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J Transl Med:口腔扁平苔藓患者HCMV编码miRNA表达模式明显不同

2017-08-07 MedSci MedSci原创

口腔扁平苔藓(OLP)是T细胞介导的免疫性疾病。口腔扁平苔藓的病因及分子机制目前仍不清楚。人巨细胞病毒(HCMV)感染是多种疾病发展的一个因素,但是HCMV在 OLP的临床相关性上目前还并不了解。研究共纳入了21名OLP患者和18名健康对照者,收集器血浆样本,使用RT-qPCR 检查了23个HCMV编码的microRNA(miRNA)。随后在包括40例OLP患者和33名健康对照者的更大队列中验证了

口腔扁平苔藓(OLP)是T细胞介导的免疫性疾病。口腔扁平苔藓的病因及分子机制目前仍不清楚。人巨细胞病毒(HCMV)感染是多种疾病发展的一个因素,但是HCMV在 OLP的临床相关性上目前还并不了解。 研究共纳入了21名OLP患者和18名健康对照者,收集器血浆样本,使用RT-qPCR 检查了23个HCMV编码的microRNA(miRNA)。随后在包括40例OLP患者和33名健康对照者的更大队列中验证了表达差异的miRNAs。同时在包含13名OLP患者和12名对照者的队列中测量其外周血白细胞(PBL)中的HCMV DNA。此外,研究人员还使用生物信息学分析、荧光素酶报告分析和免疫印迹等方法预测并验证HCMV编码miRNAs的直接靶点。 RT-qPCR结果显示,几组队列中OLP患者血浆中五种HCMV编码miRNAs的水平均显著高于对照者,包括hcmv-mir-ul112-3p,hcmv-mir-ul22a-5p,hcmv-mir-ul148d,hcmv-mir-ul36-5p和hcmv-mir-ul59。PBLs中HCMV DNA同样也是OLP患者明显高于对照组。此外,通过结合使用荧光素

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    2018-03-14 zhaohui6731
  3. 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    2017-12-26 bsmagic9140
  4. 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href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Nov 03 08:05:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312300, encodeId=d0cf1312300e4, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2018-04-09 wolongzxh
  5. [GetPortalCommentsPageByObjectIdResponse(id=1793428, encodeId=b7461e9342831, content=<a href='/topic/show?id=d96c155e526' target=_blank style='color:#2F92EE;'>#RNA表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15575, encryptionId=d96c155e526, topicName=RNA表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Mon Dec 04 09:05:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966882, encodeId=6d2f196688294, content=<a href='/topic/show?id=91298559a0' target=_blank style='color:#2F92EE;'>#HCMV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8559, encryptionId=91298559a0, topicName=HCMV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, 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href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Nov 03 08:05:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312300, encodeId=d0cf1312300e4, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, 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createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
  6. 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href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Nov 03 08:05:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312300, encodeId=d0cf1312300e4, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-11-03 smallant2002
  7. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-09 Homburg
  8. [GetPortalCommentsPageByObjectIdResponse(id=1793428, encodeId=b7461e9342831, content=<a href='/topic/show?id=d96c155e526' target=_blank style='color:#2F92EE;'>#RNA表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15575, encryptionId=d96c155e526, topicName=RNA表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Mon Dec 04 09:05:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966882, encodeId=6d2f196688294, content=<a href='/topic/show?id=91298559a0' target=_blank style='color:#2F92EE;'>#HCMV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8559, encryptionId=91298559a0, topicName=HCMV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Wed Mar 14 11:05:00 CST 2018, time=2018-03-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1656844, encodeId=aca2165684496, content=<a href='/topic/show?id=3ca31e71903' target=_blank style='color:#2F92EE;'>#TRA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=101, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17719, encryptionId=3ca31e71903, topicName=TRA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=757b24868428, createdName=bsmagic9140, createdTime=Tue Dec 26 01:05:00 CST 2017, time=2017-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1652660, encodeId=f5911652660a6, content=<a href='/topic/show?id=0bb7491186' target=_blank style='color:#2F92EE;'>#CMV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4911, encryptionId=0bb7491186, topicName=CMV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f5424318202, createdName=wolongzxh, createdTime=Mon Apr 09 11:05:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067263, encodeId=d40f206e263de, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Sep 11 21:05:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930483, encodeId=586819304837f, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Nov 03 08:05:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312300, encodeId=d0cf1312300e4, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
    2017-08-09 仁者大医
  9. [GetPortalCommentsPageByObjectIdResponse(id=1793428, encodeId=b7461e9342831, content=<a href='/topic/show?id=d96c155e526' target=_blank style='color:#2F92EE;'>#RNA表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15575, encryptionId=d96c155e526, topicName=RNA表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Mon Dec 04 09:05:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966882, encodeId=6d2f196688294, content=<a href='/topic/show?id=91298559a0' target=_blank style='color:#2F92EE;'>#HCMV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8559, encryptionId=91298559a0, topicName=HCMV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, 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encryptionId=0bb7491186, topicName=CMV)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3f5424318202, createdName=wolongzxh, createdTime=Mon Apr 09 11:05:00 CST 2018, time=2018-04-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067263, encodeId=d40f206e263de, content=<a href='/topic/show?id=d0841e75535' target=_blank style='color:#2F92EE;'>#Transl#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17755, encryptionId=d0841e75535, topicName=Transl)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdqq.qlogo.cn/qqapp/101173734/363C99735735B7F4CB11D5F78F580525/100, createdBy=aab22500211, createdName=ms3025846204744509, createdTime=Mon Sep 11 21:05:00 CST 2017, time=2017-09-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1930483, encodeId=586819304837f, content=<a href='/topic/show?id=22f61180211' target=_blank style='color:#2F92EE;'>#miR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11802, encryptionId=22f61180211, topicName=miR)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0a27288, createdName=smallant2002, createdTime=Fri Nov 03 08:05:00 CST 2017, time=2017-11-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1312300, encodeId=d0cf1312300e4, content=<a href='/topic/show?id=e5571193321' target=_blank style='color:#2F92EE;'>#miRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11933, encryptionId=e5571193321, topicName=miRNA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e87d405, createdName=Homburg, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
  10. [GetPortalCommentsPageByObjectIdResponse(id=1793428, encodeId=b7461e9342831, content=<a href='/topic/show?id=d96c155e526' target=_blank style='color:#2F92EE;'>#RNA表达#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15575, encryptionId=d96c155e526, topicName=RNA表达)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=72bf2500198, createdName=小小小向日葵, createdTime=Mon Dec 04 09:05:00 CST 2017, time=2017-12-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1966882, encodeId=6d2f196688294, content=<a href='/topic/show?id=91298559a0' target=_blank style='color:#2F92EE;'>#HCMV#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8559, encryptionId=91298559a0, topicName=HCMV)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1478112, encodeId=a04314e811228, content=<a href='/topic/show?id=f51a8556cc' target=_blank style='color:#2F92EE;'>#HCM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8556, encryptionId=f51a8556cc, topicName=HCM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1582192, encodeId=ff6d1582192a2, content=<a href='/topic/show?id=71183830280' target=_blank style='color:#2F92EE;'>#口腔扁平苔藓#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=92, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=38302, encryptionId=71183830280, topicName=口腔扁平苔藓)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f26316894523, createdName=ms7019579240139182, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1584670, encodeId=84ce15846e0fb, content=<a href='/topic/show?id=83f5e9250e9' target=_blank style='color:#2F92EE;'>#编码#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79250, encryptionId=83f5e9250e9, topicName=编码)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b10a17056098, createdName=12498f6em12暂无昵称, createdTime=Wed Aug 09 05:05:00 CST 2017, time=2017-08-09, status=1, ipAttribution=)]
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