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Lancet Oncol:贝伐单抗可提高铂化疗敏感的复发性卵巢癌患者生存率

2017-04-24 zhangfan MedSci原创

在标准化疗方案中添加贝伐单抗可以提高铂类药物敏感的复发性卵巢癌患者的中位生存期

以为铂基础的化疗是初始治疗后6个月的卵巢癌复发患者的标准治疗手段。近日研究人员检测了贝伐单抗对这类复发患者的作用。

在这项名为GOG-0213的多中心、开放随机III期临床研究中,招募的患者为18岁以上的可测量或可评估复发性卵巢上皮癌、原发性腹膜癌或输卵管癌患者,这些患者在之前的治疗中对含铂化疗完全应答并且在上一轮化疗结束后至少6个月无进展。招募的患者随机(1:1)接受三周一个周期的紫杉醇+卡铂化疗或接受紫杉醇+卡铂+贝伐单抗(每三周一次直至疾病进展或发生不可接受的毒性)。研究的主要终点是总生存率。

研究于2007年至2011年间进行,共674名患者参与,中位随访期为49.6个月,该时间点共415人死亡(化疗组214人,贝伐单抗组201人);中位生存期方面,42.2个月vs 37.3个月,贝伐单抗组vs化疗组。贝伐单抗组中96%的患者表现出三级以上的不良事件而化疗组为86%,常见的不良事件发生率,高血压(12% vs 1%,贝伐单抗组vs化疗组)、疲劳(8% vs 2%)以及蛋白尿(8% vs 0%),化疗组发生了2起治疗导致死亡而贝伐单抗组发生了9起。

研究认为,在标准化疗方案中添加贝伐单抗可以提高铂类药物敏感的复发性卵巢癌患者的中位生存期。

原文出处:


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    2018-03-18 howi
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    2017-11-16 minlingfeng
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  5. 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  6. 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  7. 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    2017-04-26 doctorJiangchao

    抗血管治疗确实可以用于卵巢癌

    0

  8. 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