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JCLA：在资源有限的实验室中，细胞群数据(VCS参数)作为急性髓系白血病(AML)的快速筛选工具的实用性如何？

2019-06-06 gladiator 梅斯原创

快速筛选
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尽管诊断技术近年来有了长足的发展，但在没有配备检测设备的偏远地区许多急性髓性白血病(AML)病例仍未得到充分诊断。我们在此提出假设，带有散点图和标记的自动化细胞指数可能有助于快速有效地筛查AML。 研究人员采用Coulter LH 780自动分析仪对100个新生AML样本的细胞群数据(CPD)参数进行分析，并与100个年龄匹配的对照组进行比较。参数也分别与100例中性粒细胞增多症和50例单核

尽管诊断技术近年来有了长足的发展，但在没有配备检测设备的偏远地区许多急性髓性白血病(AML)病例仍未得到充分诊断。我们在此提出假设，带有散点图和标记的自动化细胞指数可能有助于快速有效地筛查AML。

研究人员采用Coulter LH 780自动分析仪对100个新生AML样本的细胞群数据(CPD)参数进行分析，并与100个年龄匹配的对照组进行比较。参数也分别与100例中性粒细胞增多症和50例单核细胞增多症的反应性病例进行了比较。同时，系统‐生成的标志和散点图模式也进行了分析。

通过比较AML病例和正常对照组; AML FAB M2，M3，M4与反应性中性白细胞增多症; 以及AML FAB M4，M5与反应性单核细胞增多症。从所有比较组中选择重要参数。使用适当的统计工具，计算这些参数的截止值，并能够筛选出具有94％灵敏度和95％特异性的AML病例。使用两个最重要的参数产生三个统计方程，其将灵敏度提高至98％，特异性提高至99％。设计了五种假设的散点图模式，并根据AML的FAB类别进行分类。最常见的模式是在AML中选择的，56％的病例中都有这种模式。结合这些模式和标志与CPD参数分析输出。无论是单独的CPD，还是以统计方程的形式，以及散点图和标记，都可以为AML的初步诊断提供快速和经济的工具。

原始出处：

Harpreet Virk, Neelam Varma, Utility of cell population data (VCS parameters) as a rapid screening tool for Acute Myeloid Leukemia (AML) in resource‐constrained laboratories

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    2020-04-18 lidong40

    #实用性#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2069701, encodeId=dedf2069e01b9, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Apr 18 14:08:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822091, encodeId=8f761822091b1, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Aug 08 01:08:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368364, encodeId=c71436836476, content=思路可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eplE0ibU6ibojd8kldo3Cwhz7J5SP84VgZDUp1EHRWUBcM1QhpLZDfg6Leicuur1ENOctnNcHuGe7ppg/132, createdBy=ace52434990, createdName=158C71s1656, createdTime=Wed Jun 26 06:02:30 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584422, encodeId=b83d1584422fd, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sat Jun 08 14:08:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367388, encodeId=a76136e388f8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 06 23:52:41 CST 2019, time=2019-06-06, status=1, ipAttribution=)]
    2019-08-08 fangcong

    #髓系白血病#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2069701, encodeId=dedf2069e01b9, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Apr 18 14:08:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822091, encodeId=8f761822091b1, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Aug 08 01:08:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368364, encodeId=c71436836476, content=思路可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eplE0ibU6ibojd8kldo3Cwhz7J5SP84VgZDUp1EHRWUBcM1QhpLZDfg6Leicuur1ENOctnNcHuGe7ppg/132, createdBy=ace52434990, createdName=158C71s1656, createdTime=Wed Jun 26 06:02:30 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584422, encodeId=b83d1584422fd, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sat Jun 08 14:08:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367388, encodeId=a76136e388f8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 06 23:52:41 CST 2019, time=2019-06-06, status=1, ipAttribution=)]
    2019-06-26 158C71s1656

    思路可以借鉴

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=2069701, encodeId=dedf2069e01b9, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Apr 18 14:08:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822091, encodeId=8f761822091b1, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Aug 08 01:08:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368364, encodeId=c71436836476, content=思路可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eplE0ibU6ibojd8kldo3Cwhz7J5SP84VgZDUp1EHRWUBcM1QhpLZDfg6Leicuur1ENOctnNcHuGe7ppg/132, createdBy=ace52434990, createdName=158C71s1656, createdTime=Wed Jun 26 06:02:30 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584422, encodeId=b83d1584422fd, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sat Jun 08 14:08:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367388, encodeId=a76136e388f8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 06 23:52:41 CST 2019, time=2019-06-06, status=1, ipAttribution=)]
    2019-06-08 ms6747015003810650

    #筛选#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=2069701, encodeId=dedf2069e01b9, content=<a href='/topic/show?id=ebbc4606222' target=_blank style='color:#2F92EE;'>#实用性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46062, encryptionId=ebbc4606222, topicName=实用性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6da1120, createdName=lidong40, createdTime=Sat Apr 18 14:08:00 CST 2020, time=2020-04-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822091, encodeId=8f761822091b1, content=<a href='/topic/show?id=ee4b1021266e' target=_blank style='color:#2F92EE;'>#髓系白血病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102126, encryptionId=ee4b1021266e, topicName=髓系白血病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b79433, createdName=fangcong, createdTime=Thu Aug 08 01:08:00 CST 2019, time=2019-08-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=368364, encodeId=c71436836476, content=思路可以借鉴, beContent=null, objectType=article, channel=null, level=null, likeNumber=102, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eplE0ibU6ibojd8kldo3Cwhz7J5SP84VgZDUp1EHRWUBcM1QhpLZDfg6Leicuur1ENOctnNcHuGe7ppg/132, createdBy=ace52434990, createdName=158C71s1656, createdTime=Wed Jun 26 06:02:30 CST 2019, time=2019-06-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584422, encodeId=b83d1584422fd, content=<a href='/topic/show?id=9bbee5948f0' target=_blank style='color:#2F92EE;'>#筛选#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=75948, encryptionId=9bbee5948f0, topicName=筛选)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=39da17047364, createdName=ms6747015003810650, createdTime=Sat Jun 08 14:08:00 CST 2019, time=2019-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=367388, encodeId=a76136e388f8, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jun 06 23:52:41 CST 2019, time=2019-06-06, status=1, ipAttribution=)]
    2019-06-06 orangesking

    好

    0

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