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Clin Gastroenterology H: 2型糖尿病患者病情缓解程度与超声检查中的脂肪肝严重程度城负相关

2021-02-28 MedSci原创 MedSci原创

全球2型糖尿病(T2D)的患病率正在逐年上升,2015年,国际糖尿病联合会预测全球有4.15亿成年人患有T2D,并且有500万人死于T2D

      全球2型糖尿病(T2D)的患病率正在逐年上升,2015年,国际糖尿病联合会(International Diabetes Federation)预测全球有4.15亿成年人患有T2D,并且有500万人死于T2D。T2D通常被认为是渐进的和不可逆的,但是T2D病情的缓解是可能的。T2D缓解通常是指在没有积极抗糖尿病治疗的情况下,维持T2D患者的非糖尿病水平的空腹血糖(FPG)和血红蛋白A 1c(HbA 1c)水平再正常水平。脂肪肝(FL)是人群中最常见的肝脏疾病。在一半以上的T2D患者中,通过超声检查可以发现FL的普遍存在,FL可通过增加肝胰岛素抵抗和肝葡萄糖产生而增加T2D的风险。FL可能还会干扰T2D缓解,减少肝脏中的脂肪含量可能会促进T2D缓解。但是,目前尚无关于脂肪肝的改善是否能减少2型糖尿病缓解的证据。因此,本项研究旨在探究脂肪肝与2型糖尿病缓解之间的关联。

 

 

      研究人员收集了2008年至2016年间在日本一个医疗中心进行过2型糖尿病筛查的66961人的数据。初步分析纳入了2567例无慢性肾功能衰竭或有血液透析病史的2型糖尿病患者,所有患者均接受了超声检查以检测脂肪肝的程度,所有患者均接受了基线超声检查后平均24.5个月的随访检查,包括血液检查。2型糖尿病的缓解被定义为空腹血糖水平低于126 mg/dL,HbA1c水平低于6.5%,同时持续6个月以上而未使用抗糖尿病药物。

 

 

      在随访期间,通过超声检查发现脂肪肝的患者在随访期间患上2型糖尿病的比例低于没有脂肪肝的患者(8.7%,167/1910 VS 13.1%,86/657)。基线脂肪肝与2型糖尿病的缓解几率较低相关(OR:0.51; 95%CI:0.37-0.72)。脂肪肝改善的患者中2型糖尿病的缓解率高于脂肪肝无改善的患者(21.1%,32/152 VS 7.7%,129/1681)。脂肪肝的改善与2型糖尿病的缓解几率更高(OR,3.08; 95%CI,1.94-4.88)。

 

 

      本项研究发现在2年的随访期内,通过超声检查发现脂肪肝患者中2型糖尿病的缓解并不常见,但是脂肪肝的改善与2型糖尿病的缓解独立相关。

 

 

原始出处:

Hajime Yamazaki. Et al. Inverse Association Between Fatty Liver at Baseline Ultrasonography and Remission of Type 2 Diabetes Over a 2-Year Follow-up Period. Clinical Gastroenterology and Hepatology.2021.

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    2021-10-03 许安
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  5. 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topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Tue Mar 02 11:27:33 CST 2021, time=2021-03-02, status=1, ipAttribution=)]
    2021-03-07 ms3000000884376020

    学习

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2073260, encodeId=7c0420e32604b, content=<a href='/topic/show?id=9d4ee84647' target=_blank style='color:#2F92EE;'>#GAS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7846, encryptionId=9d4ee84647, topicName=GAS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e2dd327, createdName=许安, createdTime=Sun Oct 03 16:27:33 CST 2021, time=2021-10-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2065284, encodeId=90b72065284d6, content=<a href='/topic/show?id=94ffe853a7' target=_blank style='color:#2F92EE;'>#Gastroenterol#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7853, encryptionId=94ffe853a7, topicName=Gastroenterol)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0bed488, 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createdTime=Sun Mar 07 12:02:48 CST 2021, time=2021-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=944749, encodeId=d1d3944e49cf, content=糖尿病病情的缓解成都与脂肪肝的严重程度呈负相关, beContent=null, objectType=article, channel=null, level=null, likeNumber=142, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210110/e6124a4b19bc40ce8afaae096d21126b/dd778ac260c9416eb87e7d08139507f5.jpg, createdBy=4d2f5079605, createdName=科研科研科研, createdTime=Tue Mar 02 12:48:06 CST 2021, time=2021-03-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1284320, encodeId=726a1284320cd, content=<a href='/topic/show?id=d27a9280461' target=_blank style='color:#2F92EE;'>#超声检查#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=93, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=92804, encryptionId=d27a9280461, topicName=超声检查)], attachment=null, 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    2021-03-07 ms3000000884376020

    学习

    0

  7. 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    2021-03-02 科研科研科研

    糖尿病病情的缓解成都与脂肪肝的严重程度呈负相关

    0

  8. 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