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病例分享:在感染诊疗中,PCT的动态监测才是神助攻!

2017-12-09 佚名 梅里埃诊断

意大利曼图亚Carlo Poma医院ICU科室的GianPaolo CASTELLI医生,分享了一个PCT动态监测的病例,展示了PCT是如何通过诊断、预后、治疗和抗生素管理等在临床决策制定程序中提供附加值的。

临床医师每天都要面对许多挑战,特别是在感染诊治中的困难不断。

患者是否感染?感染的是什么病原体?如何使用抗生素?等等一系列问题都迫在眉梢,而降钙素原(PCT)的使用则为早期感染诊断和治疗反应评估提供了有效的方法。

意大利曼图亚Carlo Poma医院ICU科室的GianPaolo CASTELLI医生,分享了一个PCT动态监测的病例,展示了PCT是如何通过诊断、预后、治疗和抗生素管理等在临床决策制定程序中提供附加值的。

PCT动态监测病例分析

一名42岁男性病患,因严重外伤并带有粉碎性骨折和挤压综合征,在重症监护部住院。

入院理由

简化急性生理参数评分(SAPS)II:57;治疗介入评分系统(TISS):50;WBC:21000/µL;格拉斯哥昏迷指数(GCS):9(第5天,GCS:15)

处理

气管内插管和机械通气。中心静脉导管,动脉导管和导尿管,胸管和鼻胃管。48小时后,体外透析和到第5日的无尿症演变。每日微生物培养。在时间为0时(ICU治疗8天后)-从凝固酶阴性葡萄球菌发展出来的血流感染。患者在ICU部治疗了35天后转出。

参数的日常变化

CRP, PCT, Lactate(乳酸),BT(最高体温), WBC如图:



经验分享

对于送入ICU 8天后的外伤患者的脓毒症,PCT是诊断和监控的最佳生物标志物。根据PCT的峰值和随后的下降,可以清楚表明治疗过程的效果。建议对病危患者使用PCT动态检测,并作详细和持续的临床评估。

当然,PCT检测也不是完美的生物标志物,必须结合临床情况进行判读,尽量避免假阳性和假阴性的可能性。

PCT在我国的应用现状

在我国降钙素原(PCT)临床应用的专家共识中,明确建议对下列患者监测PCT趋势以评估抗生素治疗以及并发细菌感染的情况:

(1)监测和评估抗生素治疗效果

①所有接受抗生素治疗的患者;②需要暂停或者终止抗生素治疗的患者(建议每天检测);③需要治疗或监测感染灶的患者。

(2)监测并发细菌感染的情况

脓毒症或严重感染风险较高的患者(例如,制动、免疫功能缺陷、外伤、手术等)(建议每天检测)等。

同时,专家共识中关于PCT监测频率的推荐如下:

部分病例因脓毒症起病太快而未达到可检测PCT的时间窗(一般为起病3~6 h),因此对于有急性症状而PCT水平不高的患者,建议6~12 h后复查PCT。其他建议请参见表1。

表1对于PCT结果判读的建议

由此可见,需要动态监测PCT的情况有很多。作为一个强有力的辅助工具,临床医师应提高对PCT动态监测的重视程度,才能够有效助力临床到感染性疾病的诊断、分层、治疗和预后评估,合理使用抗生素等等问题。从而减少繁复的程序和时间,争取更高效的诊疗方法。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1924724, encodeId=21481924e242d, content=<a href='/topic/show?id=4fd31388ecf' target=_blank style='color:#2F92EE;'>#PCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13887, encryptionId=4fd31388ecf, topicName=PCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Aug 01 07:43:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276472, encodeId=3a3a2e647260, content=学习下.有了解过之前, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sun Jan 07 23:26:29 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268797, encodeId=a8c5268e977b, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Dec 12 07:23:52 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268419, encodeId=7de7268419b5, content=学习了.关注中, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/06/15/d6715bafce42cef990ac18b905ffc96c.JPG, createdBy=e1a3104890, createdName=Doctorbin, createdTime=Sun Dec 10 21:03:55 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268280, encodeId=bbe9268280da, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Dec 10 07:43:04 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268161, encodeId=06bb26816175, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 09 20:07:24 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268150, encodeId=1bee268150b5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Dec 09 18:51:54 CST 2017, time=2017-12-09, status=1, ipAttribution=)]
    2018-08-01 lvliquan
  2. [GetPortalCommentsPageByObjectIdResponse(id=1924724, encodeId=21481924e242d, content=<a href='/topic/show?id=4fd31388ecf' target=_blank style='color:#2F92EE;'>#PCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13887, encryptionId=4fd31388ecf, topicName=PCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Aug 01 07:43:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276472, encodeId=3a3a2e647260, content=学习下.有了解过之前, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sun Jan 07 23:26:29 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268797, encodeId=a8c5268e977b, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Dec 12 07:23:52 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268419, encodeId=7de7268419b5, content=学习了.关注中, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/06/15/d6715bafce42cef990ac18b905ffc96c.JPG, createdBy=e1a3104890, createdName=Doctorbin, createdTime=Sun Dec 10 21:03:55 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268280, encodeId=bbe9268280da, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Dec 10 07:43:04 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268161, encodeId=06bb26816175, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 09 20:07:24 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268150, encodeId=1bee268150b5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Dec 09 18:51:54 CST 2017, time=2017-12-09, status=1, ipAttribution=)]
    2018-01-07 明崖

    学习下.有了解过之前

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1924724, encodeId=21481924e242d, content=<a href='/topic/show?id=4fd31388ecf' target=_blank style='color:#2F92EE;'>#PCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13887, encryptionId=4fd31388ecf, topicName=PCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Aug 01 07:43:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276472, encodeId=3a3a2e647260, content=学习下.有了解过之前, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sun Jan 07 23:26:29 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268797, encodeId=a8c5268e977b, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Dec 12 07:23:52 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268419, encodeId=7de7268419b5, content=学习了.关注中, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/06/15/d6715bafce42cef990ac18b905ffc96c.JPG, createdBy=e1a3104890, createdName=Doctorbin, createdTime=Sun Dec 10 21:03:55 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268280, encodeId=bbe9268280da, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Dec 10 07:43:04 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268161, encodeId=06bb26816175, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 09 20:07:24 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268150, encodeId=1bee268150b5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Dec 09 18:51:54 CST 2017, time=2017-12-09, status=1, ipAttribution=)]
    2017-12-12 stupidox

    学习了,很好

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1924724, encodeId=21481924e242d, content=<a href='/topic/show?id=4fd31388ecf' target=_blank style='color:#2F92EE;'>#PCT#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13887, encryptionId=4fd31388ecf, topicName=PCT)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=796422, createdName=lvliquan, createdTime=Wed Aug 01 07:43:00 CST 2018, time=2018-08-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=276472, encodeId=3a3a2e647260, content=学习下.有了解过之前, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73441710184, createdName=明崖, createdTime=Sun Jan 07 23:26:29 CST 2018, time=2018-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268797, encodeId=a8c5268e977b, content=学习了,很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=48ce1618316, createdName=stupidox, createdTime=Tue Dec 12 07:23:52 CST 2017, time=2017-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268419, encodeId=7de7268419b5, content=学习了.关注中, beContent=null, objectType=article, channel=null, level=null, likeNumber=108, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/06/15/d6715bafce42cef990ac18b905ffc96c.JPG, createdBy=e1a3104890, createdName=Doctorbin, createdTime=Sun Dec 10 21:03:55 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268280, encodeId=bbe9268280da, content=学习学习.了解了解, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Dec 10 07:43:04 CST 2017, time=2017-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268161, encodeId=06bb26816175, content=学习了受益匪浅, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLDicHg2ldsSNmib46PmdzpO7CQEmPjuULp1v45zPWwMYhrnXgvl3OtmUCZSQfgITWn96X9moL94nUGA/0, createdBy=28072041016, createdName=131****1460, createdTime=Sat Dec 09 20:07:24 CST 2017, time=2017-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=268150, encodeId=1bee268150b5, content=学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6KcicAVC1MwuOgo3iaicb1Imgk1yIfnvr6oXzibcAFB6puAyNJXbzWhNuLqaFYBVRWjh7rghkvFLPxMAfD5ib3nXwVD/0, createdBy=bed21972958, createdName=wxl882001, createdTime=Sat Dec 09 18:51:54 CST 2017, time=2017-12-09, status=1, ipAttribution=)]
    2017-12-10 Doctorbin

    学习了.关注中

    0

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    2017-12-10 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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    2017-12-09 131****1460

    学习了受益匪浅

    0

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    2017-12-09 wxl882001

    学习一下

    0

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