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Sci Rep:胰腺癌细胞分泌的外泌体诱导C2C12肌管细胞胰岛素抵抗的机制

2017-08-05 MedSci MedSci原创

前瞻性流行病学研究均表明,胰腺癌相关的新发糖尿病(PC-DM)是胰腺癌(PC)早期诊断的一个潜在的表现。尽管已有许多研究,但是这种现象背后的机制仍然模糊不清。在这项研究中,研究人员探究了来源于小鼠胰腺癌和小鼠骨骼肌细胞的导管上皮细胞的两种外泌体的影响。结果表明,PC来源的外泌体能够轻易进入C2C12肌管,引发脂质和葡萄糖摄取抑制。此外,PC来源的外泌体还可抑制胰岛素和PI3K/Akt信号通路,由此

前瞻性流行病学研究均表明,胰腺癌相关的新发糖尿病(PC-DM)是胰腺癌(PC)早期诊断的一个潜在的表现。尽管已有许多研究,但是这种现象背后的机制仍然模糊不清。在这项研究中,研究人员探究了来源于小鼠胰腺癌和小鼠骨骼肌细胞的导管上皮细胞的两种外泌体的影响。

结果表明,PC来源的外泌体能够轻易进入C2C12肌管,引发脂质和葡萄糖摄取抑制。此外,PC来源的外泌体还可抑制胰岛素和PI3K/Akt信号通路,由此胰岛素诱导FoxO1核排斥以及GLUT4转运受损。芯片和KEGG数据库分析表明,外泌体miRNAs或在此过程中起着关键的作用,且体外研究证实该假设。

总而言会,这些研究结果证实,骨骼肌细胞的胰岛素抵抗(IR)是由PC来源的外泌体通过胰岛素和PI3K/Akt/FoxO1信号通路所控制的,外泌体miRNAs或可促进这种现象的发生。这些新发现为全面理解癌症理论铺平了道路:“代谢重组”和“代谢串扰”。

原始出处:


Lantian Wang, Bo Zhang, et al., Exosomes derived from pancreatic cancer cells induce insulin resistance in C2C12 myotube cells through the PI3K/Akt/FoxO1 pathway. Sci Rep. 2017; 7: 5384. Published online 2017 Jul 14. doi: 10.1038/s41598-017-05541-4.


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    2017-11-28 gwc392
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    2018-01-03 baoya
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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 yxch36
  5. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-07 luominglian113

    学习了,谢谢分享

    0

  6. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-06 龙胆草

    学习谢谢分享

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-06 忠诚向上

    好好学习一下

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1780494, encodeId=4de21e80494da, content=<a href='/topic/show?id=9e12390472' target=_blank style='color:#2F92EE;'>#C2C12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3904, encryptionId=9e12390472, topicName=C2C12)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Fri Dec 29 00:13:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682339, encodeId=da2216823395b, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue Nov 28 19:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749796, encodeId=50b01e4979649, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Jan 03 10:13:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252317, encodeId=5e84125231ea7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Aug 07 14:13:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230897, encodeId=0f8a23089e1b, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Aug 07 00:05:47 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230605, encodeId=4c3f23060597, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Aug 06 07:44:23 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230575, encodeId=31a72305e541, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 06 07:12:27 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230532, encodeId=27d0230532bf, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Aug 06 05:25:19 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230516, encodeId=0e7623051634, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 06 00:56:32 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230486, encodeId=3469230486da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-06 189****1577

    值得推荐一下

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1780494, encodeId=4de21e80494da, content=<a href='/topic/show?id=9e12390472' target=_blank style='color:#2F92EE;'>#C2C12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3904, encryptionId=9e12390472, topicName=C2C12)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Fri Dec 29 00:13:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682339, encodeId=da2216823395b, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=0da227938338, createdName=gwc392, createdTime=Tue Nov 28 19:13:00 CST 2017, time=2017-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1749796, encodeId=50b01e4979649, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Jan 03 10:13:00 CST 2018, time=2018-01-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252317, encodeId=5e84125231ea7, content=<a href='/topic/show?id=3efee1519b2' target=_blank style='color:#2F92EE;'>#癌细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=61, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Aug 07 14:13:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230897, encodeId=0f8a23089e1b, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Aug 07 00:05:47 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230605, encodeId=4c3f23060597, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Aug 06 07:44:23 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230575, encodeId=31a72305e541, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 06 07:12:27 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230532, encodeId=27d0230532bf, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Aug 06 05:25:19 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230516, encodeId=0e7623051634, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 06 00:56:32 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230486, encodeId=3469230486da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-06 刘煜

    学习了谢谢分享

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1780494, encodeId=4de21e80494da, content=<a href='/topic/show?id=9e12390472' target=_blank style='color:#2F92EE;'>#C2C12#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3904, encryptionId=9e12390472, topicName=C2C12)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=838d2500169, createdName=12498cb5m13暂无昵称, createdTime=Fri Dec 29 00:13:00 CST 2017, time=2017-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1682339, encodeId=da2216823395b, content=<a href='/topic/show?id=d4d031e8074' target=_blank style='color:#2F92EE;'>#分泌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31780, encryptionId=d4d031e8074, topicName=分泌)], attachment=null, authenticateStatus=null, createdAvatar=null, 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topicList=[TopicDto(id=71519, encryptionId=3efee1519b2, topicName=癌细胞)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4cea26, createdName=yxch36, createdTime=Mon Aug 07 14:13:00 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230897, encodeId=0f8a23089e1b, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=82, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=550d2008262, createdName=luominglian113, createdTime=Mon Aug 07 00:05:47 CST 2017, time=2017-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230605, encodeId=4c3f23060597, content=学习谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=89, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4Nd44v3xHnnictn9UpctwtH62EPQ59TMdI9lnqHMgQ16nH7GmGCfpzicsHgjibYVk6vwSpXrC86gMibRkoaIzf5HwSz7/0, createdBy=78cc1691107, createdName=龙胆草, createdTime=Sun Aug 06 07:44:23 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230575, encodeId=31a72305e541, content=好好学习一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=85, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Sun Aug 06 07:12:27 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230532, encodeId=27d0230532bf, content=值得推荐一下, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/ajNVdqHZLLBWOEtiahpXHGVdbFId5PLgK775YNA1ria3lM9KsJT6iczgIhov5sobd1Nr0raUBP58GkUDzvfDic9RCg/0, createdBy=0d021989245, createdName=189****1577, createdTime=Sun Aug 06 05:25:19 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230516, encodeId=0e7623051634, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Sun Aug 06 00:56:32 CST 2017, time=2017-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=230486, encodeId=3469230486da, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/07/21/b08f46ccefbf795993994115d0854e54.jpg, createdBy=16d21717631, createdName=吴晶晶, createdTime=Sat Aug 05 23:39:30 CST 2017, time=2017-08-05, status=1, ipAttribution=)]
    2017-08-05 吴晶晶

    学习了

    0

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