内窥镜和组织学POR。

结果
与传统疗法相比,抗TNFα药物在预防临床,内镜,严重内镜和组织学POR方面明显更好(P<0.05)。英夫利昔单抗和阿达木单抗在预防内镜下POR方面同样有效。

结论
即使在未经选择的CD患者中,抗-TNFα剂在预防临床,内窥镜和组织学POR方面也比常规疗法更有效。因此,推荐术后克罗恩病患者采用抗TNFα药物预防疾病复发。

原始出处:

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    2020-03-17 gongliu
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    2019-09-13 mfx808
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    2019-12-27 venlin
  5. [GetPortalCommentsPageByObjectIdResponse(id=1995762, encodeId=30cf1995e62f4, content=<a href='/topic/show?id=ba231e5989a' target=_blank style='color:#2F92EE;'>#TNFα#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17598, encryptionId=ba231e5989a, topicName=TNFα)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1a5a149, createdName=gongliu, createdTime=Tue Mar 17 23:15:00 CST 2020, time=2020-03-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1836942, encodeId=d1a0183694242, content=<a href='/topic/show?id=1f188e230c5' target=_blank style='color:#2F92EE;'>#荟萃分析#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87230, encryptionId=1f188e230c5, topicName=荟萃分析)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Sun Aug 04 15:15:00 CST 2019, time=2019-08-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1670780, encodeId=c33e16e07809b, content=<a href='/topic/show?id=abd35513ed5' target=_blank style='color:#2F92EE;'>#抗TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55137, encryptionId=abd35513ed5, topicName=抗TNF)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=7dc326754916, createdName=mfx808, createdTime=Fri Sep 13 23:15:00 CST 2019, time=2019-09-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1681380, encodeId=f59116813800d, content=<a href='/topic/show?id=366b8e2299e' target=_blank style='color:#2F92EE;'>#荟萃#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=87229, encryptionId=366b8e2299e, topicName=荟萃)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c12d27855367, createdName=venlin, createdTime=Fri Dec 27 01:15:00 CST 2019, time=2019-12-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2013047, encodeId=70fb201304e6a, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Wed Dec 18 01:15:00 CST 2019, time=2019-12-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1401729, encodeId=cc561401e293c, content=<a href='/topic/show?id=17e21e57943' target=_blank style='color:#2F92EE;'>#TNF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17579, encryptionId=17e21e57943, topicName=TNF)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eqjVbfRD4f4vibEcZVcvato8Qib1gGtZJiayXCMFgHrkeErSiaxdYMiabKGxY2an9muxWCkUJbjFPViaC6A/132, createdBy=e4fb2361580, createdName=snowpeakxu, createdTime=Tue Jul 09 11:15:00 CST 2019, time=2019-07-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369273, encodeId=ed5d3692e37e, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=132, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Mon Jul 08 06:48:36 CST 2019, time=2019-07-08, status=1, ipAttribution=)]
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    2019-07-09 snowpeakxu
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    2019-07-08 130****4638

    学习了,谢谢分享。

    0

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