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PLoS Pathog:重新定义幽门螺杆菌脂多糖O-抗原和核心寡糖结构域

2017-03-25 MedSci MedSci原创

细菌病原体幽门螺杆菌能够长期感染人类胃部并引起溃疡和胃癌。幽门螺杆菌脂多糖可以通过免疫逃避促进持续感染。尽管确认了幽门螺杆菌脂多糖在发病机制中的关键作用。但是其精确的结构域组织结构仍然未知。

最近,来自美国西北大学费恩伯格医学院的研究人员报道了一项关于幽门螺杆菌脂多糖O-抗原和核心寡糖结构域的研究, 相关研究刊登于国际杂志PLoS Pathog上。

细菌病原体幽门螺杆菌能够长期感染人类胃部并引起溃疡和胃癌。幽门螺杆菌脂多糖可以通过免疫逃避促进持续感染。尽管确认了幽门螺杆菌脂多糖在发病机制中的关键作用。但是其精确的结构域组织结构仍然未知。

研究人员使用生物化学,遗传学和分析化学多学科的方法,阐明了幽门螺杆菌脂多糖结构和结构域。研究人员发现其核心结构域是一个短的保守的六糖,缺乏规范的内外核心组织。O-抗原围绕以前被认定为外核结构域的结构域,起始于保守的三糖可变葡聚糖和庚糖部分,终止于Lewis抗原。

此外,研究人员还证明O抗原的核心结构域和保守的三糖的完整性对幽门螺杆菌定殖于胃基底是非常关键的。同时,重新定义幽门螺杆菌脂多糖结构域要求未来的研究,应该聚焦其在宿主病原体相互作用和持久性中的作用。参与组装保守结构的酶也可能是设计用于控制持续感染幽门螺旋杆菌的新的治疗药物。

原始出处:

Hong Li, Tiandi Yang, Tingting Liao. et al.The redefinition of Helicobacter pylori lipopolysaccharide O-antigen and core-oligosaccharide domains. Published: March 17, 2017http://dx.doi.org/10.1371/journal.ppat.1006280

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    2017-09-22 gjsgj
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    2017-10-28 kcb069
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