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J Mech Behav Biomed Mater:金属离子掺杂的磷酸三钙陶瓷:动态负载对体内骨再生的影响

2019-10-29 不详 网络

本研究旨在评估动态负载对不同掺杂的β-三钙磷酸钙陶瓷骨再生性能的影响。通过水溶液燃烧技术开发了多孔β-磷酸三钙(β-TCP),5%锌掺杂,5%镁掺杂和5%钛掺杂β-TCP。所有合成的β-TCP粉末的孔径分别为21-146μm(纯β-TCP),16-142μm(Zn-β-TCP),28-156μm(Mg-β-TCP)和14-173μm (Ti-β-TCP)的表观孔隙率分别为17.89%,28.09%

本研究旨在评估动态负载对不同掺杂的β-三钙磷酸钙陶瓷骨再生性能的影响。

通过水溶液燃烧技术开发了多孔β-磷酸三钙(β-TCP),5%锌掺杂,5%镁掺杂和5%钛掺杂β-TCP。所有合成的β-TCP粉末的孔径分别为21-146μm(纯β-TCP),16-142μm(Zn-β-TCP),28-156μm(Mg-β-TCP)和14-173μm (Ti-β-TCP)的表观孔隙率分别为17.89%,28.09%,26.54%和25.87%。将纯净和掺杂的样品植入股骨缺损模型(兔子)中,以评估动态载荷下的骨再生。植入后1和2个月,根据临床放射学,组织学,荧光染料标记,显微计算机断层扫描(μ-CT)和扫描电子显微镜(SEM)评估骨再生。

放射学和荧光染料标记研究表明,与其他组相比,相对于更多的新骨形成而言,减少了5%Ti-β-TCP植入物的尺寸。与其他样品相比,植入骨样品的Micro-CT显示在Ti-β-TCP植入物周围有大量新形成的骨组织。在SEM研究中也观察到了类似的发现,即植入物与骨骼之间的界面间隙较小。但是,所有掺杂的材料都适合作为骨移植材料,并具有在骨组织工程中应用的潜力。

原始出处:

Samanta SK, Devi KB, et al., Metallic ion doped tri-calcium phosphate ceramics: Effect of dynamic loading on in vivo bone regeneration. J Mech Behav Biomed Mater. 2019 Aug;96:227-235. doi: 10.1016/j.jmbbm.2019.04.051. Epub 2019 Apr 26.

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    2020-03-31 redcrab
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    2020-07-01 sunylz
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    2019-10-31 lsj630
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    2019-10-31 qjddjq
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    2019-10-30 一天没事干

    很好的学习机会

    0

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