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J Periodontol:Omega-3 PUFA和阿司匹林可作为牙周炎和2型糖尿病患者牙周清创术的辅助治疗手段

2021-01-30 MedSci原创 MedSci原创

有学者提出将补充ω-3多不饱和脂肪酸(ω-3 PUFA)和低剂量阿司匹林(ASA)作为控制慢性炎症性疾病的宿主调节方案,尚缺乏高质量的临床研究加以证实。近期,发表于J Peri

有学者提出将补充ω-3多不饱和脂肪酸(ω-3 PUFA)和低剂量阿司匹林(ASA)作为控制慢性炎症性疾病的宿主调节方案,尚缺乏高质量的临床研究加以证实。近期,发表于J Periodontol的一项研究探讨了口服ω-3 PUFA和ASA作为辅助手段治疗伴有2型糖尿病的牙周炎患者刮治治疗后的临床和免疫学影响。

研究纳入75名患者作为研究对象。随机分为3组,分别接受安慰剂和牙周清创(CG),以及牙周清创后接受ω-3 PUFA+ASA(3 g鱼油/d+100 mg ASA/d,2个月)(试验组[TG]1),或牙周清创前接受ω-3 PUFA+ASA(3 g鱼油/d+100 mg ASA/d,2个月)(TG2)。基线以及治疗后3和6个月手机牙周参数和GCF。

 

结果显示,TG1中10名患者(40%)和TG2中9名患者(36%)达到了治疗的临床终点(探诊深度≥5mm的部位≤4个),而CG中只有4名(16%)。TG1探诊深度中和深的点均出现临床附着水平的增加。两个试验组的IFN-γ和白细胞介素(IL)-8水平均随时间下降。TG1的IL-6水平较低。TG1的HbA1c水平降低。

综上所述,该研究结果表明,牙周刮治后辅助ω-3和ASA对2型糖尿病患者牙周炎的治疗具有临床和免疫学的有益意义。

 

原始出处:

 

Nidia C Castro Dos Santos, Naira M R B Andere, et al., Omega-3 PUFA and aspirin as adjuncts to periodontal debridement in patients with periodontitis and type 2 diabetes mellitus: Randomized clinical trial. J Periodontol. 2020 Oct;91(10):1318-1327. doi: 10.1002/JPER.19-0613.

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    2021-05-09 lingaifan
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    2021-09-20 feather89
  4. 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createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/FGFAawy0kQNXbuvUuLtUVrx5aKhOIkwqJwyxu0QlpLFIDSb1Ht19ptXvYBjuAoNBubibnNF3iazdpico7gJlbBVQg/132, createdBy=edaf2500125, createdName=ms3892185887221420, createdTime=Sun Sep 26 16:02:43 CST 2021, time=2021-09-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1728805, encodeId=a1441e2880510, content=<a href='/topic/show?id=986913980dd' target=_blank style='color:#2F92EE;'>#PE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13980, encryptionId=986913980dd, topicName=PE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f06c33759375, createdName=feather89, createdTime=Mon Sep 20 21:02:43 CST 2021, time=2021-09-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=925532, encodeId=8213925532f0, content=好文章, beContent=null, objectType=article, channel=null, level=null, 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href='/topic/show?id=196a1101f7' target=_blank style='color:#2F92EE;'>#2型糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1101, encryptionId=196a1101f7, topicName=2型糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec19483, createdName=aids213, createdTime=Mon Feb 01 13:02:43 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1451345, encodeId=ee601451345cc, content=<a href='/topic/show?id=f0476e49582' target=_blank style='color:#2F92EE;'>#牙周#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=75, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67495, encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=医者仁心, createdTime=Mon Feb 01 13:02:43 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475034, encodeId=f0c614e50344a, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Feb 01 13:02:43 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921662, encodeId=a3c392166294, content=学海无涯苦作舟!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287c2410703, createdName=Jason20042008, createdTime=Sun Jan 31 12:59:28 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921556, encodeId=9f1492155611, content=融合学科, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sun Jan 31 07:14:25 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
    2021-02-19 carrotlyl

    好文章

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1700973, encodeId=8bdc1e00973ef, content=<a href='/topic/show?id=bd4266213f6' target=_blank style='color:#2F92EE;'>#清创#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66213, encryptionId=bd4266213f6, topicName=清创)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5a30305181, createdName=lingaifan, createdTime=Sun May 09 06:02:43 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957035, encodeId=64d5195e03516, content=<a href='/topic/show?id=92f46621471' target=_blank style='color:#2F92EE;'>#清创术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66214, encryptionId=92f46621471, topicName=清创术)], attachment=null, authenticateStatus=null, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1475034, encodeId=f0c614e50344a, content=<a href='/topic/show?id=935fe6718e3' target=_blank style='color:#2F92EE;'>#糖尿病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=68, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76718, encryptionId=935fe6718e3, topicName=糖尿病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a38f7243741, createdName=xue8604, createdTime=Mon Feb 01 13:02:43 CST 2021, time=2021-02-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921662, encodeId=a3c392166294, content=学海无涯苦作舟!, beContent=null, objectType=article, channel=null, level=null, likeNumber=126, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=287c2410703, createdName=Jason20042008, createdTime=Sun Jan 31 12:59:28 CST 2021, time=2021-01-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=921556, encodeId=9f1492155611, content=融合学科, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210127/50a003c4097845e182c08afd64d8a509/bd766dfebe9c40e0bca2dae964601bdc.jpg, createdBy=22de5454917, createdName=carrotlyl, createdTime=Sun Jan 31 07:14:25 CST 2021, time=2021-01-31, status=1, ipAttribution=)]
    2021-02-01 zblhy
  6. [GetPortalCommentsPageByObjectIdResponse(id=1700973, encodeId=8bdc1e00973ef, content=<a href='/topic/show?id=bd4266213f6' target=_blank style='color:#2F92EE;'>#清创#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66213, encryptionId=bd4266213f6, topicName=清创)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5a30305181, createdName=lingaifan, createdTime=Sun May 09 06:02:43 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957035, encodeId=64d5195e03516, content=<a href='/topic/show?id=92f46621471' target=_blank style='color:#2F92EE;'>#清创术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66214, encryptionId=92f46621471, topicName=清创术)], attachment=null, authenticateStatus=null, 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  7. 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  8. 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  9. [GetPortalCommentsPageByObjectIdResponse(id=1700973, encodeId=8bdc1e00973ef, content=<a href='/topic/show?id=bd4266213f6' target=_blank style='color:#2F92EE;'>#清创#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66213, encryptionId=bd4266213f6, topicName=清创)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ae5a30305181, createdName=lingaifan, createdTime=Sun May 09 06:02:43 CST 2021, time=2021-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1957035, encodeId=64d5195e03516, content=<a href='/topic/show?id=92f46621471' target=_blank style='color:#2F92EE;'>#清创术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66214, encryptionId=92f46621471, topicName=清创术)], attachment=null, authenticateStatus=null, 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    2021-01-31 Jason20042008

    学海无涯苦作舟!

    0

  10. 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    2021-01-31 carrotlyl

    融合学科

    0

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