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Nat Metab:细胞的“酸碱体质”可以调节肿瘤生长

2020-11-04 haibei MedSci原创

癌细胞的生长和增殖增强伴随着细胞代谢的深刻变化。这些代谢变化在生理条件下也是常见的,包括葡萄糖酵解增加,伴随着细胞pH值(pHc)的升高。然而,至今为止,这些变化如何帮助增强细胞的生长和增殖还不清楚。

癌细胞的生长和增殖增强伴随着细胞代谢的深刻变化。这些代谢变化在生理条件下也是常见的,包括葡萄糖酵解增加,伴随着细胞pH值(pHc)的升高。然而,至今为止,这些变化如何帮助增强细胞的生长和增殖还不清楚。

最近,研究人员在Nature Metabolism杂志发文表明,pHc升高专门协调一个E2F依赖性的转录程序,通过促进cyclin D1的表达,推动细胞增殖。

pHc依赖性cyclin D1的转录需要转录因子CREB1,ATF1和ETS1,和组蛋白乙酰转移酶p300和CBP的帮助。生化表征显示,CREB1-p300/CBP相互作用作为pH传感器和巧合检测器,整合不同的有丝分裂信号来调控cyclin D1的转录。

研究人员还表明,pHc的升高有助于恶性胸膜间皮瘤(MPMs)中cyclin D1表达的增加,并使这些细胞对pHc的药理降低不敏感。

综上所述,这些数据表明pHc升高是调节G1进展的关键细胞信号,并提供了一种机制,将pHc升高与MPMs,以及其他可能的cyclin D1依赖性肿瘤中cyclin D1的致癌激活联系起来。

因此,pHc的增加可能代表了癌症病因学中一个功能上重要的早期事件,可以进行治疗干预。

 

原始出处:

Lisa Maria Koch et al. Cytosolic pH regulates proliferation and tumour growth by promoting expression of cyclin D1. Nature Metabolism (2020). 

 

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    2021-07-18 liye789132251
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    2021-04-21 一闲
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    2021-01-06 ms3000001890169759

    很好

    0

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    2021-04-11 guojianrong
  5. [GetPortalCommentsPageByObjectIdResponse(id=1884772, encodeId=df351884e72d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Jul 18 10:33:01 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896770, encodeId=e0761896e7088, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 21 02:33:01 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914049, encodeId=e14491404997, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210106/6edc3e6f9d304c34acf3c6d37674d6f1/2ff401f23c9f4a9bb068767e90ff7b17.jpg, createdBy=384a5430914, createdName=ms3000001890169759, createdTime=Wed Jan 06 11:30:27 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888234, encodeId=19891888234be, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Apr 11 04:33:01 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896946, encodeId=cf37896946d1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e851851042, createdName=ms4211127491864495, createdTime=Wed Nov 04 21:18:13 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896907, encodeId=61c489690e1b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42633007966, createdName=983929547, createdTime=Wed Nov 04 17:40:56 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896904, encodeId=a94b896904ff, content=<a href='/topic/show?id=dfd0956047a' target=_blank style='color:#2F92EE;'>#酸碱体质#</a>这是形象说法,其实是肿瘤通过代谢产生大量的<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>,乳酸能促进肿瘤增长与转移。, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95604, encryptionId=dfd0956047a, topicName=酸碱体质), TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Nov 04 17:38:10 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896877, encodeId=307a8968e788, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/b6c33943ed6c4b1ba2141ec4bdad35bf/ec0c8359538f4f4994d151b4bbc6a05a.jpg, createdBy=61ee5340187, createdName=ms7000001325239398, createdTime=Wed Nov 04 15:47:17 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-04 ms4211127491864495

    学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1884772, encodeId=df351884e72d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Jul 18 10:33:01 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896770, encodeId=e0761896e7088, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 21 02:33:01 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914049, encodeId=e14491404997, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210106/6edc3e6f9d304c34acf3c6d37674d6f1/2ff401f23c9f4a9bb068767e90ff7b17.jpg, createdBy=384a5430914, createdName=ms3000001890169759, createdTime=Wed Jan 06 11:30:27 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888234, encodeId=19891888234be, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Apr 11 04:33:01 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896946, encodeId=cf37896946d1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e851851042, createdName=ms4211127491864495, createdTime=Wed Nov 04 21:18:13 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896907, encodeId=61c489690e1b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42633007966, createdName=983929547, createdTime=Wed Nov 04 17:40:56 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896904, encodeId=a94b896904ff, content=<a href='/topic/show?id=dfd0956047a' target=_blank style='color:#2F92EE;'>#酸碱体质#</a>这是形象说法,其实是肿瘤通过代谢产生大量的<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>,乳酸能促进肿瘤增长与转移。, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95604, encryptionId=dfd0956047a, topicName=酸碱体质), TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Nov 04 17:38:10 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896877, encodeId=307a8968e788, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/b6c33943ed6c4b1ba2141ec4bdad35bf/ec0c8359538f4f4994d151b4bbc6a05a.jpg, createdBy=61ee5340187, createdName=ms7000001325239398, createdTime=Wed Nov 04 15:47:17 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-04 983929547

    很好

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1884772, encodeId=df351884e72d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Jul 18 10:33:01 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896770, encodeId=e0761896e7088, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 21 02:33:01 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914049, encodeId=e14491404997, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210106/6edc3e6f9d304c34acf3c6d37674d6f1/2ff401f23c9f4a9bb068767e90ff7b17.jpg, createdBy=384a5430914, createdName=ms3000001890169759, createdTime=Wed Jan 06 11:30:27 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888234, encodeId=19891888234be, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Apr 11 04:33:01 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896946, encodeId=cf37896946d1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e851851042, createdName=ms4211127491864495, createdTime=Wed Nov 04 21:18:13 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896907, encodeId=61c489690e1b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42633007966, createdName=983929547, createdTime=Wed Nov 04 17:40:56 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896904, encodeId=a94b896904ff, content=<a href='/topic/show?id=dfd0956047a' target=_blank style='color:#2F92EE;'>#酸碱体质#</a>这是形象说法,其实是肿瘤通过代谢产生大量的<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>,乳酸能促进肿瘤增长与转移。, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95604, encryptionId=dfd0956047a, topicName=酸碱体质), TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Nov 04 17:38:10 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896877, encodeId=307a8968e788, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/b6c33943ed6c4b1ba2141ec4bdad35bf/ec0c8359538f4f4994d151b4bbc6a05a.jpg, createdBy=61ee5340187, createdName=ms7000001325239398, createdTime=Wed Nov 04 15:47:17 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-04 lovetcm

    #酸碱体质#这是形象说法,其实是肿瘤通过代谢产生大量的#乳酸#,乳酸能促进肿瘤增长与转移。

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1884772, encodeId=df351884e72d4, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=95, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Sun Jul 18 10:33:01 CST 2021, time=2021-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896770, encodeId=e0761896e7088, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Wed Apr 21 02:33:01 CST 2021, time=2021-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=914049, encodeId=e14491404997, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=145, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210106/6edc3e6f9d304c34acf3c6d37674d6f1/2ff401f23c9f4a9bb068767e90ff7b17.jpg, createdBy=384a5430914, createdName=ms3000001890169759, createdTime=Wed Jan 06 11:30:27 CST 2021, time=2021-01-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1888234, encodeId=19891888234be, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sun Apr 11 04:33:01 CST 2021, time=2021-04-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896946, encodeId=cf37896946d1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=153, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1e851851042, createdName=ms4211127491864495, createdTime=Wed Nov 04 21:18:13 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896907, encodeId=61c489690e1b, content=很好, beContent=null, objectType=article, channel=null, level=null, likeNumber=128, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=42633007966, createdName=983929547, createdTime=Wed Nov 04 17:40:56 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896904, encodeId=a94b896904ff, content=<a href='/topic/show?id=dfd0956047a' target=_blank style='color:#2F92EE;'>#酸碱体质#</a>这是形象说法,其实是肿瘤通过代谢产生大量的<a href='/topic/show?id=9d1523811e6' target=_blank style='color:#2F92EE;'>#乳酸#</a>,乳酸能促进肿瘤增长与转移。, beContent=null, objectType=article, channel=null, level=null, likeNumber=173, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95604, encryptionId=dfd0956047a, topicName=酸碱体质), TopicDto(id=23811, encryptionId=9d1523811e6, topicName=乳酸)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220519/c2ab253484ee4527a2d4e9589a4821ac/45de9bf494a54becb2ea4369c9d11e85.jpg, createdBy=7a3710, createdName=lovetcm, createdTime=Wed Nov 04 17:38:10 CST 2020, time=2020-11-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=896877, encodeId=307a8968e788, content=不错, beContent=null, objectType=article, channel=null, level=null, likeNumber=120, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20201104/b6c33943ed6c4b1ba2141ec4bdad35bf/ec0c8359538f4f4994d151b4bbc6a05a.jpg, createdBy=61ee5340187, createdName=ms7000001325239398, createdTime=Wed Nov 04 15:47:17 CST 2020, time=2020-11-04, status=1, ipAttribution=)]
    2020-11-04 ms7000001325239398

    不错

    0

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