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Blood：SGN-CD19B，以PBD为基础的抗CD19抗体结合物，对恶性B细胞肿瘤的治疗潜能。

2017-09-14 qinqiyun MedSci原创

SGN-CD19B恶性B细胞肿瘤抗CD19抗体
关注

复发性/难治性B细胞恶性肿瘤（如非霍奇金淋巴瘤 B-NHL、急性淋巴细胞白血病 B-ALL）患者预后较差。即使现在临床已经应用新的靶向治疗，但很多患者仍不能获得完全或持久缓解，提示我们应进一步改善现有的治疗方案。

中心点：

SGN-CD19B在体外具有广谱抗恶性B细胞系活性，包括双敲和三敲的淋巴瘤细胞系。

SGN-CD19B在B-NHL和B-ALL的预临床模型中表现出独特性的抗肿瘤特性。

摘要：

复发性/难治性B细胞恶性肿瘤（如非霍奇金淋巴瘤 B-NHL、急性淋巴细胞白血病 B-ALL）患者预后较差。即使现在临床已经应用新的靶向治疗，但很多患者仍不能获得完全或持久缓解，提示我们应进一步改善现有的治疗方案。

现研究人员对SGN-CD19B——以吡咯苯二氮平(PBD)为基础的抗CD19抗体结合物（ADC）——用于治疗B细胞恶性肿瘤的效果进行探究。与其他类型的ADCs相比，SGN-CD19B可提高治疗效果。表达CD19的肿瘤细胞迅速吸收SGN-CD19B，并释放PBD药物诱导DNA损伤，导致细胞周期（G2-M）阻滞而死亡。

SGN-CD19B对广谱恶性B细胞系均具有抗性，其可诱导移植恶性B细胞的小鼠模型获得持久缓解。

SGN-CD19B单剂量300mcg/kg即可诱导持久缓解；且联合利妥昔单抗时，100mcg/kg即可发挥作用。上述剂量明显低于其他ADC有效负荷所需要的药物剂量。

在猕猴模型中，SGN-CD19B可有效消除外周血和淋巴组织中的CD20+ B淋巴细胞，表明SGN-CD19B在药效学上具有良好的耐受性。

总而言之，临床预实验表明SGN-CD19B是一种高效的ADC。作用机制独特、广谱效价以及与利妥昔单抗结合的潜能，均提示SGN-CD19B或许可开辟一种新的恶性B细胞肿瘤的治疗方案。I期临床试验正在进行，探究SGN-CD19B对于复发性/难治性B-NHL的治疗潜能。

原始出处：

Maureen C. Ryan，et al.Therapeutic potential of SGN-CD19B， a PBD-based anti-CD19 drug conjugate， for treatment of B-cell malignancies.Blood.September 13，2017.https：//doi.org/10.1182/blood-2017-04-779389

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    2017-09-18 大爰

    学习了谢谢分享!!

    0

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    2017-09-16 xiaoyeshuang

    #B细胞#

    0

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    2017-09-16 dingxiaobo

    #CD19#

    0

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    2017-09-15 执着追梦

    学习.谢谢分享

    0

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    2017-09-15 tanxingdoctor

    学习啦!谢谢分享!

    0

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    2017-09-15 yfjms

    学习了

    0

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    2017-09-15 yfjms

    学习了

    0

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    2017-09-14 luominglian113

    学习了.谢谢分享

    0

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    2017-09-14 131****2916

    不错的文章值得学习

    0

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