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JAHA:腹主动脉瘤生长和破裂的生物标志物研究

2018-07-01 MedSci MedSci原创

腹主动脉瘤(AAA)如果不治疗的话会一直生长甚至破裂,有许多生物标志物被发现,但没有一个普遍公认的AAA标志物。本研究的目的旨在寻找新的可以预测AAA生长和破裂的生物标志物。本次荟萃分析的研究筛选、数据提取和质控分析由2名独立的研究者进行,最终共纳入了82例临床研究,其中研究循坏标志物的有40个,生物力学标志物的有27个,遗传标志物的有7个,复合标志物的有8个。与动脉瘤扩张风险增加有关的因素有AA

腹主动脉瘤(AAA)如果不治疗的话会一直生长甚至破裂,有许多生物标志物被发现,但没有一个普遍公认的AAA标志物。本研究的目的旨在寻找新的可以预测AAA生长和破裂的生物标志物。

本次荟萃分析的研究筛选、数据提取和质控分析由2名独立的研究者进行,最终共纳入了82例临床研究,其中研究循坏标志物的有40个,生物力学标志物的有27个,遗传标志物的有7个,复合标志物的有8个。与动脉瘤扩张风险增加有关的因素有AAA直径(n=1938;低偏倚风险)、衣原体肺炎(n=311;中偏倚风险)、S-弹性蛋白肽(n=205;中偏倚风险)、氟代脱氧葡萄糖摄取(n=104;中偏倚风险)和腔内血栓大小(n=758;中偏倚风险)。与动脉瘤破裂有关的因素有峰值壁压力(n=579;中偏倚风险)和AAA直径(n=354;中偏倚风险)。

本研究找到了5个预测腹主动脉瘤生长的因素和2个预测腹主动脉瘤破裂的因素。

原始出处:

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    2018-07-03 zhaohui6731
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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f82367669, createdName=衣觉, createdTime=Sun Jul 01 18:21:38 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328510, encodeId=5d763285104a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 01 17:14:41 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328504, encodeId=d1f132850412, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 01 17:03:23 CST 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  5. 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  6. 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  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f82367669, createdName=衣觉, createdTime=Sun Jul 01 18:21:38 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328510, encodeId=5d763285104a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 01 17:14:41 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328504, encodeId=d1f132850412, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 01 17:03:23 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-02 1201e5c5m39暂无昵称

    学习了

    0

  8. 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encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560752, encodeId=ba151560e52ac, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566761, encodeId=80881566e611c, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328678, encodeId=eaed3286e8f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Mon Jul 02 08:08:24 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328513, encodeId=831432851311, content=好!好, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f82367669, createdName=衣觉, createdTime=Sun Jul 01 18:21:38 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328510, encodeId=5d763285104a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 01 17:14:41 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328504, encodeId=d1f132850412, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 01 17:03:23 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 衣觉

    好!好

    0

  9. 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createdName=zhaohui6731, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1415334, encodeId=d55214153345f, content=<a href='/topic/show?id=04812314540' target=_blank style='color:#2F92EE;'>#主动脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=111, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23145, encryptionId=04812314540, topicName=主动脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=77603112682, createdName=circumcision, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1429038, encodeId=3e481429038b4, content=<a href='/topic/show?id=ee192321560' target=_blank style='color:#2F92EE;'>#主动脉瘤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=87, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23215, encryptionId=ee192321560, topicName=主动脉瘤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=95e34160730, createdName=fengting4, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560752, encodeId=ba151560e52ac, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566761, encodeId=80881566e611c, content=<a href='/topic/show?id=3c746936567' target=_blank style='color:#2F92EE;'>#生物标志#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69365, encryptionId=3c746936567, topicName=生物标志)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=63db15173977, createdName=zhu_jun9842, createdTime=Tue Jul 03 07:40:00 CST 2018, time=2018-07-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328678, encodeId=eaed3286e8f1, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=140, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2ac82155377, createdName=1201e5c5m39暂无昵称, createdTime=Mon Jul 02 08:08:24 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328513, encodeId=831432851311, content=好!好, beContent=null, objectType=article, channel=null, level=null, likeNumber=1, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f82367669, createdName=衣觉, createdTime=Sun Jul 01 18:21:38 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328510, encodeId=5d763285104a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 01 17:14:41 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328504, encodeId=d1f132850412, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 01 17:03:23 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 smartxiuxiu

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1841257, encodeId=2584184125eec, content=<a href='/topic/show?id=18bf61953d3' target=_blank style='color:#2F92EE;'>#标志物#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61953, encryptionId=18bf61953d3, topicName=标志物)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=6ab940, createdName=hukaixun, createdTime=Sun Sep 16 03:40:00 CST 2018, time=2018-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267859, encodeId=4098126e859ac, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=74, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d2f82367669, createdName=衣觉, createdTime=Sun Jul 01 18:21:38 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328510, encodeId=5d763285104a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Sun Jul 01 17:14:41 CST 2018, time=2018-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328504, encodeId=d1f132850412, content=好文章.学习了., beContent=null, objectType=article, channel=null, level=null, likeNumber=129, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=60791943465, createdName=1e0f8808m18(暂无匿称), createdTime=Sun Jul 01 17:03:23 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 1e0f8808m18(暂无匿称)

    好文章.学习了.

    0

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