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J Allergy Clin Immunol Pract:产前维生素D与儿童早期气源性过敏原致敏和过敏性鼻炎的关系

2021-06-30 AlexYang MedSci原创

维生素D具有免疫调节作用,可能对过敏性疾病的发展具有重要作用,也许早在胎儿发育的前三个月就开始起作用了。研究表明,母体的维生素D可以自由穿过胎盘,其水平可以通过母体的饮食和补充来改变。维生素D的缺乏已

维生素D具有免疫调节作用,可能对过敏性疾病的发展具有重要作用,也许早在胎儿发育的前三个月就开始起作用了。研究表明,母体的维生素D可以自由穿过胎盘,其水平可以通过母体的饮食和补充来改变。维生素D的缺乏已质疑为过敏性鼻炎和环境气源性过敏原致敏的一个因素。然而,尽管一些研究表明产前维生素D充足对后代的过敏性鼻炎和哮喘有预防作用,产前补充维生素D对预防过敏性鼻炎的作用仍不清楚。

近期,有研究人员在VDAART试验中,调查了产前维生素D与儿童过敏性结果的关系,VDAART试验是一项产前维生素D补充的随机对照试验

分析包括414对母子,包括了后代6岁时气源性过敏原敏感数据。他们调查了产前维生素D充足状况(基于第一个三个月和第三个三个月测量的维生素D水平)或维生素D补充治疗情况与3岁和6岁时气源性过敏原致敏、父母报告的临床过敏性鼻炎、父母报告的临床过敏性鼻炎与气源性过敏原致敏、食物致敏、任何致敏、湿疹和总IgE之间的关系。

结果发现,与早期和晚期维生素D不足相比,早期产前维生素D不足而晚期充足与3岁(aOR=0.34,95%CI 0.13,0.82,p=0.02)和6岁(aOR 0.54,95%CI 0.29,0.98,p=0.05)的临床过敏性鼻炎和气源性过敏原致敏的发展减少有关。6岁时,与母亲接受低剂量维生素D的后代相比,母亲接受高剂量维生素D的后代临床过敏性鼻炎的致敏率明显下降(aOR 0.54,95%CI 0.32,0.91,p=0.02)。

6岁时产前维生素D与过敏性结果的关系

综上所述,在前三个月维生素D不足的母亲中,第三个三个月的产前维生素D充足对3岁和6岁时临床过敏性鼻炎和气源性过敏原致敏的发展有预防作用

原始出处:

Yih-Chieh S Chen, Hooman Mirzakhani, Mengdi Lu et al. The association of prenatal vitamin D sufficiency with aeroallergen sensitization and allergic rhinitis in early childhood. J Allergy Clin Immunol Pract. Jun 2021

 

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    2022-02-16 ms8000002131411968

    还是要早补充

    0

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    2021-07-09 智慧药

    学习了,感谢平台

    0

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    2021-07-02 膀胱癌
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    2021-07-02 qilu_qi
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    2021-06-30 ms1000000453420389

    维生素片剂可以试一下

    0

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