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J Rheumatol:幼年特发性关节炎的纵向健康状况和相关预后因素

2019-03-28 xiangting MedSci原创

JIA患者在随访3年和19年后的躯体功能、健康和疼痛相似。19年后患者的健康状况也比对照组差。

这项研究旨在描述幼年特发性关节炎(JIA)患者从儿童期到成年的纵向健康状况,在19年后与对照组进行结局比较,并确定躯体功能、疼痛和躯体健康相关生活质量(HRQOL)的早期预测因子。

1995-2003年间,96名JIA患者(平均6.1±4.0岁,67%为女性)在诊断后18个月内和此后3年每6个月进行一次JIA疾病活动性指标、躯体功能、疼痛、疲劳和健康评估。平均18.9±1.5年后(平均年龄25.1±4.2岁)进行重新评估,测量身体残疾(HAQ)、疼痛、疲劳、健康(VAS)以及身心HRQOL(S-12)。

最初3年内,身体残疾得到改善(p<0.001),报告最佳健康状况的患者比例升高(p=0.013),而疼痛和疲劳没有改变。在3年和19年的随访中,患者的身体残疾、健康和疼痛水平相似,但疲劳增多(p=0.016),HAQ=0的患者数量减少(p=0.001)。19年后,患者的疼痛和躯体HRQOL比对照组差(p<0.001)。最初3年内的疼痛、活动性关节和身体残疾与19年后更多的残疾、疼痛以及更差的躯体HRQOL相关(p<0.001-0.047)。

JIA患者在随访3年和19年后的躯体功能、健康和疼痛相似,但19年后的疲劳更常见。19年后患者的健康状况也比对照组差。疼痛、活动性关节和身体残疾是不良结局的早期预测因素。

原始出处:

Anita Tollisen. Longitudinal health status from early disease to adulthood and associated prognostic factors in juvenile idiopathic arthritis. J Rheumatol. 15 March 2019.

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