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Am J Respir Crit Care Med:COPD可增加卒中风险,抽烟是两者共同的危险因素

2015-10-26 phylis 译 MedSci原创

背景:慢性阻塞性肺疾病(COPD)和卒中是世界上最主要的死因。有证据证明这两种疾病存在相关性,COPD患者由动脉粥样硬化风险增加引起,或者卒中和COPD有共同的危险因子。目的:为了调查一般人群中COPD和卒中个亚型的相关性,并且探索心血管危险因素的作用,是否增加这种相关性。方法:前瞻性基于群体的鹿特丹研究中,研究者随访了13115名物卒中史的受试者。随访从1990-2008年开始,2012年结束。

背景:慢性阻塞性肺疾病(COPD)和卒中是世界上最主要的死因。有证据证明这两种疾病存在相关性,COPD患者由动脉粥样硬化风险增加引起,或者卒中和COPD有共同的危险因子。

目的:为了调查一般人群中COPD和卒中个亚型的相关性,并且探索心血管危险因素的作用,是否增加这种相关性。

方法:前瞻性基于群体的鹿特丹研究中,研究者随访了13115名无卒中史的受试者。随访从1990-2008年开始,2012年结束。应用时间依赖Cox风险比例弄醒分析COPD和卒中的相关性。

结果:1566名受试者存在COPD,1250受试者发生卒中,其中701名患者发生缺血性卒中,107发生出血性卒中。校正年龄、性别,COPD与所有卒中(HR 1.20; 95%CI 1.00-1.43)、缺血性卒中(HR 1.27; 1.02-1.59)和出血性卒中(HR 1.70; 1.01-2.84)都显著相关。校正心血管危险因素有相同的结果。相反,校正抽烟,缓解影响效应:所有卒中(HR 1.09; 0.91-1.31),缺血性卒中(HR 1.13; 0.91-1.42),出血性卒中(HR 1.53; 0.91-2.59)。急性重度加重的COPD患者发生卒中风险可增加6.66 (2.42-18.20)倍。

结论:这项研究显示COPD患者缺血性卒中和出血性卒中的风险增高,并且抽烟是两者共同的危险因子。

原文出处:

Portegies ML, Lahousse L, Joos GF,et al. Chronic Obstructive Pulmonary Disease and the Risk of Stroke: the Rotterdam Study. Am J Respir Crit Care Med. 2015,Sep 28.


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    2016-01-07 sundyli

    流行病学研究,值得收藏!!

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  2. [GetPortalCommentsPageByObjectIdResponse(id=52749, encodeId=aff052e49a3, content=流行病学研究,值得收藏!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Thu Jan 07 16:59:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281194, encodeId=ded5128119487, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385549, encodeId=be7f13855499f, content=<a href='/topic/show?id=83865610462' target=_blank style='color:#2F92EE;'>#抽烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56104, encryptionId=83865610462, topicName=抽烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606673, encodeId=fabb16066e31f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41746, encodeId=a32341e4699, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b911658392, createdName=梦想天空, createdTime=Wed Oct 28 10:13:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
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    2015-10-28 gujh
  4. [GetPortalCommentsPageByObjectIdResponse(id=52749, encodeId=aff052e49a3, content=流行病学研究,值得收藏!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=192, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1ee1610161, createdName=sundyli, createdTime=Thu Jan 07 16:59:00 CST 2016, time=2016-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1281194, encodeId=ded5128119487, content=<a href='/topic/show?id=455f36085f0' target=_blank style='color:#2F92EE;'>#卒中风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=36085, encryptionId=455f36085f0, topicName=卒中风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f1167, createdName=wmr111, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1385549, encodeId=be7f13855499f, content=<a href='/topic/show?id=83865610462' target=_blank style='color:#2F92EE;'>#抽烟#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56104, encryptionId=83865610462, topicName=抽烟)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1606673, encodeId=fabb16066e31f, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Wed Oct 28 11:26:00 CST 2015, time=2015-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=41746, encodeId=a32341e4699, content=赞, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8b911658392, createdName=梦想天空, createdTime=Wed Oct 28 10:13:00 CST 2015, time=2015-10-28, status=1, ipAttribution=)]
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    2015-10-28 梦想天空

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