Baidu
map

Science子刊:孕妈妈注意了,妊娠期运动可减少子代肥胖!

2020-04-21 王昭月 生物探索

目前,全球的肥胖率不断上升,普遍认为这是由于缺乏运动和摄入过多热量所致。而最近的一项研究发现了又一个新的解释,即缺乏妊娠锻炼。华盛顿州立大学动物科学的研究团队指出,妊娠期运动可促进发育中的胎儿产生棕色

目前,全球的肥胖率不断上升,普遍认为这是由于缺乏运动和摄入过多热量所致。而最近的一项研究发现了又一个新的解释,即缺乏妊娠锻炼。华盛顿州立大学动物科学的研究团队指出,妊娠期运动可促进发育中的胎儿产生棕色脂肪组织(brown adipose tissue , BAT),促进其体温生成和代谢健康。该结果发表在知名期刊《Science Advances》上。

研究者将健康的怀孕小鼠分为久坐或锻炼两种。然后,给他们的后代提供高能量/高热量的饮食。通过测定并比较妊娠期运动与久坐的精瘦小鼠以及她们后代的不同指标,如肩胛间棕色脂肪iBAT(interscapular BAT, iBAT)相对质量、腹股沟白色脂肪(inguinal WAT, ingWAT)相对质量以及血糖含量、糖耐量等。


孕期运动干预可明显诱导断奶时仔鼠iBAT和ingWAT表达热原标记物


结果发现,孕期运动不仅提高了母亲的iBAT活性,利于体重控制,同时还降低怀孕小鼠的循环血糖水平和胰岛素耐受性,表明对妊娠期糖尿病的预防作用。另一方面,断奶后仔鼠不同性别间差异的检测结果显示,与久坐组相比,运动组雌雄仔鼠的iBAT均增加,且雌鼠的ingWAT也相对减少。此外,棕色脂肪细胞标记物Ucp1, Ppargc1a和Prdm16的mRNA表达也有所增加,这表明妊娠期运动可促进胎儿和断奶后代小鼠的棕色和米色脂肪生成。

研究者还发现孕期运动还能刺激母亲和胎儿产生一种运动激素—apelin,它可以刺激棕色脂肪的发育,促进后代的代谢健康和体温生成。给久坐组的怀孕小鼠注射apelin,其作用与运动对后代产生的一样有益,这进一步表明当下妇女在怀孕期间久坐不动的生活方式可能是现代社会肥胖流行的原因之一。

孕期运动通可促进棕色脂肪形成并预防子代小鼠代谢功能障碍
来源于: 华盛顿州立大学 / Jun Seok Son

资深作者Min Du说,以前的研究表明,超重妇女在怀孕期间的运动可防止后代出现代谢障碍和肥胖,本研究表明这些益处也可能延伸到健康和身材匀称的女性后代身上。同时指出, apelinegic系统可能是开发预防肥胖的药物靶点。

原始出处:
Jun Seok Son1, et al. Maternal exercise via exerkine apelin enhances brown adipogenesis and prevents metabolic dysfunction in offspring mice. Science. 17 Apr 2020

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1932343, encodeId=f0e1193234339, content=<a href='/topic/show?id=97cc452e63f' target=_blank style='color:#2F92EE;'>#孕妈妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45276, encryptionId=97cc452e63f, topicName=孕妈妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Oct 12 18:06:36 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736270, encodeId=0ae61e36270c6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 08 23:06:36 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251250, encodeId=accc1251250a8, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376078, encodeId=009b13e607843, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=)]
    2020-10-12 lg.zhao
  2. [GetPortalCommentsPageByObjectIdResponse(id=1932343, encodeId=f0e1193234339, content=<a href='/topic/show?id=97cc452e63f' target=_blank style='color:#2F92EE;'>#孕妈妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45276, encryptionId=97cc452e63f, topicName=孕妈妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Oct 12 18:06:36 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736270, encodeId=0ae61e36270c6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 08 23:06:36 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251250, encodeId=accc1251250a8, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376078, encodeId=009b13e607843, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=)]
    2020-11-08 楚钟
  3. [GetPortalCommentsPageByObjectIdResponse(id=1932343, encodeId=f0e1193234339, content=<a href='/topic/show?id=97cc452e63f' target=_blank style='color:#2F92EE;'>#孕妈妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45276, encryptionId=97cc452e63f, topicName=孕妈妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Oct 12 18:06:36 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736270, encodeId=0ae61e36270c6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 08 23:06:36 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251250, encodeId=accc1251250a8, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376078, encodeId=009b13e607843, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1932343, encodeId=f0e1193234339, content=<a href='/topic/show?id=97cc452e63f' target=_blank style='color:#2F92EE;'>#孕妈妈#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=52, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45276, encryptionId=97cc452e63f, topicName=孕妈妈)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c737344, createdName=lg.zhao, createdTime=Mon Oct 12 18:06:36 CST 2020, time=2020-10-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1736270, encodeId=0ae61e36270c6, content=<a href='/topic/show?id=fd874512592' target=_blank style='color:#2F92EE;'>#子代#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=45125, encryptionId=fd874512592, topicName=子代)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e32134104358, createdName=楚钟, createdTime=Sun Nov 08 23:06:36 CST 2020, time=2020-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1251250, encodeId=accc1251250a8, content=<a href='/topic/show?id=90494486837' target=_blank style='color:#2F92EE;'>#妊娠期#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44868, encryptionId=90494486837, topicName=妊娠期)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0b7c20, createdName=wjcjjian, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376078, encodeId=009b13e607843, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=17a3387, createdName=jichang, createdTime=Thu Apr 23 12:06:36 CST 2020, time=2020-04-23, status=1, ipAttribution=)]
    2020-04-23 jichang

相关资讯

32岁孕妇突然腹痛!小心误诊了!

妊娠合并浆膜下子宫肌瘤蒂扭转1例

2020 WHO指南:埃博拉病背景下妊娠女性以及哺乳期女性的管理

2020年2月,世界卫生组织(WHO)发布了埃博拉病背景下妊娠女性以及哺乳期女性的管理指南,如何最佳管理妊娠以及哺乳期疑似或确诊埃博拉病(EVD)患者缺乏科学证据,历史报告认为,在妊娠期获得EVD的人群中,死亡率的发病率均增加,不良妊娠结局的发生率接近100%。本文主要针对埃博拉病背景下妊娠女性以及哺乳期女性的管理提供指导建议。

JAMA:冠状病毒在妊娠期的传播虽罕见,但确有发生!

近日,中国科学家在《JAMA Pediatrics》发表研究指出,患COVID-19疾病的孕妇有可能将病毒传染给新生儿,这种情况很少见但确有发生。

Semin Arthritis Rheu:孕次、产次与患类风湿性关节炎风险之间的关联

这项系统评价不支持孕次和产次与患RA风险之间存在关联的说法。

J Dent Res:牙周炎患者抗心磷脂对胎儿流产和膜联蛋白V的影响

15~20%的牙周炎患者血清中可发现抗心磷脂抗体的浓度升高,与不良妊娠、血栓性疾病以及抗磷脂综合征等自身免疫性疾病中加速动脉粥样硬化相关。我们之前的研究表明,在小鼠妊娠模型中,由于抗心磷脂抗体,小鼠抗

Semin Arthritis Rheu:孕期类风湿性关节炎改善的机制

尽管付出了巨大的努力,但妊娠引起RA改善的原因仍有待确定。妊娠各种短暂变化中的哪些引发了下游的抗炎免疫机制目前尚不清楚。

Baidu
map
Baidu
map
Baidu
map