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Curr Eye Res:HSV-1感染原代人角膜上皮细胞的长非编码RNA转录特征及整合分析

2018-07-25 MedSci MedSci原创

广州医科大学基础医学院附属第二医院心血管病研究所的Cui YH等近日在Curr Eye Res发表了一篇重要的研究论文,他们研究了HSV-1感染的原发性角膜上皮细胞中lncRNAs和mRNAs表达的全基因组图谱。

广州医科大学基础医学院附属第二医院心血管病研究所的Cui YH等近日在Curr Eye Res发表了一篇重要的研究论文,他们研究了HSV-1感染的原发性角膜上皮细胞中lncRNAs和mRNAs表达的全基因组图谱。

目前已证明长的非编码RNA(lncRNA)在多种细胞过程中具有重要的调节功能。然而,lncRNAs在单纯疱疹性角膜炎发病机制中的作用仍然知之甚少。

他们用HSV-1感染原代人角膜上皮细胞,从感染组和模拟感染组中提取的总RNA进行微阵列分析,以鉴定lncRNA和mRNA的差异表达。他们还进行生物信息学分析,包括基因本体分析、信号途径分析和共表达网络分析。

与模拟感染组相比,数千个lncRNA和mRNA的表达发生显着改变,微阵列结果通过qRT-PCR进行了验证。上调的转录本富集的GO中,最显着的是防御反应、质膜的内在组分和细胞因子活性;下调的转录本富集的GO中最显着的是细胞代谢过程、细胞内部分和poly(A)RNA结合。信号途径分析表明,上调和下调转录物的最相关信号途径分别是细胞因子与细胞因子受体相互作用和RNA转运。

因此,他们的研究清晰的描述了HSV-1感染的原发性角膜上皮细胞中lncRNAs和mRNAs表达的全基因组图谱。这些转录组数据以及随后的生物信息学分析将为眼科研究者提供新的线索,以深入了解单纯疱疹性角膜炎的分子机制和潜在治疗靶点。进一步的研究有望验证潜在的功能基因和信号途径,并探索关键lncRNAs的作用。

原文出处:

Cui, Y.H., et al., Transcriptional Profile and Integrative Analyses of Long Non-Coding RNAs in Primary Human Corneal Epithelial Cells in Response to HSV-1 Infection. Curr Eye Res, 2018.

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    2022-12-27 ms6000001411380643 来自广东省

    希望国家重视!单纯疱疹要害死人,加快根治药物研究

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    2019-03-15 mjldent
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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042355, encodeId=cefc204235553, content=<a href='/topic/show?id=37a090929f5' target=_blank style='color:#2F92EE;'>#角膜上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90929, encryptionId=37a090929f5, topicName=角膜上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Thu Apr 04 10:13:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941646, encodeId=ec2a194164644, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Mar 27 07:13:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743473, encodeId=9de61e4347308, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Nov 08 22:13:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029862, encodeId=3da2202986253, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Apr 12 14:13:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813645, encodeId=07ae18136454d, content=<a href='/topic/show?id=c59d9336e5d' target=_blank style='color:#2F92EE;'>#转录特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93367, encryptionId=c59d9336e5d, topicName=转录特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32a12500167, createdName=12498ca5m83暂无昵称, createdTime=Thu Jun 20 19:13:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987768, encodeId=7dd2198e768ed, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Tue Aug 28 06:13:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349145, encodeId=1c831349145e4, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2019-03-27 gracezdd
  5. [GetPortalCommentsPageByObjectIdResponse(id=2107660, encodeId=1afe210e66033, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:46:12 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1747318, encodeId=bc4b1e473182f, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Fri Mar 15 01:13:00 CST 2019, time=2019-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042355, encodeId=cefc204235553, content=<a href='/topic/show?id=37a090929f5' target=_blank style='color:#2F92EE;'>#角膜上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90929, encryptionId=37a090929f5, topicName=角膜上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Thu Apr 04 10:13:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941646, encodeId=ec2a194164644, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Mar 27 07:13:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743473, encodeId=9de61e4347308, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Nov 08 22:13:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029862, encodeId=3da2202986253, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Apr 12 14:13:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813645, encodeId=07ae18136454d, content=<a href='/topic/show?id=c59d9336e5d' target=_blank style='color:#2F92EE;'>#转录特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93367, encryptionId=c59d9336e5d, topicName=转录特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32a12500167, createdName=12498ca5m83暂无昵称, createdTime=Thu Jun 20 19:13:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987768, encodeId=7dd2198e768ed, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Tue Aug 28 06:13:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349145, encodeId=1c831349145e4, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2018-11-08 d830384
  6. [GetPortalCommentsPageByObjectIdResponse(id=2107660, encodeId=1afe210e66033, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:46:12 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1747318, encodeId=bc4b1e473182f, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Fri Mar 15 01:13:00 CST 2019, time=2019-03-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2042355, encodeId=cefc204235553, content=<a href='/topic/show?id=37a090929f5' target=_blank style='color:#2F92EE;'>#角膜上皮#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=84, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90929, encryptionId=37a090929f5, topicName=角膜上皮)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8e0333, createdName=zhangyxzsh, createdTime=Thu Apr 04 10:13:00 CST 2019, time=2019-04-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1941646, encodeId=ec2a194164644, content=<a href='/topic/show?id=48c291689e' target=_blank style='color:#2F92EE;'>#HSV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9168, encryptionId=48c291689e, topicName=HSV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=872f168, createdName=gracezdd, createdTime=Wed Mar 27 07:13:00 CST 2019, time=2019-03-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1743473, encodeId=9de61e4347308, content=<a href='/topic/show?id=369199618db' target=_blank style='color:#2F92EE;'>#非编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99618, encryptionId=369199618db, topicName=非编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=32d435134939, createdName=d830384, createdTime=Thu Nov 08 22:13:00 CST 2018, time=2018-11-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029862, encodeId=3da2202986253, content=<a href='/topic/show?id=fedde18245' target=_blank style='color:#2F92EE;'>#eye#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7182, encryptionId=fedde18245, topicName=eye)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/1103841572/7F67E3BE360D6DD1D0A62E3E71E23CB6/100, createdBy=9d8a2500148, createdName=ms8888626721583891, createdTime=Fri Apr 12 14:13:00 CST 2019, time=2019-04-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1813645, encodeId=07ae18136454d, content=<a href='/topic/show?id=c59d9336e5d' target=_blank style='color:#2F92EE;'>#转录特征#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93367, encryptionId=c59d9336e5d, topicName=转录特征)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32a12500167, createdName=12498ca5m83暂无昵称, createdTime=Thu Jun 20 19:13:00 CST 2019, time=2019-06-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987768, encodeId=7dd2198e768ed, content=<a href='/topic/show?id=34899169fe' target=_blank style='color:#2F92EE;'>#HSV-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=94, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9169, encryptionId=34899169fe, topicName=HSV-1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6eba113, createdName=xiaoyeshuang, createdTime=Tue Aug 28 06:13:00 CST 2018, time=2018-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1349145, encodeId=1c831349145e4, content=<a href='/topic/show?id=4337909284a' target=_blank style='color:#2F92EE;'>#角膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90928, encryptionId=4337909284a, topicName=角膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=568152, createdName=snowpeakxu, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=2107660, encodeId=1afe210e66033, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:46:12 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1747318, encodeId=bc4b1e473182f, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Fri Mar 15 01:13:00 CST 2019, time=2019-03-15, status=1, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  8. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
  9. [GetPortalCommentsPageByObjectIdResponse(id=2107660, encodeId=1afe210e66033, content=希望国家重视!单纯疱疹要害死人,加快根治药物研究, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68a38490885, createdName=ms6000001411380643, createdTime=Tue Dec 27 12:46:12 CST 2022, time=2022-12-27, status=1, ipAttribution=广东省), GetPortalCommentsPageByObjectIdResponse(id=1747318, encodeId=bc4b1e473182f, content=<a href='/topic/show?id=832e93345c3' target=_blank style='color:#2F92EE;'>#转录#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=93345, encryptionId=832e93345c3, topicName=转录)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=58df35929710, createdName=mjldent, createdTime=Fri Mar 15 01:13:00 CST 2019, time=2019-03-15, status=1, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1366099, encodeId=439e136609947, content=<a href='/topic/show?id=771f9e09207' target=_blank style='color:#2F92EE;'>#长非编码RNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97092, encryptionId=771f9e09207, topicName=长非编码RNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=920c231, createdName=lixiaol, createdTime=Fri Jul 27 13:13:00 CST 2018, time=2018-07-27, status=1, ipAttribution=)]
    2018-07-27 snowpeakxu
  10. 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