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Stroke:双侧皮质下病变影响缺血性卒中患者的吞咽功能恢复

2020-02-21 国际循环 网络

卒中发作后患者通常面临吞咽困难问题,吞咽功能恢复的时间长短存在差异。近期,Stroke杂志发表研究,旨在探讨影响卒中发作后吞咽困难患者吞咽功能长期恢复情况的临床和放射学预后因素,并利用机器学习算法建立并验证了一个预后模型。

卒中发作后患者通常面临吞咽困难问题,吞咽功能恢复的时间长短存在差异。近期,Stroke杂志发表研究,旨在探讨影响卒中发作后吞咽困难患者吞咽功能长期恢复情况的临床和放射学预后因素,并利用机器学习算法建立并验证了一个预后模型。
 
研究回顾性分析137例接受吞咽功能检查的急性缺血性卒中患者,对其卒中发作后6个月的吞咽困难进行监测,并用Kaplan-Meier法和Cox回归模型分析影响吞咽功能的临床和放射学因素。利用潜在预后因素建立贝叶斯网络模型,将患者分为吞咽功能恢复良好(6个月无需管饲或饮食调整)和吞咽功能恢复不良(6个月管饲或饮食调整)两类。
 

图1. 恢复情况图像演示
 
研究结果显示,24例(17.5%)患者在前6个月出现持续性吞咽困难,平均持续时间65.6天。卒中后吞咽困难的持续时间因管饲状态、吞咽困难程度、性别、白质高强度严重程度、双侧放射冠/基底节/内囊病变(CR/BG/IC)等因素差异显著。其中,Cox回归模型多因素分析显示,管饲状态(P<0.001)、双侧CR/BG/IC病变(P=0.001)和临床吞咽困难评分(P=0.042)是影响吞咽功能的重要预后因素。此外,树状网络增强分类器基于10个因素(性别、CR、BG/IC和脑岛病变、侧性、脑干前外侧区、CR/BG/IC双侧病变、严重白质高强度、临床吞咽困难分级和管饲状态)对患者进行分层,比本研究开发的其他基准分类器的更准确。

 

图2. 卒中后吞咽障碍患者吞咽恢复的Kaplan-Meier图
 

图3. 卒中后吞咽障碍患者吞咽恢复的Kaplan-Meier图
 
这项研究表明,吞咽困难的严重程度和CR/BG/IC的双侧病变是6个月吞咽功能恢复的重要预后因素。基于临床和放射学因素,可将贝叶斯网络模型用于预测患者6个月吞咽功能的恢复情况。此外,研究人员强调,双侧皮质下病变是非常重要的吞咽功能恢复预后因素,基于此可建立长期吞咽恢复的预测模型。
 
原始出处:
Woo Hyung Lee, Min Hyuk Lim, et al. Development of a Novel Prognostic Model to Predict 6-Month Swallowing Recovery After Ischemic Stroke. Stroke. Originally published30 Dec 2019

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    2020-02-23 mnda
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    2020-02-21 健健

    卒中虽然是临床上常见病,溶栓,取栓等血管内治疗也很成熟,但是仍然有很多未知问题有待认知!

    0

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