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J Thromb Haemost:整体和腹部肥胖与静脉血栓栓塞有关

2020-11-15 MedSci原创 MedSci原创

WC可能是将肥胖与VTE联系起来的首选指标。如果人群保持健康的BMI和WC,可以预防大部分的VTE病例。

腹部肥胖已被证实是检测血管风险优于整体肥胖的有效指标。近日,血栓和凝血疾病权威杂志Journal of Thrombosis and Haemostasis上发表了一篇研究文章,研究人员进行了一项研究,以比较整体肥胖和腹部肥胖对VTE的影响,并计算肥胖对于VTE的人群可归因分数。

体重指数(BMI)和腰围(WC)分别代表整体肥胖和腹部肥胖。在队列研究中,研究人员纳入了1997年进行人体测量的74317名瑞典成年人,其中截至2017年底诊断出4332名VTE患者。研究人员进行了孟德尔随机研究,调查了BMI、WC和针对BMI进行校正的WC与VTE的因果关系,研究人员使用了FinnGen和UK Biobank研究的数据。计算整体和腹部肥胖的VTE人群归因分数。

在队列研究中,BMI和WC与VTE存在剂量反应关系。调整WC后,BMI和VTE之间的关联大大减弱。在BMI正常的个体中,WC显著增加的参与者VTE风险比WC正常的参与者高53%(HR为1.53; 95%CI为1.28-1.81)。在MR分析中证实了针对BMI调整后的WC与VTE关联之间的因果关系。估计的由于BMI和WC增加引起的人群归因风险分别为12.4%(8.4%-16.5%)和23.7%(18.1%-29.4%)。

由此可见,WC可能是将肥胖与VTE联系起来的首选指标。如果人群保持健康的BMI和WC,可以预防大部分的VTE病例。

原始出处:

Shuai Yuan.et al.Overall and abdominal obesity in relation to venous thromboembolism.Journal of Thrombosis and Haemostasis.2020.https://doi.org/10.1111/jth.15168

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    2020-12-09 fusion
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    2021-02-26 changfy
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    2021-05-25 xue8602
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    2021-01-01 ms6000001502154832

    有用

    0

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    2020-11-17 ms8000001754662727

    学习了

    0

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  7. [GetPortalCommentsPageByObjectIdResponse(id=1698164, encodeId=658a16981647b, content=<a href='/topic/show?id=f2399910109' target=_blank style='color:#2F92EE;'>#静脉#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99101, encryptionId=f2399910109, topicName=静脉)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0bc129907796, createdName=fusion, createdTime=Wed Dec 09 17:36:29 CST 2020, time=2020-12-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2008489, encodeId=94442008489e8, content=<a href='/topic/show?id=1066844469' target=_blank style='color:#2F92EE;'>#HAE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8444, encryptionId=1066844469, topicName=HAE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=32d177, createdName=changfy, createdTime=Fri Feb 26 16:36:29 CST 2021, time=2021-02-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1955515, encodeId=10af1955515ef, content=<a href='/topic/show?id=0aeb991e44c' target=_blank style='color:#2F92EE;'>#静脉血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=99174, encryptionId=0aeb991e44c, topicName=静脉血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d139492, createdName=xue8602, createdTime=Tue May 25 16:36:29 CST 2021, time=2021-05-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=912915, encodeId=3596912915e2, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=96c35432713, createdName=ms6000001502154832, createdTime=Fri Jan 01 19:01:28 CST 2021, time=2021-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899887, encodeId=856589988ec6, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=110, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ac555424952, createdName=ms8000001754662727, createdTime=Tue Nov 17 15:57:27 CST 2020, time=2020-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1969157, encodeId=ed22196915ee6, content=<a href='/topic/show?id=9cf885694f5' target=_blank style='color:#2F92EE;'>#腹部肥胖#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=51, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85694, encryptionId=9cf885694f5, topicName=腹部肥胖)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3883266, createdName=yykkxiaodou, createdTime=Wed Feb 17 09:36:29 CST 2021, time=2021-02-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899562, encodeId=81fe8995621d, content=一句话,不要吃胖,胖,不仅不好看,对身体也不好。, beContent=null, objectType=article, channel=null, level=null, likeNumber=113, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20211019/df01a4bfb64246379ddfef3370d04115/e1274c8eb5e440918f56f83bcfea9031.jpg, createdBy=3a345397082, createdName=Jessica, createdTime=Mon Nov 16 10:29:47 CST 2020, time=2020-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899327, encodeId=f48989932e63, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d4675435031, createdName=ms8000000564442083, createdTime=Sun Nov 15 15:19:12 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899309, encodeId=57738993091a, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bbc11488193, createdName=thm112988, createdTime=Sun Nov 15 13:28:29 CST 2020, time=2020-11-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=899301, encodeId=950289930176, content=腹部肥胖已被证实是检测心血管风险优于整体肥胖的有效指标。, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4gCIdSaEkahCNuUWZv4iaKmqvUKHyKnBiarBM9RStQKBeV5Lh6GYYFiamdV5KlSfbLvmAgZTLtq81XA/0, createdBy=13511650672, createdName=言西早, createdTime=Sun Nov 15 12:55:04 CST 2020, time=2020-11-15, status=1, ipAttribution=)]
    2020-11-16 Jessica

    一句话,不要吃胖,胖,不仅不好看,对身体也不好。

    0

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    2020-11-15 ms8000000564442083

    有用

    0

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    2020-11-15 thm112988

    0

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    2020-11-15 言西早

    腹部肥胖已被证实是检测心血管风险优于整体肥胖的有效指标。

    0

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