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JCO:儿童癌症幸存者的不良结局存在种族差异吗?

2016-03-29 MedSci MedSci原创

 在过去的四十年中,对于儿童癌症的治疗已经取得的长足的进展,数据显示儿童癌症患者的五年生存率已经达到了85%。伴随着儿童癌症幸存者数量的增加,有必要考虑癌症及其相应的治疗对于儿童的长期影响。早前的研究表明儿童癌症幸存者承受着巨大的发病率和过早死亡的压力。但是鲜有研究关注这一压力在不同种族的儿童癌症幸存者中的差异。 来自加拿大的华人科学家Qi Liu以第一作者身份发表在《临床肿瘤

在过去的四十年中,对于儿童癌症的治疗已经取得的长足的进展,数据显示儿童癌症患者的五年生存率已经达到了85%。伴随着儿童癌症幸存者数量的增加,有必要考虑癌症及其相应的治疗对于儿童的长期影响。早前的研究表明儿童癌症幸存者承受着巨大的发病率和过早死亡的压力。但是鲜有研究关注这一压力在不同种族的儿童癌症幸存者中的差异。

来自加拿大的华人科学家Qi Liu以第一作者身份发表在《临床肿瘤学杂志》上的一篇论文揭示了儿童癌症幸存者不良结局的种族差异。数据来自于儿童癌症幸存者研究。幸存者均是在癌症后生存超过五年。研究人员比较了西班牙裔(750人,5.4%)和非西班牙裔黑人(NHB,694人,5.0%)以及非西班牙裔白人(NHW,12397人,89.6%)患者的后期死亡率、随后的肿瘤发病情况以及慢性疾病。NHB和西班牙裔社会经济地位更低且肥胖的流行率更高,NHB有更高的高血压流行性。NHB有更高的全因死亡率的比例。在接受放疗的NHB中,未发现非黑色素瘤皮肤癌,西班牙裔的幸存者的风险也更低于NHW。NHB和西班牙裔患糖尿病的风险更高。治疗暴露并没有影响死亡率(全因或者具体的原因)、慢性疾病或者随后发生的肿瘤的种族差异性。

通过大规模的数据研究发现,NHB和西班牙裔儿童癌症幸存者有着更大死亡率和发病率的负担。少数的风险差异可以通过社会经济状况的差异或者心血管风险因素的种族差异进行解释。

原始出处:
Qi Liu et al. Racial/Ethnic Differences in Adverse Outcomes Among Childhood Cancer Survivors: The Childhood Cancer Survivor Study. JCO. Published Ahead of Print on March 21, 2016 as 10.1200/JCO.2015.66.3567

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    2017-03-14 lidong40
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    2016-03-30 Gsurgeon

    不错学习了

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