JCEM：低血糖对糖尿病患者循环干细胞和祖细胞的影响！

2017-12-30 xing.T MedSci原创

在糖尿病患者中，单一轻度的低血糖发作可损害生理性EPC波动，而严重的低血糖可显著减少干细胞和内皮祖细胞。这些数据为低血糖和糖尿病不良后果之间提供了一种新的可能联系。

医源性低血糖症是糖尿病最常见的急性并发症，其发病率明显增加。在糖尿病患者中，循环中干细胞和祖细胞水平的降低预示着预后不良。近日，内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章，研究人员旨在探讨糖尿病患者的低血糖是否会影响循环干细胞和内皮祖细胞（EPCs）。

研究人员进行了一项实验性低血糖研究（研究1）和一项病例对照研究（研究2）。研究1的参与者为1型糖尿病患者（n=19）；研究2的参与者为糖尿病患者住院治疗期间发生严重的医源性低血糖患者和匹配的住院、门诊的对照者（n=22）。1型糖尿病患者在早餐时随机诱导和未诱导低血糖期间接受两轮的住院血糖监测。在研究2中，研究人员比较了住院低血糖患者与匹配的对照者。该研究的主要指标未通过流式细胞仪检测的基于CD34和KDR表达的循环干细胞和EPCs水平。

在研究1中，CD34+KDR+EPCs从上午8点到下午2点的生理衰退可被胰岛素诱导的1型糖尿病患者低血糖所消除。在研究2中，住院治疗严重医源性低血糖的糖尿病患者CD34+干细胞和CD34+KDR+EPCs水平明显低于住院或门诊的糖尿病对照者。

在糖尿病患者中，单一轻度的低血糖发作可损害生理性EPC波动，而严重的低血糖可显著减少干细胞和内皮祖细胞。这些数据为低血糖和糖尿病不良后果之间提供了一种新的可能联系。

原始出处：

Gian Paolo Fadini,et al. Effects of hypoglycaemia on circulating stem and progenitor cells in diabetic patients.J Clin Endocrinol Metab. 2017. https://doi.org/10.1210/jc.2017-02187

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2018-02-26 achengzhao

#JCE#

63 0
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2018-06-09 smallant2015

#JCEM#

67 0
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2018-01-04 wzb521zf

一起学习学习

105 0
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2018-01-01 雅文博武

学习了很多先进水平

84 0
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2018-01-01 xue8604

#糖尿病患者#

64 0
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2018-01-01 12498636m52(暂无昵称)

#祖细胞#

59 0

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JCEM：低血糖对糖尿病患者循环干细胞和祖细胞的影响！

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