Baidu
map

急性骨髓炎抗生素静脉改口服时间点

2014-01-29 cmt 医学论坛网

急性骨髓炎通常会诱发严重的临床后果,重者可能会至患儿死亡,为减少这种可能性,临床上在急性骨髓炎患儿治疗早期应用静脉抗生素治疗,在患儿接近康复时转为口服抗生素。但很少有临床医生意识到,在1930年末期口服磺胺类抗生素就可以有效的治疗急性骨髓炎患者。 近些年抗生素的种类及抗菌谱得到了极大的发展,其治疗策略也发生了重大变化,静脉使用抗生素治疗急性骨髓炎已经成为一种临床习惯,但参考数十年前的抗生素治

急性骨髓炎通常会诱发严重的临床后果,重者可能会至患儿死亡,为减少这种可能性,临床上在急性骨髓炎患儿治疗早期应用静脉抗生素治疗,在患儿接近康复时转为口服抗生素。但很少有临床医生意识到,在1930年末期口服磺胺类抗生素就可以有效的治疗急性骨髓炎患者。

近些年抗生素的种类及抗菌谱得到了极大的发展,其治疗策略也发生了重大变化,静脉使用抗生素治疗急性骨髓炎已经成为一种临床习惯,但参考数十年前的抗生素治疗策略,治疗早期即开始口服抗生素并不会产生不良后果。问题是,早期口服的早期时间点在哪。

目前有三个研究证明,对急性骨髓炎患者,静脉抗生素使用持续小于1周并不会显著改变临床功能预后。一项英国完成的系统回顾发现,短期肠道外给药治疗无并发症的骨髓炎疗效可靠。作者对131例免疫完整的年龄大于3月的患儿治疗中发现,静脉治疗2-4天,后改为口服治疗,骨髓炎后期无明显复发。但是该结论对MRSA患者不适用。对MRSA感染较为严重的地区,如美国,更加保守的抗生素治疗策略可能相对合适,但需要后期临床研究进一步明确。


版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (3)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1975947, encodeId=81ff19e594736, content=<a href='/topic/show?id=5b3d524e76a' target=_blank style='color:#2F92EE;'>#急性骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52477, encryptionId=5b3d524e76a, topicName=急性骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Dec 19 09:29:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697194, encodeId=741f169e1943b, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Jun 27 05:29:00 CST 2014, time=2014-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374585, encodeId=fbe713e458570, content=<a href='/topic/show?id=cade101985bd' target=_blank style='color:#2F92EE;'>#骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101985, encryptionId=cade101985bd, topicName=骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Jan 31 04:29:00 CST 2014, time=2014-01-31, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1975947, encodeId=81ff19e594736, content=<a href='/topic/show?id=5b3d524e76a' target=_blank style='color:#2F92EE;'>#急性骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52477, encryptionId=5b3d524e76a, topicName=急性骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Dec 19 09:29:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697194, encodeId=741f169e1943b, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Jun 27 05:29:00 CST 2014, time=2014-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374585, encodeId=fbe713e458570, content=<a href='/topic/show?id=cade101985bd' target=_blank style='color:#2F92EE;'>#骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101985, encryptionId=cade101985bd, topicName=骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Jan 31 04:29:00 CST 2014, time=2014-01-31, status=1, ipAttribution=)]
    2014-06-27 fusion
  3. [GetPortalCommentsPageByObjectIdResponse(id=1975947, encodeId=81ff19e594736, content=<a href='/topic/show?id=5b3d524e76a' target=_blank style='color:#2F92EE;'>#急性骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=73, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=52477, encryptionId=5b3d524e76a, topicName=急性骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Dec 19 09:29:00 CST 2014, time=2014-12-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1697194, encodeId=741f169e1943b, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Fri Jun 27 05:29:00 CST 2014, time=2014-06-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1374585, encodeId=fbe713e458570, content=<a href='/topic/show?id=cade101985bd' target=_blank style='color:#2F92EE;'>#骨髓炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=98, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101985, encryptionId=cade101985bd, topicName=骨髓炎)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6105386, createdName=宋威, createdTime=Fri Jan 31 04:29:00 CST 2014, time=2014-01-31, status=1, ipAttribution=)]
    2014-01-31 宋威
Baidu
map
Baidu
map
Baidu
map