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单细胞转录组研究进展

2014-01-03 周超平 李鑫辉 生物化学与生物物理学进展

转录组单细胞转录组
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   单细胞转录组分析以单个细胞为特定研究对象，提取mRNA进行逆转录、放大和高通量测序分析，能揭示该细 胞内整体水平的基因表达状态和基因结构信息，准确反映细胞间的异质性，深入理解其基因型和表型之间的相互关系，在发育生物学、基础医学、临床诊断和药物开 发等领域都发挥重要作用．本文主要介绍了单细胞转录组分析的特点和技术发展历史以及常用研究策略和不同技术的优缺点，并就其面临挑战

   单细胞转录组分析以单个细胞为特定研究对象，提取mRNA进行逆转录、放大和高通量测序分析，能揭示该细 胞内整体水平的基因表达状态和基因结构信息，准确反映细胞间的异质性，深入理解其基因型和表型之间的相互关系，在发育生物学、基础医学、临床诊断和药物开 发等领域都发挥重要作用．本文主要介绍了单细胞转录组分析的特点和技术发展历史以及常用研究策略和不同技术的优缺点，并就其面临挑战和未来发展前景进行了 讨论，为该技术的进一步研究与应用提供参考．单细胞转录组研究进展.pdf

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    2014-12-04 mjldent

    #转录#

    0

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    2014-07-15 ms1774076774505970

    #转录组研究#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1747175, encodeId=74d31e4717562, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Thu Dec 04 22:50:00 CST 2014, time=2014-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813651, encodeId=7aad181365120, content=<a href='/topic/show?id=dc07933e5fc' target=_blank style='color:#2F92EE;'>#转录组研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93375, encryptionId=dc07933e5fc, topicName=转录组研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e62500168, createdName=ms1774076774505970, createdTime=Tue Jul 15 05:50:00 CST 2014, time=2014-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380399, encodeId=f4aa1380399ea, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420156, encodeId=f4b6142015627, content=<a href='/topic/show?id=5f3a9336904' target=_blank style='color:#2F92EE;'>#转录组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93369, encryptionId=5f3a9336904, topicName=转录组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c9e3571203, createdName=marlenexl, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 mashirong

    #研究进展#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1747175, encodeId=74d31e4717562, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Thu Dec 04 22:50:00 CST 2014, time=2014-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813651, encodeId=7aad181365120, content=<a href='/topic/show?id=dc07933e5fc' target=_blank style='color:#2F92EE;'>#转录组研究#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93375, encryptionId=dc07933e5fc, topicName=转录组研究)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=47e62500168, createdName=ms1774076774505970, createdTime=Tue Jul 15 05:50:00 CST 2014, time=2014-07-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1380399, encodeId=f4aa1380399ea, content=<a href='/topic/show?id=9281e34519b' target=_blank style='color:#2F92EE;'>#研究进展#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=73451, encryptionId=9281e34519b, topicName=研究进展)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f13d475, createdName=mashirong, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1420156, encodeId=f4b6142015627, content=<a href='/topic/show?id=5f3a9336904' target=_blank style='color:#2F92EE;'>#转录组#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=69, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93369, encryptionId=5f3a9336904, topicName=转录组)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2c9e3571203, createdName=marlenexl, createdTime=Sun Jan 05 12:50:00 CST 2014, time=2014-01-05, status=1, ipAttribution=)]
    2014-01-05 marlenexl

    #转录组#

    0

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