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Int J Mol Sci:干细胞疗法治疗眼部微生物感染的

2018-02-21 cuiguizhong MedSci原创

马来西亚太子大学生物医学系的Teh SW近日在Int J Mol Sci发表了一篇综述,系统性的回顾了影响眼睛的常见传染因子,其中包括真菌、病毒、寄生虫和细菌,目的是讨论当前抗菌治疗的挑战。

马来西亚太子大学生物医学系的Teh SW近日在Int J Mol Sci发表了一篇综述,系统性的回顾了影响眼睛的常见传染因子,其中包括真菌、病毒、寄生虫和细菌,目的是讨论当前抗菌治疗的挑战。

在过去的二十年中,眼部微生物感染已经成为一个重大的公共卫生问题。有多种致病因素会引起眼部微生物的感染,其特征在于眼组织出现持续性和破坏性的炎症、进行性视力障碍,有一些如果没有得到早期有效的治疗,可能会导致患者失明。

治疗由微生物感染引起的视力损伤和失明的常规治疗方法包括:以消除有害病原体为目标的抗生素疗法;或在严重情况下,通过手术和视网膜移植替换感染区的手术治疗方法。在炎症发生的情况下,一旦感染得到控制,抗炎症药物可以减少炎症引起的眼部损伤。尽管医学研究取得巨大的进展,但控制眼部微生物感染的进展仍然发展缓慢。

不同个体眼部组织恢复呈现不同的程度和不完整的视觉功能恢复,这表明当前的治疗策略存在局限性。需要开发更广泛的疗法来帮助恢复患者的视力。干细胞是多能性的基质细胞,可以根据适当的分化方案产生各种各样的细胞类型。干细胞治疗有望通过调节免疫反应促进组织再生,从而减轻炎症反应,并修复由微生物感染引起的眼部组织损伤。本文系统性的回顾了影响眼睛的常见传染因子,其中包括真菌、病毒、寄生虫和细菌,目的是讨论当前抗菌治疗的挑战。他们还讨论了关于脓毒症治疗的干细胞研究进展的现状,作者认为可以作为眼部微生物感染治疗的最佳方案。

原文出处:

Teh, S.W., et al., Recent Updates on Treatment of Ocular Microbial Infections by Stem Cell Therapy: A Review. Int J Mol Sci, 2018. 19(2).

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

 

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    2018-09-21 huiwelcome
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    2018-02-21 清风拂面

    谢谢分享学习

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    2018-02-21 医者仁心5538

    学习了

    0

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